My depression on gear is generally related to overtraining. Test, for example, elevates my moods when I'm working out within reason. But some days the gear makes me feel too much like superman, and when I consequently increase my workouts by too much, I crash. I'm 46, but can't help feeling like I'm twenty years younger when cycling. The CNS response to overtraining just kills me. I have to keep reminding myself that I'm just not capable ot 90 min. workouts anymore. Sometimess it takes me days to mentally recover from a single workout in which I took it too far.