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CrimsonKing
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I found this article while research for my t3 cycle I am about to run.
http://www.cnm-inc.com/wilsyn.pdf
It was very interesting. I've posted some of the article below for the 'link impaired' bros. Basically, it outlines a very good cycle that recommends dosing ever 12 hours, two days up, three days down.
Also gives some great data on common FAQ's like contraindications, drug interactions, common sides, max dosing. Also, I've never heard of Wilson's Syndrome before
Denis Wilson,MD,identified Wilson ’s syndrome as a disease state in 1990. The syndrome is characterized by consistently low body temperature taken by mouth with a mercury thermometer for a full five to six minutes at three,six and nine hours after rising,in combination with the related symptoms described below.
Symptoms
The symptoms of Wilson ’s syndrome are the same as those associated with low thyroid function,including illiness;fatigue;easy weight gain;fluid retention;dry eyes;dry skin;dry hair or hair loss;weak,brittle unhealthy nails;constipation and concentration impairment.Other possible associated symptoms include insomnia,
headaches,irritability,anxiety and panic attacks,depresion,premenstrual syndrome,irregular periods,low sexual desire and low self-esteem.
Patients Most Likely To Be Affected
While the majority (up to 80%)of patients are women,
men can develop he condition as well.It is more common among individuals whose ancestors have sustained repeated famines,such as the Native American,Irish,Welsh and Russian populations. Individuals who have fasted for prolonged periods or severely restricted their caloric intake are at great risk for Wilson ’s syndrome as well.This is especially true if,after these dietary restrictions,the individual regains greater than 10%of his/her initial weight.Many individuals develop the symptoms
(chilliness,fatigue,weight gain)after pregnancy or after a
prolonged period of stress (childbirth,divorce,death of a
loved one,surgery,prolonged job stress)
Diagnosis
A normal serum thyroid-stimulating hormone in combination with oral temperatures averaging consistently below 98.2 °F with he symptoms described above confirms the diagnosis of Wilson ’s syndrome.Temperatures should be taken 15 or more min-
utes away from cold or warm drinks or food,and away from smoking,showering and exercise. Temperatures are not to be taken during menstruation,ovulation,concurrent treatment with pain or fever-lowering medications or periods of illness when low-grade or full fevers may be present.
Causes of Low Body Temperatures
In Wilson ’s syndrome,although circulating blood levels of hyroid-stimulating hormone,thyroxin (T4)and triiodothyronine (T3)or liothyronine are within normal limits,conversion from T4 to T3 in the liver and at the cell-membrane receptor sites (periphery)is impaired.Since T3 is the biologically active form of thyroid hormone, the patient presents with persistent hypothyroid symp-
toms in spite of normal lab values. Additionally,a period
of stress and starvation induces he conversion of T4 into
the biologically inert stereoisomer called reverse T3 .
Reverse T3 is a mirror image of T3 and fits well into T3
cell-membrane receptor sites upside down.Once bound
to these receptors,reverse T3 prevents T3 from binding,
thus preventing thyroid activation at these receptor sites.
Identification of either poor conversion or receptor sites
blocked with inert reverse T3 is just one of the many
ways low temperature and fatigue can evolve into chronic
problems.Adrenal insufficiency (especially abnormally
high or low cortisol with low dehydroepiandrosterone
(DHEA)causes these symptoms as well.If a patient is
adrenal insufficient,giving the patient cyclic T3 could
aggravate his/her adrenal insufficiency.It is safest to first
screen patients with a circadian salivary cortisol and DHEA (test before administering T3 therapy).
Other causes of hermoregulation impairment (low temperatures)include growth-hormone deficiencies;malnutrition (low total caloric intake);hypoglycemia;essential fatty acid deficiencies;and low estrogen,testosterone,progesterone,adrenaline or
neurotensin.
Therefore,a complete endocrine and dietary assessment of each patient is indicated before embarking on T3 therapy as the sole intervention in hermoregulation.
T3 Therapy Administration, Regulation and Monitoring
Wilson emphasizes a dosage schedule that raises T3 doses on a daily basis. However,in my clinical experience,it is most efficient and safest to begin dosing patients withwhat I call a two-day compensating schedule. (In this context,compen-
sating means that the patient reaches and maintains an average temperature of 98.6 °F in wo days.)It raises the dose by 7.5 µg every two days.Each day the proper doseis taken exactly every 12 hours and then raised after two days at each given dosage.
The standard dose cycle begins at 7.5 µg,one every 12 hours,and then increases the dose by 7.5-µg intervals every two days.Our starting dose pack peaks at 37.5-µg capsules.Once this dose is reached,the patient tapers down to 30 µg,then 22.5 µg,then
15 µg,then 7.5 µg,taking each dose once every 12 hours for three days hroughout this weaning-down cycle.This dose pack contains a total of 44 capsules,ten for each dosage (one every 12 hours for the two days going up and the three days going
down)except the four capsules at the 37.5-µg peak dose.
Features of the Two-Day Compensating Schedule
With the dose at 7.5-µg intervals,features of he two-day compensating schedule areas follows:
1.One every 12 hours,two days up and three days down;
2.Gradual dose increases;
3.Less chances of side effects as dose rises;
4.Compensation (reached 98.6 °F)on the second day;
5.Missing of he one-day compensator.
http://www.cnm-inc.com/wilsyn.pdf
It was very interesting. I've posted some of the article below for the 'link impaired' bros. Basically, it outlines a very good cycle that recommends dosing ever 12 hours, two days up, three days down.
