Take Zinc with your IGF-1 to ampliy it's effects.

[Anthony Roberts]

Here's where this information was originally posted:

http://www.anthony-roberts.com/blog/?p=51

This is a repost from my Blog Today, from my website:

Taking Zinc with your IGF will produce much better results. Zinc can do two things which we want, when we take it with our IGF.

1. Zinc will decrease IGF-1 binding proteins ability to bind to (and deactivate) IGF-1.

2. Zinc will increase IGF-1 receptor sensitivity to IGF-1.

Here's the abstract:

J Endocrinol. 2004 Feb;180(2):227-46
Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors.
McCusker RH,
Novakofski J.
The Department of Animal Sciences, Laboratory for Developmental Endocrinology, The University of Illinois, Urbana, Illinois 61801, USA. [email protected]
Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning the effects of Zn(2+) on soluble IGFBPs and the type 2 IGF receptor (IGF-2R). In the current work, we demonstrate that Zn(2+) affects the affinity of IGFBP-5 secreted by myoblasts but not IGFBP-4. Zn(2+), at physiological levels, depressed binding of both IGF-I and IGF-II to IGFBP-5, affecting (125)I-IGF-I more than (125)I-IGF-II. Both (125)I-IGF-I and (125)I-IGF-II bound to high and low affinity sites on IGFBP-5. Zn(2+) converted the high affinity binding sites of IGFBP-5 into low affinity binding sites. An IGF-I analog, (125)I-R(3)-IGF-I, did not bind to the soluble murine IGFBP-5. Zn(2+) also decreased the affinity of the IGF-2R on L6 myoblasts. In contrast, Zn(2+) increased IGF-I, IGF-II and R(3)-IGF-I binding to the IGF-1R by increasing ligand binding affinity on both P(2)A(2a)-LISN and L6 myoblasts. Soluble IGFBP-5 and IGFBP-4 depressed the binding of (125)I-IGF-I and (125)I-IGF-II to the IGF-1R, but did not affect binding of (125)I-R(3)-IGF-I. By depressing the association of the IGFs with soluble IGFBP-5, Zn(2+) partitioned (125)I-IGF-I and (125)I-IGF-II from soluble IGFBP-5 onto cell surface IGF-1Rs. This effect is not seen when soluble L6-derived IGFBP-4 is present in extracellular fluids. We introduce a novel mechanism by which the trace micronutrient Zn(2+) may alter IGF distribution, i.e. Zn(2+) acts to increase IGF-1R binding at the expense of IGF binding to soluble IGFBP-5 and the IGF-2R.

 

[ALIN]

Great, valuable information.

 

[Ianhockey91]

How much and when in relation too.

 

[galaxy]

"Interestingly, one of those sources replied with information that they have the full line of British Dragon orals….yet their name is not recognized by the BD database as an approved remailer."

I was just reading your "sources and spams" blog, anyway just an FYI some sources do carry BD, it just so happens as part of the deal they cant be listed on the approved list.. why? well, just the inside inner workings. .....You can alway email BD and just ask them too.

Another interesting note is that some sources spam competitors emails to get them shut down. Just more of those nice inner workings.

Anyway, sorry to hijack..........back on topic..................make sure you drink some milk or eat something with your zinc or you will hurl chunks.

 

[krishna]

Do you take it at the same time you take the IGF, or just take it daily as a supplement?

 

[OMEGA]

....

 

[dosteov]

Here's where this information was originally posted:

http://www.anthony-roberts.com/blog/?p=51

This is a repost from my Blog Today, from my website:

Taking Zinc with your IGF will produce much better results. Zinc can do two things which we want, when we take it with our IGF.

