Please Scroll Down to See Forums Below 
THEEGAME2544
New member
Bump for Mods thoughts on this theory?
Why Rotating Clen w/ ECA Might Not Be As Effective As We Think
- Thread starter mrflexdiesel
- Start date
that's just great!! just wonderful!! i wanted to drop a good 10lbs before going to vegas next month so i decided to buy some clen.... i am a female btw and my male friends happen to love it. anyway, i started taking 1 pill a day and went up a pill till i reached 4 and continued for two weeks. then i started taking trim spa w/ephedrine (3 a day) and i was going to go back to clen when the two weeks are up but after reading this article, i am so confused. should i try something else? i've been working out like a maniac and am not seeing crazy results. i've cut out a lot of carbs. should i try hydroxycut, xenadrine, or take more trim spa? my two weeks of dumb trims spa are over on monday so i have no idea what the hell to do -- as you can see!!
supertech69
New member
ckat - I'd continue on as planned. I know that's what I'm going to do untill something is proven otherwise. Personally, I like xenadrine, it's getting hard to get though (the rfa-1 that is). I am on my 5th day of Clen.
I like alternating between Clen/NYC and would recommend this combo instead. The yo-hcl is supposed to help to refresh the receptors and NYC just gives a good break. Also Clen/ECA can be really hard on the prostate, didn't notice that with Clen/NYC. Also I have read that taking Yo hcl along w/Clen will actually allow you to take Clen for longer periods of time i.e. 5-6 weeks without break. I have tried it and noticed no slowdown in fatburning effects... maybe even a slight boost but it was just too taxing on the CNS... started having anxeity problems.
The reason you only run clen for two weeks at a time and many alternate with e/c/a is that Clen seems to work incredibly for periods of about 2-3 weeks, but then, the fat burning effects just stops.
Unlike ephedrine, clen is a "specific" beta 2 agonist, fitting almost perfectly into the receptor site. It stimulates the receptors so well, the body will burn fat very fast. However, being that our bodie's are masters of homeostasis, the body will quickly downregulate the receptors and desensitize them to clen.
Another problem is that clen will slow the rate of T4 to T3 conversion...not good. So, in order for clen to work for a longer amount of time, you must find a way to keep T3 levels optimal.
T3 increases the number of beta receptors on fat and muscle cells, which in turn increases the effect of clen.
This is what leads to the ever popular clen/T3 stack.
Ephedrine has been shown to increase levels of T3 after several weeks of use. It also does not downregulate the beta receptor site like clen does.
So you can now see why people use for 2 weeks on then 2 weeks off if not using T3, although clen/T3 is hard to beat...but then T3 is a whole different subject.
Wrongun!
Unlike ephedrine, clen is a "specific" beta 2 agonist, fitting almost perfectly into the receptor site. It stimulates the receptors so well, the body will burn fat very fast. However, being that our bodie's are masters of homeostasis, the body will quickly downregulate the receptors and desensitize them to clen.
Another problem is that clen will slow the rate of T4 to T3 conversion...not good. So, in order for clen to work for a longer amount of time, you must find a way to keep T3 levels optimal.
T3 increases the number of beta receptors on fat and muscle cells, which in turn increases the effect of clen.
This is what leads to the ever popular clen/T3 stack.
Ephedrine has been shown to increase levels of T3 after several weeks of use. It also does not downregulate the beta receptor site like clen does.
So you can now see why people use for 2 weeks on then 2 weeks off if not using T3, although clen/T3 is hard to beat...but then T3 is a whole different subject.
Wrongun!
macrophage69alpha
New member
the above article shows that the author has little understanding of receptor "down regulation" (there are several types inlcuding cytosolic withdrawal and impact on receptor "refresh" as well as #)
the addition of a new agonist agent tends to "upregulate" receptors (though upregulation and down regulation are artificial constructs that do not wholey represent the actual impact of interaction)
one must also account for secondary receptor (various.. not just b2) system impacts (a2 interaction in particular with ephedrine)..
the addition of a new agonist agent tends to "upregulate" receptors (though upregulation and down regulation are artificial constructs that do not wholey represent the actual impact of interaction)
one must also account for secondary receptor (various.. not just b2) system impacts (a2 interaction in particular with ephedrine)..
macrophage69alpha
New member
just a note- in simple laymens terms... (emphasis on "men")
new agonist are like new women- your "receptors" are much more eager to interact with them
this is why with most drugs (though not all) the first exposure is the strongest.. with lay offs in between often restoring (at least some) of the effects
this does not apply as strictly to some secondary impact drugs (ssri's etc.)
new agonist are like new women- your "receptors" are much more eager to interact with them
this is why with most drugs (though not all) the first exposure is the strongest.. with lay offs in between often restoring (at least some) of the effects
this does not apply as strictly to some secondary impact drugs (ssri's etc.)
mrflexdiesel
New member
Thanks for all of the input guys. It is greatly appreciated. Macro, I think you're a genius!!!
Little Rage
New member
props to macro. and we wonder why they are mods 
karma your way.
karma your way.
