Everybody's different. search up my posts back a long time ago about my BAD T3 experience. and I only went up to 50mcg and that was also just for several days. Did the tapering just by the book too.. experienced pretty bad sides (unbelievable lethargy), almost thought about going with T3 for life, but it went away with good supplementation of tyrosine within 3 weeks. I noticed shit from it.. IMO not worth it.