i have been on hrt for nearly three years at 100 mg per week.i have experimented with 100,150,and 200mg/week and found recently that my levels are more stable at 60 to 80 mg every 3.5 days which i do on sun am and wed pm.so far i prefer the twice weekly route.blood levels peak at 2 days after injection for both cyp and enan and stay at peak till 3.5 days then fall gradually back to baseline levels at 10 days this route allows a more linear response to blood levels than once /week
Many people on HRT need an AI when on 100mg per week. 0.25mg Arimidex every other day is a common starting point. Most doctors don't like prescribing over 100mg per week. Although, some people need much higher dosages in order to feel "normal". I personally think it's better to treat the patient rather than the numbers.