Physiological factors that suppress GH secretion are hypothyroidism, obesity, hyperglycemia and excess glucocorticoids.
There are three hypothalamic modifiers of GH:
1. Growth Hormone Releasing Hormone (GHRH) also known as Somatocrinin
2. GHRELIN
3. Somatostatin
Pancreatic somatostatin inhibits the release of both insulin and glucagon, while in the central nervous system (CNS) somatostatin inhibits the actions of several hypothalamic hormones, including growth hormone releasing hormone (GHRH). For this reason somatostatin is also known as growth hormone release inhibiting hormone. Whereas GHRH induces release of growth hormone stored in secretory vesicles by depolarization of the somatotrope, somatostatin inhibits GH release by hyperpolarizing the somatotrope, rendering it unresponsive to GHRH.
Jenetic