Shouldn't take it period as there are far better options which are far more conducive to our needs than outdated tamoxefin. It leads to a significant decrease in IGF-1 and I think has been implicated to cause/exacerbate some cancerous growth. Of which kind I'm not sure and if that's true I'm not sure, nut none the less it's enough cause for concern and with alternate options nolvadex just doesn't make sense.