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drveejay11
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The overall physiological effects of the active thyroid hormones are to:
1) Increases Basal Metabolic Rate
2) Make more glucose available to meet the elevated metabolic demands by increasing glysolysis, gluconeogenesis, and glucose absorption from the intestine
3) Stimulates protein synthesis
4) Increases lipid metabolism and conversion of cholesterol into bile acids and other substances, activation of lipoprotein lipase, and increase sensitivity of adipose tissue to lipolysis by other hormones
5) Stimulate the heart rate, cardiac output, and blood flow
6) Increase neural transmission and neuronal development (in the young)
MORE for the intellectual type......
Action of the Thyroid Hormones: Thyroxine and triiodothyronine, once released into the circulation, act on many different target cells in the body. The overall function of T4 and T3 are similar though much of the biological activity may be the ressult of monodeiodination to 3,5,3'-triiodothyronine prior to interacting with target cells. Under certain conditions (protein starvation, neonatal animals, liver and kidney disease, febrile illness, etc) thyroxine is preferentially monodeiodinated to 3,3',5'-triiodothryonine ("reverse T3"). Since this form of T3 formed by target cells is biologically inactive, monodeiodination to form "reverse T3" provides a mechanism to attenuate the metabolic effects of thyroid hormones.
1) Increases Basal Metabolic Rate
2) Make more glucose available to meet the elevated metabolic demands by increasing glysolysis, gluconeogenesis, and glucose absorption from the intestine
3) Stimulates protein synthesis
4) Increases lipid metabolism and conversion of cholesterol into bile acids and other substances, activation of lipoprotein lipase, and increase sensitivity of adipose tissue to lipolysis by other hormones
5) Stimulate the heart rate, cardiac output, and blood flow
6) Increase neural transmission and neuronal development (in the young)
MORE for the intellectual type......
Action of the Thyroid Hormones: Thyroxine and triiodothyronine, once released into the circulation, act on many different target cells in the body. The overall function of T4 and T3 are similar though much of the biological activity may be the ressult of monodeiodination to 3,5,3'-triiodothyronine prior to interacting with target cells. Under certain conditions (protein starvation, neonatal animals, liver and kidney disease, febrile illness, etc) thyroxine is preferentially monodeiodinated to 3,3',5'-triiodothryonine ("reverse T3"). Since this form of T3 formed by target cells is biologically inactive, monodeiodination to form "reverse T3" provides a mechanism to attenuate the metabolic effects of thyroid hormones.
