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napsgear
genezapharmateuticals
domestic-supply
puritysourcelabs
Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

Transdermal Yohimbine

superturkey

Banned
I guess when we pick the ingredients we must know why. This is because most people like to know why they are rubbing this stuff on and what it’s going to do… Knowing that we must start with knowing if Yom-hcl is hydrophilic or hydrophobic. Water loving or water hating…

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Hydrophilic
Water loving. Compounds of this type are attracted to water. Normally they are either charged or have polar side groups that attract water to them.
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Knowing thins aspect of Yom-hcl we will chose ingredients that are water based or “skin wetting” to get the Yom-hcl through the SC into the fatty deposits. One thing we have to avoid mostly is getting the Yom-hcl into the blood stream. Yes Yom-hcl will do well in the e blood stream for fat loss but it will not be localized, as this is what we are trying to achieve with this product.
Since the Yom-hcl is water loving and water passes through the SC VERY easy because the SC has allot of water contained in it, if we can get the Yom-hcl into a water based gel the Yom-hcl will get to where we want to deliver it.
One other thing why we choose ingredients that we do is also because of price. We want the average Joe with some love handles or some hard to get off flab from their guts to be able to make this stuff…. Like me J

Ingredient #1 Aloe Vera Gel(99%) 50%
The Aloe-Vera gel consists of 96 % water. But the secret lies in its high portion of natural nutrients and vital substances. The nutritious ingredients of Aloe Vera can be divided into the following groups:
Vitamins
It is rich in most vitamins like Vitamin D, A (the antioxidant beta-carotene), C and E and even traces of B12, one of the very few plant sources of this vitamin.

Enzymes
Several of these biochemical catalysts aid digestion by breaking down fat and sugars when taken orally. The Aloe Vera contains Lipases and proteases which break down foods and aid digestion.
It also contains bradykinase, which helps to reduce excessive inflammation and pain when applied to the skin.

Minerals
Aloe Vera contains more than 20 minerals, like Calcium, Sodium, Potassium, Manganese, Magnesium, Copper, Zinc, Chromium and the anti-oxidant Selenium.
Even though minerals and trace elements are only needed in very small quantities, they are essential for the proper functioning of various enzyme systems in different metabolic pathways.

Salicylic acid
It is anti-inflammatory and anti-bacterial properties.

Sugars
Known as mucopolysaccharides, they enhance the immune system and help to detoxify. In topical preparations, the sugars are also the main moisturisers.

Anthraquinones
There are twelve of these Phenolic compounds which are found exclusive in the plant sap. In small quantities, they aid absorption from the gastro-intestinal tract and have anti-microbial and pain killing effects. The important ones are the painkillers Aloin and Emodin. They also are anti-bacterial and anti-viral.

Lignin
It gives Aloe Vera a singular penetrative effect so the other ingredients are absorbed into the skin.

Saponins
They have cleansing, and antiseptic properties, acting powerfully against bacteria, viruses, fungi and yeasts.

Fatty Acids
Cholesterol, Campesterol, ß.Sisosterol and Jupeol. These four plant steroids found in Aloe Vera are important anti-inflammatory agents.

Amino acids
The body needs 22 amino acids - our Aloe Vera gel provides 20 of these. More importantly, it provides 7 out of the 8 essential amino acids which the body itself cannot synthesise.
Seeing all these thing isn the aloe gel and knowing it is 96% water makes it a very good ingredient to get the Yom-hcl through the SC…Also the GEL of the gel make this product have a good consistency thin enough to spray through a spray bottle or pumped through a pump bottle.

Ingredient #2 Water 25%
Since Yom-hcl is hydrophilic it likes water and water absorbs VERY good through the SC.

Ingredient #3 Propylene Glycol 10%
PG this stuff is oily. What it does is keeps the moisture from leaving the skin. The more moisture the easier it is for the Yom-hcl to penetrate...

Ingredient #4 Menthol(75% solution) 15%

We have gone through (above) to make the 75% solution. So we won’t go over that again. But here is why we use menthol in the solution.

Menthol derivatives as potential skin penetration enhancers Studies showed that the permeation enhancing effect of l-menthol is significantly high with short lag time (12). The promoting activity of the ethyl ether derivative of Menthol is the greatest of all menthol derivatives. Studies showed that it is the most promising compound which has the greatest action and relatively low skin irritancy (13,14). A study has been made to elucidate the mechanism of skin permeation enhancement and it was concluded that the increase in skin flux, to eight times the base line, could be attributed to the effect of menthol on the skin barrier properties (15). The mechanism of permeation enhancement of menthol has been studied by some other investigators and they concluded that it could involve its distribution preferentially into the intercellular spaces of stratum corneum and the possible reversible disruption of the intercellular lipid domain. They suggested the use of menthol as effective penetration enhancer (16).
As you can see menthol is a good penetrator. Making it like this also is very cheap. Which is good. Also the ISO used to make the menthol solution is good for dissolving the Yom-hcl into the solution.



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