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Taken after a search was performed: W. Llewellyn's musclemonthly:
Not too many steroids have an air of mystique about them quite like trenbolone. It is one of those agents that you will hear talked up aggressively by some guy in the gym, to later find he has not even tried it himself yet. The bodybuilding literature is full of strong, unusual, and often-inaccurate statements about this drug, and consequently an air of misunderstanding has begun to cloud our view of trenbolone. The unusual history of this compound, including prolonged periods of very limited availability and high selling prices, has no doubt played a part in shaping the view of this steroid in the minds of athletes. It seems when anything is out of reach, overly expensive or both, people start looking at it in a different way. I therefore thought it would be a good idea to take a closer look at the physical properties of trenbolone, as well as its current state of availability and use.
Trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one)
Structure
Structurally trenbolone is a derivative of nandrolone, carrying two additional double carbon bonds at positions 9 and 11 (hence the prefix "tren", short for tri-en). The activity of trenbolone differs from that of its parent hormone considerably however. To begin with, trenbolone cannot aromatize to estrogen. The delta-9 group present on its structure occupies a bond necessary for aromatization of the A-Ring to be possible. Unless this group is removed metabolically, which it does not appear to be, estrogen synthesis is impossible in the body. Although nandrolone is a weak substrate for aromatase, estrogen levels can still rise during use. With trenbolone we actually expect a lowering of serum estrogen levels, as it should suppress endogenous testosterone release (the primary substrate for estradiol in men).
Androgenic Activity
Although derived from nandrolone, trenbolone is comparatively far more androgenic than this steroid. In fact it is several times stronger in this regard than our primary androgen testosterone as well (1). The first contributing factor to this of course is that trenbolone is a strong binder of the androgen receptor. This trait is also characteristic of its parent nandrolone, which is several times more active than testosterone in this regard. Androgen binding is in fact further enhanced by the introduction of double bonds in delta-9,11 (2), which makes trenbolone an even more potent agonist of the androgen receptor than nandrolone. Perhaps more significant though is the fact that unlike nandrolone, the strong receptor binding potency of trenbolone is not diminished in androgen sensitive tissues by 5-alpha reductase. Trenbolone does not seem to undergo 5-alpha reduction in humans to any appreciable degree at all, which is evidenced by the fact that the major urinary metabolites of trenbolone all possess the original tri-en structure with an intact delta-4 group (3). So trenbolone retains its original potency as it enters cells in androgen target tissues with high 5AR concentrations, as this enzyme is not affecting it. These factors work together to allow trenbolone to be a potently androgenic steroid, instead of a primarily anabolic one in nature like nandrolone. .
Not too many steroids have an air of mystique about them quite like trenbolone. It is one of those agents that you will hear talked up aggressively by some guy in the gym, to later find he has not even tried it himself yet. The bodybuilding literature is full of strong, unusual, and often-inaccurate statements about this drug, and consequently an air of misunderstanding has begun to cloud our view of trenbolone. The unusual history of this compound, including prolonged periods of very limited availability and high selling prices, has no doubt played a part in shaping the view of this steroid in the minds of athletes. It seems when anything is out of reach, overly expensive or both, people start looking at it in a different way. I therefore thought it would be a good idea to take a closer look at the physical properties of trenbolone, as well as its current state of availability and use.
Trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one)
Structure
Structurally trenbolone is a derivative of nandrolone, carrying two additional double carbon bonds at positions 9 and 11 (hence the prefix "tren", short for tri-en). The activity of trenbolone differs from that of its parent hormone considerably however. To begin with, trenbolone cannot aromatize to estrogen. The delta-9 group present on its structure occupies a bond necessary for aromatization of the A-Ring to be possible. Unless this group is removed metabolically, which it does not appear to be, estrogen synthesis is impossible in the body. Although nandrolone is a weak substrate for aromatase, estrogen levels can still rise during use. With trenbolone we actually expect a lowering of serum estrogen levels, as it should suppress endogenous testosterone release (the primary substrate for estradiol in men).
Androgenic Activity
Although derived from nandrolone, trenbolone is comparatively far more androgenic than this steroid. In fact it is several times stronger in this regard than our primary androgen testosterone as well (1). The first contributing factor to this of course is that trenbolone is a strong binder of the androgen receptor. This trait is also characteristic of its parent nandrolone, which is several times more active than testosterone in this regard. Androgen binding is in fact further enhanced by the introduction of double bonds in delta-9,11 (2), which makes trenbolone an even more potent agonist of the androgen receptor than nandrolone. Perhaps more significant though is the fact that unlike nandrolone, the strong receptor binding potency of trenbolone is not diminished in androgen sensitive tissues by 5-alpha reductase. Trenbolone does not seem to undergo 5-alpha reduction in humans to any appreciable degree at all, which is evidenced by the fact that the major urinary metabolites of trenbolone all possess the original tri-en structure with an intact delta-4 group (3). So trenbolone retains its original potency as it enters cells in androgen target tissues with high 5AR concentrations, as this enzyme is not affecting it. These factors work together to allow trenbolone to be a potently androgenic steroid, instead of a primarily anabolic one in nature like nandrolone. .
