Who here has stayed on anti-estrogens year round even while off?

[mike1107]

The reason is two-fold. 1st is becuase it blocks extra test to be converted into estrogen thus leaving it as test or being converted to dht. Second is because you lost bodyfat and the less bodyfat the less aromatization since this process mostly takes place in fat cells.

I knew the first reason,didn't know the second ... I love anti oestrogen

 

[jdubs952]

FYI: estrogen is responsible for male sex behavior. I dont remember whether it was copulatory or courtship...or both

 

[DrJMW]

I like Aromasin during a cycle and Nolvadex for post-cycle.




Effect of letrozole on the lipid profile in postmenopausal women with breast cancer.
Eur J Cancer 2001 Aug;37(12):1510-3 (ISSN: 0959-8049)
Elisaf MS; Bairaktari ET; Nicolaides C; Kakaidi B; Tzallas CS; Katsaraki A; Pavlidis NA
Department of Internal Medicine, Medical School, University of Ioannina, GR 451 10 Ioannina, Greece. [email protected].
Hormonal therapy plays a central role in the overall treatment of breast cancer. Aromatase inhibitors can inhibit the aromatase enzyme system resulting in a reduction of oestrogens. Letrozole is a non-steroidal aromatase inhibitor that effectively blocks aromatase activity without interfering with adrenal steroid biosynthesis. The drug can significantly reduce the levels of plasma oestrogens, which remain suppressed throughout the treatment. Data are scarce concerning the influence of these drugs on serum lipid levels. In the present study, we evaluated the effects of letrozole on the serum lipid profile in postmenopausal women with breast cancer. A total of 20 patients with breast cancer were treated with letrozole, 2.5 mg once daily. After an overnight fast, serum lipid parameters (total cholesterol, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1, B and E and lipoprotein (a)) were measured before treatment and at 8 and 16 weeks afterwards. A significant increase in total cholesterol (P=0.05), LDL cholesterol (P<0.01) and apolipoprotein B levels (P=0.05) in the serum, as well as in the atherogenic risk ratios total cholesterol/HDL cholesterol (P<0.005) and LDL cholesterol/HDL cholesterol (P<0.005) was noticed after letrozole treatment. We conclude that letrozole administration in postmenopausal women with breast cancer has an unfavourable effect on the serum lipid profile.

Aromasin does not affect the lipid profile.

 

[wartime100]

I don't know if it is wise to never go off anti estrogens. They could have long term side effects. I don't think there is anything wrong with using them for long periods of time but not all year round.

 

[Lumberg]

I don't think you can definitively say Letrozole (or other anti-es) hurt your blood lipid profile. One alternative theory:

not having any estrogen circulating in your body makes you feel like shit. Thus you tend to eat more "comfort foods" (foods high in fat and sugar) to elevate your mood. Boom, higher blood lipids.

So doctors will have to do a study where diet is strictly controlled both before and during anti-e therapy to rule out that factor.

JC

 

[SOLID]

I'd love to see the proof of this.

then go here

 

[BigAndy69]

What about your bones? Osteoperosis anyone?

 

[naturally anabolic]

then go here

that A) only talks about endometrial cancer as being a problem, last time i checked i didnt have a uterus, so i will pass.

for the rest of my life i am to be on a regiment of 3 months Tamoxifen 20mg/day and then switch to 3months Arimidex 1mg/day