steroid receptors?

[sixfoot2whiteboy]

ive been doing a search on this but is all scientific mumbojumbo i dont really understand...ive been told that if someone doesnt have the right amont of steroid receptors then they will never gain no matter what...what do u guys think about this etc...thanks in advance.

 

[Apexx]

There may be some truth to that, but I've also read that steroids actually increase the number of receptors in the body.

 

[Makavelli]

AAS increase the number of androgen receptors. What those people are actually referring to, whithout know it, is the density and amount of muscle fibers a person has. A person with dense muscle fibers will quicker and larger on smaller amounts of AAS, than a person that doesn't have full muscle bellies.

 

[Tux]

Stupid genetics... why do I have to have crappy genetics? Eh well, at least things like IGF-1 can increase hyperplasia and not just hypertrophy, so eventually I can get more muscle cells than I was supposed to have in addition to just bigger ones. Yay for science.

 

[gymratforlife]

Stupid genetics... why do I have to have crappy genetics? Eh well, at least things like IGF-1 can increase hyperplasia and not just hypertrophy, so eventually I can get more muscle cells than I was supposed to have in addition to just bigger ones. Yay for science.

Gh does this too.

 

[LoneTree]

There may be some truth to that, but I've also read that steroids actually increase the number of receptors in the body.

No, they don't.
Actually, if you take too much roids for too long, there may be down-regulation (decrease) in steroid receptors. This happens with most other receptors, so it is likely that it also happens with roids.
That is why people to have take higher and higher doses to achieve the same result.
I think people vary in how many receptors they have in which muscle group. That probably explains the 'lagging' parts.
99.9% people have normal level of steroid receptors.

 

[shamrock11]

You can't increase the number of receptors. If you have fewer receptors you can still grow, but it will not be as good and as quick as someone with more receptors.

 

[silverbackn]

I don't think androgen receptors down regulate. I've heard the opposite happens, if it didn't 500mg's of AAS a week would give you the same growth as 2G's. If there was a saturation point like that, there would be a definite wall of diminishing returns (obviously specific to the individual). Just a theory.

 

[LoneTree]

I don't think androgen receptors down regulate. I've heard the opposite happens, if it didn't 500mg's of AAS a week would give you the same growth as 2G's. If there was a saturation point like that, there would be a definite wall of diminishing returns (obviously specific to the individual). Just a theory.

You cannot have your own 'theroies'.
There has to be science behind it.

 

[Dieselgoku23]

Yeah I was wondering about receptors, I doing 1g of Test E a week and for next cycle going to do test Prop but want to do less!! but I'm thinking my receptors might be saturated

 

[PolfaJelfa]

"Actually, if you take too much roids for too long, there may be down-regulation (decrease) in steroid receptors"

I respectfully say thats false. Show me some proof. Show me some real people. Ive been taking "protein" for some time....no such thing....also the competitive bbs i know are taking the same doses for yrs on with no de-regulation. Its just a myth. I know from personal experience!

 

[LoneTree]

"Actually, if you take too much roids for too long, there may be down-regulation (decrease) in steroid receptors"

I respectfully say thats false. Show me some proof. Show me some real people. Ive been taking "protein" for some time....no such thing....also the competitive bbs i know are taking the same doses for yrs on with no de-regulation. Its just a myth. I know from personal experience!

Receptor down regulation is not a myth.
Just get any general text on physiology and it would tell you that.
In my previous, first cycle, I only took 200 of Deca per week.
Now in my second cycle, I am using about 750 of 3 roids. My gains are not much better than 1st cycle.
Why would people need to take 1gm or 2 gm to get the required results if there was no receptor down regulation.
One long term user mentioned that he stops getting gains after 10 week.
That all point to receptor down regulation.
There is no other explanation.

 

[PolfaJelfa]

Ya...ok tell that to the 10+ people i know who have not been off for over 5 yrs...... THEY TAKE THE SAME AMMOUNTS OF JUICE EACH WEEK.

The reason you may need more to grow is you hopefully should have more msucle each cycle...etc..thsu require..more juice...just as with food......

Ive personally been on for EXTENDED periods of time over 6 months THERE IS NO SUCH THING....

Post the studies..if you have them bro.. But i dotn realy care...like i told you i know from PERSONALL EXPERIENCE....which is most important.

OF course you need more if your mass increases......just as with eating.....you get biger you need more..SIMPLE........you get smaller you need less. IT HAS BEEN POINTED OUT IN SUCH BOOKS AS ANABOLICS 200_ that this is a MYTH.

 

[PolfaJelfa]

Dont take this the wrong way bro. But you are having your second cycle currently and giving us advice on the subject. Please bro. There are many reasons you need more juice as you progress. First of all in the begining muscle is easy to attain. The farther along you get the harder it becomes. Not becuose of deregulation but just because of how it is. Just as if you were natural...you take off make gains and then it slows....same on juice. Bro i have the experience to know that thsi is a myth...not becouse ive read it somewhere but because i knwo from personall experience. I know people whove been on gear for over 15 yrs....DAY IN DAY OUT......Thats all.