1. Zinc will decrease IGF-1 binding proteins ability to bind to (and deactivate) IGF-1.

2. Zinc will increase IGF-1 receptor sensitivity to IGF-1.

Here's the abstract:

J Endocrinol. 2004 Feb;180(2):227-46
Zinc partitions IGFs from soluble IGF binding proteins (IGFBP)-5, but not soluble IGFBP-4, to myoblast IGF type 1 receptors.
McCusker RH,
Novakofski J.
The Department of Animal Sciences, Laboratory for Developmental Endocrinology, The University of Illinois, Urbana, Illinois 61801, USA. [email protected]
Zinc (Zn(2+)), a multifunctional micronutrient, was recently shown to lower the affinity of cell-associated insulin-like growth factor (IGF) binding protein (IGFBP)-3 and IGFBP-5 for both IGF-I and IGF-II, but to increase the affinity of the cell surface type 1 IGF receptor (IGF-1R) for the same two ligands. However, there is a need for data concerning the effects of Zn(2+) on soluble IGFBPs and the type 2 IGF receptor (IGF-2R). In the current work, we demonstrate that Zn(2+) affects the affinity of IGFBP-5 secreted by myoblasts but not IGFBP-4. Zn(2+), at physiological levels, depressed binding of both IGF-I and IGF-II to IGFBP-5, affecting (125)I-IGF-I more than (125)I-IGF-II. Both (125)I-IGF-I and (125)I-IGF-II bound to high and low affinity sites on IGFBP-5. Zn(2+) converted the high affinity binding sites of IGFBP-5 into low affinity binding sites. An IGF-I analog, (125)I-R(3)-IGF-I, did not bind to the soluble murine IGFBP-5. Zn(2+) also decreased the affinity of the IGF-2R on L6 myoblasts. In contrast, Zn(2+) increased IGF-I, IGF-II and R(3)-IGF-I binding to the IGF-1R by increasing ligand binding affinity on both P(2)A(2a)-LISN and L6 myoblasts. Soluble IGFBP-5 and IGFBP-4 depressed the binding of (125)I-IGF-I and (125)I-IGF-II to the IGF-1R, but did not affect binding of (125)I-R(3)-IGF-I. By depressing the association of the IGFs with soluble IGFBP-5, Zn(2+) partitioned (125)I-IGF-I and (125)I-IGF-II from soluble IGFBP-5 onto cell surface IGF-1Rs. This effect is not seen when soluble L6-derived IGFBP-4 is present in extracellular fluids. We introduce a novel mechanism by which the trace micronutrient Zn(2+) may alter IGF distribution, i.e. Zn(2+) acts to increase IGF-1R binding at the expense of IGF binding to soluble IGFBP-5 and the IGF-2R.

So I guess the same applies for HGH since it stimulates the liver to secrete IGF?

How much zinc are we talking about?

 

[Wrongun]

Must admit avid reader of your blogs

I like your style of saying it as you think. Most of what you say i agree some i don't but you put your case well and makes me question all which is beneficial

Similar to Nelson Montanna really (sorry you are both different but i mean both make me think and re-look at logic that has been unquestioned before)

good luck with your books and thanks for your input

Wrongun!

 

[Anthony Roberts]

"Interestingly, one of those sources replied with information that they have the full line of British Dragon orals….yet their name is not recognized by the BD database as an approved remailer."

I was just reading your "sources and spams" blog, anyway just an FYI some sources do carry BD, it just so happens as part of the deal they cant be listed on the approved list.. why? well, just the inside inner workings. .....You can alway email BD and just ask them too.

I know exactly why people might be not listed as BD remailers and still carry BD products. But in the end, when you advertise that you carry the BD line and then you aren't an approved remailer, it looks bad. Personally, I don't trust the source(s) who ended up on that spam e-mail list too highly.

I don't really have to e-mail BD about this, either...I speak with one of their three owners on a daily basis. From what I understand, the sources in question are simply small-time players, who can't move enough product, and make the correct guarentees regarding shipping and such, per month to be considered an official remailer. If you're not an official remailer, I think it's shady to advertise yourself primarily as having BD stuff for sale....it shows that you can't make the guarentees to the actual company who produces those products, but you are willing to make certain assurances to your clients....which aren't backed by the manufacturer in any way, shape, or form.

My advice is to stick with BD remailers who are approved, in every case.

 

[Anthony Roberts]

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