I have never tried pgf2a, but from what I gather it is used for 2 bodybuilding purposes: 1) Cause localized muscle growth and 2) Caused localized destruction of fat cells. DMSO is going to carry the pgf2a through the skin and put it into general circulation which will probably give you the side effect like nausea, abdominal cramping, and projectile diarrhea without the benefits of localized administration. It seems like an IM shot is the way to go with this stuff.