Also gives some great data on common FAQ's like contraindications, drug interactions, common sides, max dosing. Also, I've never heard of Wilson's Syndrome before
Denis Wilson,MD,identified Wilson ’s syndrome as a disease state in 1990. The syndrome is characterized by consistently low body temperature taken by mouth with a mercury thermometer for a full five to six minutes at three,six and nine hours after rising,in combination with the related symptoms described below.
Symptoms
The symptoms of Wilson ’s syndrome are the same as those associated with low thyroid function,including illiness;fatigue;easy weight gain;fluid retention;dry eyes;dry skin;dry hair or hair loss;weak,brittle unhealthy nails;constipation and concentration impairment.Other possible associated symptoms include insomnia,
headaches,irritability,anxiety and panic attacks,depresion,premenstrual syndrome,irregular periods,low sexual desire and low self-esteem.
Patients Most Likely To Be Affected
While the majority (up to 80%)of patients are women,
men can develop he condition as well.It is more common among individuals whose ancestors have sustained repeated famines,such as the Native American,Irish,Welsh and Russian populations. Individuals who have fasted for prolonged periods or severely restricted their caloric intake are at great risk for Wilson ’s syndrome as well.This is especially true if,after these dietary restrictions,the individual regains greater than 10%of his/her initial weight.Many individuals develop the symptoms
(chilliness,fatigue,weight gain)after pregnancy or after a
prolonged period of stress (childbirth,divorce,death of a
loved one,surgery,prolonged job stress)
Diagnosis
A normal serum thyroid-stimulating hormone in combination with oral temperatures averaging consistently below 98.2 °F with he symptoms described above confirms the diagnosis of Wilson ’s syndrome.Temperatures should be taken 15 or more min-
utes away from cold or warm drinks or food,and away from smoking,showering and exercise. Temperatures are not to be taken during menstruation,ovulation,concurrent treatment with pain or fever-lowering medications or periods of illness when low-grade or full fevers may be present.
Causes of Low Body Temperatures
In Wilson ’s syndrome,although circulating blood levels of hyroid-stimulating hormone,thyroxin (T4)and triiodothyronine (T3)or liothyronine are within normal limits,conversion from T4 to T3 in the liver and at the cell-membrane receptor sites (periphery)is impaired.Since T3 is the biologically active form of thyroid hormone, the patient presents with persistent hypothyroid symp-
toms in spite of normal lab values. Additionally,a period
of stress and starvation induces he conversion of T4 into
the biologically inert stereoisomer called reverse T3 .
Reverse T3 is a mirror image of T3 and fits well into T3
cell-membrane receptor sites upside down.Once bound
to these receptors,reverse T3 prevents T3 from binding,
thus preventing thyroid activation at these receptor sites.
Identification of either poor conversion or receptor sites
blocked with inert reverse T3 is just one of the many
ways low temperature and fatigue can evolve into chronic
problems.Adrenal insufficiency (especially abnormally
high or low cortisol with low dehydroepiandrosterone
(DHEA)causes these symptoms as well.If a patient is
adrenal insufficient,giving the patient cyclic T3 could
aggravate his/her adrenal insufficiency.It is safest to first
screen patients with a circadian salivary cortisol and DHEA (test before administering T3 therapy).
Other causes of hermoregulation impairment (low temperatures)include growth-hormone deficiencies;malnutrition (low total caloric intake);hypoglycemia;essential fatty acid deficiencies;and low estrogen,testosterone,progesterone,adrenaline or
neurotensin.
Therefore,a complete endocrine and dietary assessment of each patient is indicated before embarking on T3 therapy as the sole intervention in hermoregulation.
T3 Therapy Administration, Regulation and Monitoring
Wilson emphasizes a dosage schedule that raises T3 doses on a daily basis. However,in my clinical experience,it is most efficient and safest to begin dosing patients withwhat I call a two-day compensating schedule. (In this context,compen-
sating means that the patient reaches and maintains an average temperature of 98.6 °F in wo days.)It raises the dose by 7.5 µg every two days.Each day the proper doseis taken exactly every 12 hours and then raised after two days at each given dosage.
The standard dose cycle begins at 7.5 µg,one every 12 hours,and then increases the dose by 7.5-µg intervals every two days.Our starting dose pack peaks at 37.5-µg capsules.Once this dose is reached,the patient tapers down to 30 µg,then 22.5 µg,then
15 µg,then 7.5 µg,taking each dose once every 12 hours for three days hroughout this weaning-down cycle.This dose pack contains a total of 44 capsules,ten for each dosage (one every 12 hours for the two days going up and the three days going
down)except the four capsules at the 37.5-µg peak dose.
Features of the Two-Day Compensating Schedule
With the dose at 7.5-µg intervals,features of he two-day compensating schedule areas follows:
1.One every 12 hours,two days up and three days down;
2.Gradual dose increases;
3.Less chances of side effects as dose rises;
4.Compensation (reached 98.6 °F)on the second day;
5.Missing of he one-day compensator.
