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The truth about guaifenesin and ephedrine
- Thread starter skacorica
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macrophage69alpha
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skacorica said:
shhh... your posting misinformation... guaifenesin is a muscle relaxant, anaesthetic and anti-adrenergic agent.
glyceryl guaiacolate ether (GGE)- AKA- guaifenesin
GGE is regarded as a spinally-acting muscle relaxant and is used to provide maintenance conditions as part of several total intravenous anaesthetic techniques. It acts as a muscle relaxant and a vehicle for other drugs. Its mechanism of action is poorly understood; it acts on polysynaptic reflex arcs in the spinal cord, reticular formation and sub-cortical areas of the brain in a mephenesin-like manner. Its prominent feature is an ability to depress internuncial neurone transmission in the spinal cord without impairing breathing. in North America, GGE is considered to have CNS depressant effects beyond muscle relaxation; elsewhere, it is not used as a sole anaesthetic but always given with other CNS depressant drugs
macrophage69alpha
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skacorica said:
btw- there is a lot of debate on whether its actually effective as an expectorant.
skacorica
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macrophage69alpha said:
Yes and no...for the purpose of these boards: it is not a muscle relaxant. Guaifenesin carbamate is used as a muscle relaxant because it is LONGER LASTING, however in the dosages with ephedrine even IT would have negligible effect. If you look it up, the dosages for muscle relaxant are not less than 1600mg of the carbamate.
I don't know as much about biochemistry as you but I remember that propanediol's (the form in Vaspro) are rapidly metabolized, thus there is no stacking effect between the dosages...but Ill modify the original to fit
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macrophage69alpha
New member
skacorica said:Yes and no...for the purpose of these boards: it is not a muscle relaxant. Guaifenesin carbamate is used as a muscle relaxant because it is LONGER LASTING, however in the dosages with ephedrine even IT would have negligible effect. If you look it up, the dosages for muscle relaxant are not less than 1600mg of the carbamate.
I don't know as much about biochemistry as you but I remember that propanediol's (the form in Vaspro) are rapidly metabolized, thus there is no stacking effect between the dosages...but Ill modify the original to fit
dosage used of guaifenesin carbamate are 500mg, the equivalent of 400mg of guaifenesin. (a 1500mg dosage over the day- in three doses). A longer half life in this case is due to a slower release. 200mg is more than sufficient to have muscle relaxant effects. Probably not as strong as 500mg of guaifenesin carbamate- however still muscle relaxant effects.
half life of guaifenesin is 1hr (since most people take 45min to just prior to workout this is an issue)
some other interesting studies
J Altern Complement Med. 2004 Dec;10(6):967-9. Related Articles, Links
Ephedrine- and guaifenesin-induced nephrolithiasis.
Bennett S, Hoffman N, Monga M.
Department of Urologic Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
OBJECTIVES: Ephedrine and guaifenesin are herbal supplements that have experienced increased use over the past decade. Ephedrine has been used as a stimulant and weight-loss product, guaifenesin as an expectorant and cough suppressant; both are found in combination in many antitussives and expectorants. This paper reviews the reported cases of ephedrine- and guaifenesin-induced nephrolithiasis, as well as the diagnostic techniques and treatments that have been successfully used for these stones. DESIGN: A systematic review of the literature pertaining to nephrolithiasis and the compounds ephedrine and guaifenesin was conducted. RESULTS: Ephedrine and guaifenesin use results in over 35% of urinary stones that are related to pharmaceutical metabolites, and collectively are present in 0.1% of all urinary stones. These calculi are radiolucent, requiring the use of computerized tomography (CT scan) for diagnosis. Alkalinization therapy offers an alternative to surgical intervention and may have a role in prevention of recurrence. CONCLUSIONS: Ephedrine and guaifenesin have been shown to cause nephrolithiasis in cases of abuse when taken individually or in combination. It is important for the clinician to be aware of the potential for these compounds to cause nephrolithiasis.
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