52_21_30 said:
I would prefer t4 just because it's "safer". By that I mean you dont need to taper up and down like T3 and can stay on longer. Also, mis-dosings with T4 aren't as dangerous as T3.
There is NO, I repeat NO danger to exogenous T3 usage. It has no permanent affects on the human thyroid, and cardiovascular problems generally only arise if your cardiovascular state has already been compromised vis-a-vis a medical condition. I hate to break it, but this is just an old wives tale. Also, It is wise to taper up and down any drug, be it T4, T3, clen or any of these.
An early study that looked at thyroid function and recovery under the influence of exogenous thyroid hormone was undertaken by Greer (2). He looked at patients who were misdiagnosed as being hypothyroid and put on thyroid hormone replacement for as long as 30 years. When the medication was withdrawn, their thyroids quickly returned to normal.
"In 1951, Greer reported the pattern of recovery of thyroid function after stopping suppressive treatment with thyroid hormone in euthyroid [normal] subjects based on sequential measurements of their thyroidal uptake of radioiodine. He observed that after withdrawal of exogenous thyroid therapy, thyroid function, in terms of radioiodine uptake, returned to normal in most subjects within two weeks. He further observed that thyroid function returned as rapidly in those subjects whose glands had been depressed by several years of thyroid medication as it did in those whose gland had been depressed for only a few days" (3)
The implications to this discovery are quite massive. In direct contradiction to the propaganda of many noted sources of bodybuilding literature, the administration of exegenous T3 will not produce any lasting negative effects on the human thyroid. This hormone can be administered indefinately without negative glandular reprocussions.
These results have been subsequently verified in several studies.(3)(4)
(2)(Greer,M. N Engl J Med 244:385, 1951)
(3)N Engl J Med 1975 Oct 2;293(14):681-4 Recovery of pituitary thyrotropic function after withdrawal of prolonged thyroid-suppression therapy. Vagenakis AG, Braverman LE, Azizi F, Portinay GI, Ingbar SH.
(4) J Clin Endocrinol Metab 1975 Jul;41(1):70-80 Patterns off recovery of the hypothalamic-pituitary-thyroid axis in patients taken of chronic thyroid therapy. Krugman LG, Hershman JM, Chopra IJ, Levine GA, Pekary E, Geffner DL, Chua Teco GN
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