 

[PolfaJelfa]

Why do I or my training partner ( amateur bb goign for pro card) always use the sema ammouts of gear when preparign for show etc. No matter if 1st cycle or 100th.?

Bro of course when i get up to for examnple a bloated 270 lbs and want more gains i need to push the pin more.......but that is because of the excess msucle the body is fighting to keep and earn. When i am light and small....i need less. If you dont believe me...ask the people like Quadsweep Radar, Ulter, Etc. Big bros whove been doign this for many more years than I and they will tell you the same.

 

[LoneTree]

There are literally thousands of types of receptors in the body, and they behave pretty much the same way. Receptor down regulation is an established phenomenon.

Many people on this board refuse to accept any downside to AAS.

There was a vet on the board who said that he stops making gains after 10 weeks.

If you stop using AAS for certain period, the receptors will recover. The period for receptors to recover will depend on how much AAs you used and for how long.

I have an extensive scientific knowledge base to start with. I also de extensive research.
I didn't become interested AAS because someone told me about it. I just stumbled on it doing research on other things.

 

[silverbackn]

You cannot have your own 'theroies'.
There has to be science behind it.

I have a degree and an extensive background in physiology as well as a CSCS. My claims aren't unfounded. I do not think AR's downregulate, I think your body just grows to a certain point with a certain amount of gear, then it takes more at some point.

 

[PolfaJelfa]

OK..so you disagree with William Llenyl...a man who is the founding father of literature about AAS.....Anabolics 200,1,2,3,4,5 Author. You disagree with all the profesionall bbs out there. You are on your 2nd cycle and educating us. Bro, in all respect....this is BS. Listen...what your trying to do is comparable to telling someone who witnessed a murder that nothing took place. I HAVE PERSONAL EXPERIENCE..KNOW OVER 10 PEOPLE WHOVE BEEN ON FOR 10 + YRS AND NO SUCH THING......not only are your claims baselless...but you havent even shown any scientific proof...its not there.....and if some scientist does have a false study its baselles to me too. Why...because all the peopel who have ACTUALL EXPEREINCE includign myself KNOW OTHERWISE. I HAVE BEEN ON FOR MORE THAN 6 months(in the past)....know people like i said who are on practically all their life...NO DAMN DE REGULATION....SIMPLE...
Have you been there done that....? No i didnt think so.
Plus the physics of thsi do not add up.
Show me the results based not on assumptions but on real test subjects.....YOU WILL NOT..they are not there.!

 

[Makavelli]

Fuck! I'm tired of this argument! I've stated this so many times and I never save it. Here it goes: Receptor downregulation does not happen. Think of it like this: Let's say you have 5 AR's. At a natural level of test only 3 are filled, so you'll only grow so big. Now add AAS and all 5 are filled. They grow and there are more receptors. You'll continue growing until all AR's are filled. At that point(around 10-12 weeks into a cycle) the only way to continue to grow is to add more AAS so that all AR's are filled again. Understand? If that was not the case then one one increased the amount of AAS employed nothing would happen. Obviously something does happen. The person grows larger.

 

[LoneTree]

You are missing the point.
This thread was started by someone that if steroid receptors can be increased by AAS.
I said no, that cannot happen.
Read my post again.
I only said 'SHORT TERM DOWN REGULATION THAT MAY RECOVER WHEN YOU STOP AAS.'
I don't know if long term down regulation happens. There are no studies.
Spend more time in reading, and less time on oral diarrhea.

 

[LoneTree]

AAS increase the number of androgen receptors. What those people are actually referring to, whithout know it, is the density and amount of muscle fibers a person has. A person with dense muscle fibers will quicker and larger on smaller amounts of AAS, than a person that doesn't have full muscle bellies.

Receptors are counted 'PER MUSCLE FIBRE'.
That is what is physiologically called up-regulation or down-regulation.
You cannot change definitions sitting in your basement.

 

[Makavelli]

You are missing the point.
This thread was started by someone that if steroid receptors can be increased by AAS.
I said no, that cannot happen.
Read my post again.
I only said 'SHORT TERM DOWN REGULATION THAT MAY RECOVER WHEN YOU STOP AAS.'
I don't know if long term down regulation happens. There are no studies.
Spend more time in reading, and less time on oral diarrhea.

Obviously I'm not the one who needs to do more reading. There have been studies that showed that AAS increased, upregulated, AR's. And no I'm not going to hunt them down and post them for your lazy ass. I don't really care if you believe it or not.

 

[PolfaJelfa]

Lonetree,

Listen...you are missing the point. Makevelli...was not debating..long term de regulation...(that is something to laugh at)....he was explaining to you about de-regulation while on a cycle. IT DOES NOT EXIST. SIMPLE.

Makevelli...Bro, i agree with you 100%.
You and me both know this for two reason .......The 1st is Science....but most importantly it is personal experience..which accounts for a million studys.