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Ok so why do steroids loose their effectiveness after each cycle and why do some people just keep getting good results cycle after cycle?
Well I think I might have an answer, I believe it is down to the receptor affinity for each steroid, and the amount of Aromatase and 5-alpha reductase enzyme in your body.
All steroids have different Affinities for the Androgen receptor e.g. Anavar binds strongly and that is why it is made in 2.5 mg tablets. Whereas Anadrol 50 does not bind very well and thus it has 50 mg per tablet.
One very important point is that once an Androgen receptor is occupied by a strongly binding Androgen like DHT, weaker binding Androgens like Anadrol can not displace the DHT molecule.
This is where genetics comes in.
Example:
You have 2 bodybuilders who decide to start taking Testosterone in equal amounts. Bodybuilder (A) has little or no 5 alpha reductase enzyme in his body, while Bodybuilder (B) has a high amounts of the enzyme.
In the beginning both bodybuilders should respond equally well to the Testosterone as their Receptors are fresh. However as time goes by and more and more of the Testosterone in Bodybuilder (B) is converted to DHT his muscle receptors which have a testosterone molecule bound to them are displaced by the stronger binding DHT.
Once a DHT or even an Estrogen molecule binds to a receptor, Testosterone is blocked and cannot trigger a response.
Essentially this would mean that any further Testosterone you inject will have little or no effect, as your receptors are blocked by DHT or Estrogen.
This would mean that the effects of steroids on Bodybuilder (B) would diminish more rapidly than for Bodybuilder (A).
So this would also mean that Genetics or the amount of 5-alpha reductase and aromatase enzyme you were born with will determine how well and how long steroids will work for you.
Still not convinced?
Well research has shown that obese men given Testosterone decreased body fat by 9.1%, while a second group who where given DHT INCREASED their body fat by 7.1% and the third group who where given a placebo experienced no change.
This would mean that bodybuilder (B) will eventually start to get fatter and fatter as more and more of the Testosterone he injects is converted to DHT.
And there is more
Well I think I might have an answer, I believe it is down to the receptor affinity for each steroid, and the amount of Aromatase and 5-alpha reductase enzyme in your body.
All steroids have different Affinities for the Androgen receptor e.g. Anavar binds strongly and that is why it is made in 2.5 mg tablets. Whereas Anadrol 50 does not bind very well and thus it has 50 mg per tablet.
One very important point is that once an Androgen receptor is occupied by a strongly binding Androgen like DHT, weaker binding Androgens like Anadrol can not displace the DHT molecule.
This is where genetics comes in.
Example:
You have 2 bodybuilders who decide to start taking Testosterone in equal amounts. Bodybuilder (A) has little or no 5 alpha reductase enzyme in his body, while Bodybuilder (B) has a high amounts of the enzyme.
In the beginning both bodybuilders should respond equally well to the Testosterone as their Receptors are fresh. However as time goes by and more and more of the Testosterone in Bodybuilder (B) is converted to DHT his muscle receptors which have a testosterone molecule bound to them are displaced by the stronger binding DHT.
Once a DHT or even an Estrogen molecule binds to a receptor, Testosterone is blocked and cannot trigger a response.
Essentially this would mean that any further Testosterone you inject will have little or no effect, as your receptors are blocked by DHT or Estrogen.
This would mean that the effects of steroids on Bodybuilder (B) would diminish more rapidly than for Bodybuilder (A).
So this would also mean that Genetics or the amount of 5-alpha reductase and aromatase enzyme you were born with will determine how well and how long steroids will work for you.
Still not convinced?
Well research has shown that obese men given Testosterone decreased body fat by 9.1%, while a second group who where given DHT INCREASED their body fat by 7.1% and the third group who where given a placebo experienced no change.
This would mean that bodybuilder (B) will eventually start to get fatter and fatter as more and more of the Testosterone he injects is converted to DHT.
And there is more
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