Tren= new muscle cells???

[XCYTER]

In a post "Keeping Gear Results" someone mentioned that Tren creates new muscle cells. I thought only HGH had that ability.
Anyone with some info on this??

 

[TNH]

Its possible through IGF-1......tren is supposed to have quite an effect on IGF-1 levels, which could explain the good gains, hair growth, and possible gyno that some people have a problem with.

 

[Punschkrapfen]

talking about IGF-1, there was an interesting article in the July 2002 issue of MD. They cited - amongst others - this study:

Endocrinology 1989 May;124(5):2110-7 Related Articles, Books, LinkOut


Trenbolone alters the responsiveness of skeletal muscle satellite cells to fibroblast growth factor and insulin-like growth factor I.

Thompson SH, Boxhorn LK, Kong WY, Allen RE.

Department of Animal Sciences, University of Arizona, Tucson 85721.

The potential role of satellite cells in mediating the effect of trenbolone [17 beta-hydroxyestra-4,9-11-trien-3-one (TBOH)] on skeletal muscle hypertrophy was examined. Young female Sprague-Dawley rats received TBOH injections daily for 2 weeks; growth, body composition, and the composition of selected muscles were assessed. Treated rats grew more rapidly and deposited less body lipid and more protein. The semimembranosus muscle from treated rats was larger and had approximately 60% more DNA per muscle than muscles from control rats. The addition of trenbolone directly to the medium of cultured satellite cells did not stimulate cell proliferation, nor did it augment the stimulatory response of these cells to fibroblast growth factor (FGF) or insulin-like growth factor I (IGF-I). In contrast, satellite cells cultured from TBOH-treated rats exhibited greater proliferative responses to FGF and IGF-I than satellite cells from control rats. In addition, serum from TBOH-treated rats stimulated greater cell proliferation in satellite cell cultures than serum from control rats. These experiments suggest that one possible mechanism responsible for the ability of TBOH to stimulate skeletal muscle hypertrophy may be through enhanced proliferation and differentiation of satellite cells as a result of the increased sensitivity of these cells to IGF-I and FGF.


"The addition, or fusion, of satellite cells may explain why gains made on trenbolone are usually well maintained off-cycle" (MD 7-2002, p197).

 

[me2dammit]

yeah

I asked around and looked inot this and from what I can tell tren does this the best. Thats why I wonder if staying on TREN for prolonged periods alters the muscle in our body in such a way genetic potential can be altered a greater deal than any other steriod.

 

[XCYTER]

Moderators??????

 

[Briweve]

This brings up a good point that I have been thinking about for a long time. I know that people say only A -bombs have been linked to cancer. But isn't cancer the reckless replicating of new cells. Now thinking that Tren creates 60% more DNA per Muscle, doesn't that kinda mean there is alot per DNA replicating, which would greatly increase your chances for cancer?

 

[XCYTER]

BUMP......

Moderators.....seems we need some help!

 

[Magnússon]

Bumpin' very interesting

 

[mytmo]

Bump for some good info

 

[Mike P.T.]

Well all steroids for the most part increase igf-1 anyway to some degree. Some more some less. For example, steroids that aromatize into estrogen such as testosterone have shown to increase igf-1 levels. Wether this is just from the actual test itself or because of the increased estrogen from the aromatization process I do not know. I do know though that estrogen helps in the synthesis of igf and also in it's increased sensitivity in the organs. That is why they say that anti-estrogens lower igf-1 production because of the interference with estrogen whether it's from eliminating it from reaching it's desired receptor or from stopping it's production entirely. C-17 alkylated steroids have also been shown to have a great increase in igf-1 due to the liver having to work harder at "cleaving" away at the steroid thus stimulating igf-1 production. IGF-1 as we know is produced in the liver. GH obviously having the most impact because it converts directly into igf-1 via the liver.

As for the cancer aspect of it all steroids can have an affect on that but so can so many things in our environment. Taken in excess and especially if having a genetic predisposition for it and/or taking the steroids that affect it the most obviously can increase it's chances. But by how much?? How many times do you actually hear on the news that someone died from cancer solely because of the use of steroids. Ehhhhhh hardly ever, and even in those cases that you do it was definately hyped. My 2 cents.