Tamoxifen & Shooting Blanks (Study)

[geoffgarst]

Interesting Study on Tamoxifen - thought I would pass along:


Title: Effect of chronic administration of Tamoxifen on fertility in male bonnet monkeys (Macaca radiata).

Researchers: Rao AJ, Ramachandra SG, Ramesh V, Krishnamurthy HN, Jayaraman S, Gopalakrishnan K, Juneja HS

Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.

Source: Andrologia 1998 May-Jun;30(3):129-32

Summary: Administration of Tamoxifen via the Alzet pump at a rate of 50 micrograms hr-1 for 90 days in the adult male bonnet monkeys Macaca radiata had no effect on the serum testosterone concentration determined at 10 AM and 10 PM as well as total sperm count determined at 15-day intervals over a period of 260 days. However, a significant reduction in sperm motility was observed beyond 90 days up until the 225th day. Breeding studies conducted from day 90 to 260 revealed that these males were infertile.

Discussion: Tamoxifen, or Nolvadex, is classified as an antiestrogen. I’m sure most of you are already familiar with this drug. It works as an antiestrogen by competitively binding to estrogen receptors. Although it has high affinity for estrogen receptors it has little if any estrogenic effects in most tissues. It is used by bodybuilders to prevent or treat gynecomastia and water retention. The interesting thing about this study was the fact that Tamoxifen, an antiestrogen, made the male monkeys infertile. This is in agreement with another recent study looking at the effects of an aromatase inhibitor (Steroids 1998 Jul-Aug;63(7-8):414-20) on fertility also in male monkeys. Both of these studies point to an important role of estrogen in male fertility. Tamoxifen, unlike the aromatase inhibitor which caused a 2-10 fold increase in serum testosterone levels, showed no effect on serum testosterone. The effect on spermatogenesis was clearly due to estrogen. Their sperm count was fairly normal, however, the sperm couldn’t swim to save their own lives. The take home message is that if you want to start a family between shows, stay away from Nolvadex and Proviron. On the other hand, these two compounds may be potential male birth control remedies. I guess the glass is either half full or half empty depending on how you look at it.

PS: KARMA is always welcome here.

 

[dzulboy]

um isn't nolvadex just a really really week estrogen so if you kept using it over long periods of time it only makes sense that, that would happen

 

[dzulboy]

oh and i would have given ya karma but apparently i don't spread it around enough to give it to youagain sorry geoff

 

[ROID WARRIOR]

What was the aromatase inhibitor which caused a 2-10 fold increase in serum testosterone levels?

RW

 

[Nelson Montana]

Well, of course.

But, at the end of the study it concudes Nolva and Proviron. I think they mean Nolva and clomid since they're so similar. Proviron has been shown to inccease sperm count.

I know sperm count and semen aren't necessarily related, but i found when I used either Noa or clomid, that when I ejaculated, I felt "empty." Strangest fucking feeling in the world and not a pleasant one.

New slogan. "Clomid blows -- and so does its little cousin Nolvadex."

 

[dinoallbino]

I dunno Nelson,
When I unload on clomid, its quite a noticeable difference than without (meaningI fill up the box and spill out the side!) And I get that empty feeling too, but I like it, feels like you just purged all that stressful goo out for a few hours until you refill. Clomid spunks are the kind where your balls smack your taint 3 different times before you can get it all out! And in the middle of all this you're grunting like a silverback gorilla getting his first handjob. I like clomid, and have never experienced any of the sides always associated with it to a degree that I've found noticeable. Although I've never used Prov.

 

[Nelson Montana]

dino: Are you sure you don't write for the porno paperbacks they sell in the subway newstands? : )

You're one of the lucky ones that has a positive reaction to clomid. Not everyone does.

 

[dinoallbino]

Ha! No, but does that job pay well?
And yes I guess I am lucky with the clomid, but even still, I've decided this time to go with HCG/Nolva just because of all the bad press clomid seems to get, I'm willing to try a diff combo post cycle with perhaps better results. Maybe you could steer me in the right direction with the HCG/nolva. How long do I wait to shoot up the HCG after my last Sust250 shot? And whats a good dosage and duration. Plus, what would you suggest as far as recovery supplements after I'm off the HCG and Nolva? Thanks in advance for any info.