Please Scroll Down to See Forums Below
Usnic Acid
- Thread starter eando
- Start date
LiquidPhire
New member
Sorry I haven't but its compared to dnp - dinitrophenol - , another thing I don't wanna try anytime soon..
"Effects on the liver
In the above study comparing UA to DNP, UA was about 50 times more potent an uncoupler. This single in vitro study, despite the absence of any in vivo studies examining UA’s effect upon thermogenesis or body weight, fostered a number of dietary supplements incorporating pure UA or its sodium salt. Most notable was a product called LipoKinetix, which was associated with severe chemical hepatitis (elevated liver enzymes in blood, jaundice, vomiting) in seven previously healthy men and women.5 The duration of use in this cohort ranged from 10 days to 12 weeks. LipoKinetix was comprised of phenylpropanolamine, sodium usnate, a thyroid hormone precursor, diiodothyronine, yohimbine and caffeine. Thus, attributing the acute hepatotoxicity to UA alone is unfounded. Notably, after each of the subjects ceased using this product, their liver enzyme profiles normalised.
Recent research has subjected mouse liver cells to UA in vitro and found both oxidative stress and toxicity, which could be prevented by the pre-addition of a fat-soluble antioxidant like alpha-tocopheryl succinate (vitamin E).6 Interestingly, DNP also showed similar oxidative and toxic effects, which were in fact not mitigated by vitamin E.
Another study found high-dose (200mg/kg) injections of UA for five days had no significant effect on blood liver enzymes but a demonstrable effect on liver cell size and shape, indicative of a toxic effect.7
One area of promising use for UA in hepatology is with an inherited metabolic defect called tyrosinemia I, an often-fatal fibrotic liver disease marked by disordered collagen metabolism. Recent investigations suggest that UA, which inhibits the plant form of the deranged enzyme characteristic of this disease, may indeed be a candidate for clinical therapy.8,9"
http://www.functionalingredientsmag.com/fimag/articleDisplay.asp?strArticleId=468&strSite=FFNSite
Also this from BodyBuilding.com
Usnic Acid: Good, Bad, Or…
Ugly. Really ugly, according to researchers. Usnic Acid is a substance currently sold and promoted as a weight loss product.
Usnic Acid (sodium usniate) was a substance promoted by the late bodybuilding guru Dan Duchaine, and it was originally thought to inhibit tumor growth, as well as inhibiting the growth of other deadly diseases. Currently, United States law allows for the sale of usnic acid as a "dietary supplement" because it is found naturally in tree moss.
The only problem is that it is very unsafe. In fact, like DNP, the dose required to burn optimal fat is the dose that will kill you! This is one product that you want to steer clear of. Buyers beware.
SOURCE: Vet Hum Toxicol 28:574-575, 1986.
"Effects on the liver
In the above study comparing UA to DNP, UA was about 50 times more potent an uncoupler. This single in vitro study, despite the absence of any in vivo studies examining UA’s effect upon thermogenesis or body weight, fostered a number of dietary supplements incorporating pure UA or its sodium salt. Most notable was a product called LipoKinetix, which was associated with severe chemical hepatitis (elevated liver enzymes in blood, jaundice, vomiting) in seven previously healthy men and women.5 The duration of use in this cohort ranged from 10 days to 12 weeks. LipoKinetix was comprised of phenylpropanolamine, sodium usnate, a thyroid hormone precursor, diiodothyronine, yohimbine and caffeine. Thus, attributing the acute hepatotoxicity to UA alone is unfounded. Notably, after each of the subjects ceased using this product, their liver enzyme profiles normalised.
Recent research has subjected mouse liver cells to UA in vitro and found both oxidative stress and toxicity, which could be prevented by the pre-addition of a fat-soluble antioxidant like alpha-tocopheryl succinate (vitamin E).6 Interestingly, DNP also showed similar oxidative and toxic effects, which were in fact not mitigated by vitamin E.
Another study found high-dose (200mg/kg) injections of UA for five days had no significant effect on blood liver enzymes but a demonstrable effect on liver cell size and shape, indicative of a toxic effect.7
One area of promising use for UA in hepatology is with an inherited metabolic defect called tyrosinemia I, an often-fatal fibrotic liver disease marked by disordered collagen metabolism. Recent investigations suggest that UA, which inhibits the plant form of the deranged enzyme characteristic of this disease, may indeed be a candidate for clinical therapy.8,9"
http://www.functionalingredientsmag.com/fimag/articleDisplay.asp?strArticleId=468&strSite=FFNSite
Also this from BodyBuilding.com
Usnic Acid: Good, Bad, Or…
Ugly. Really ugly, according to researchers. Usnic Acid is a substance currently sold and promoted as a weight loss product.
Usnic Acid (sodium usniate) was a substance promoted by the late bodybuilding guru Dan Duchaine, and it was originally thought to inhibit tumor growth, as well as inhibiting the growth of other deadly diseases. Currently, United States law allows for the sale of usnic acid as a "dietary supplement" because it is found naturally in tree moss.
The only problem is that it is very unsafe. In fact, like DNP, the dose required to burn optimal fat is the dose that will kill you! This is one product that you want to steer clear of. Buyers beware.
SOURCE: Vet Hum Toxicol 28:574-575, 1986.
