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Hey guys, I'm a broke college student and i needed a little extra cash so I was thinking about this study that was tacked up at a bus stop. They emailed me with all the info...... it sounds pretty stupid I dont even know what they're trying to do, but I would have to get about 4 small muscle biopsies in my thigh. Wat do you guys think:
EB (Energy Balance) Study
PURPOSE: To determine the influence of eating different amounts of calories and
different amounts of carbohydrate after exercise on the ability to take up sugar
from the blood and breakdown fat the next day.
ELIGIBLE: Healthy, non-smoking men and women, ages 18-45. Women must be
pre-menopausal and not pregnant. Activity level < 2h/week, no evidence of
hyperlipidemia, not overweight (BMI < 25 kg/m2), weight-stable (+ 5 pounds over
past 6 months), not taking any medications (except women taking birth control
pills), not allergic to eggs or soybeans
SUMMARY: If you are eligible for the study and you decide to participate, you
will be asked to perform four overnight experiments at the University of
Michigan General Clinical Research Center (GCRC). For female participants,
each GCRC visit will be done only during the follicular phase of your menstrual
cycle. For this reason (for women only), only 2 trials can be performed per
month. Thus, the completion of all four trials will occur over at least a 2
month period for female subjects.
On four separate occasions you will be asked to stay in the hospital for an
overnight visit (2 consecutive days and one night). Three of the four trials
involve an exercise session. At least one week must separate trials involving
exercise. Therefore, although your total expected time in this study will be 8
days and 4 nights, it may take 3-8 weeks to complete all three visits Your
participation will be over when you have completed the four overnight stays at
the hospital.
Experiments during each hospital visit:
Day 1
After fasting overnight, you will be admitted to the hospital in the morning.
After you are settled in to your hospital room, a blood sample will be taken
from your arm. On three of your four visits you will be asked to exercise to
expend ~700 calories (~90 min) at a moderate intensity on a treadmill (~45 min)
and a stationary bike (~45 min). During the other hospital visit you will
remain resting quietly during this period. After this 90 min period, you will
be allowed to shower. You will be provided with three meals and one snack
during the day. Your diet will be different during each of your hospital
visits. We will change your diets to control the amount of carbohydrates and
total energy you eat. During three of the trials, you will eat adequate
calories to match your daily needs. During one trial, you will eat ~700 less
calories. You will sleep in your hospital room overnight (small blood samples
will continue every 2 h while you sleep).
Day 2
In the morning, an intravenous catheter will be placed in a vein in your hand
(for blood sampling during the procedures described below) and in a vein in
your arm (for infusions and blood sampling). We will then begin a 1 h infusion
of a saline solution containing a small amount of tracer-labeled fat into the
catheter in your forearm. This tracer is naturally occurring in your body. We
will take some blood samples through the catheter in your hand periodically
throughout this 1 h period. At the end of this 1 h infusion Dr. Horowitz, Dr.
Harber, or Dr. Goldenberg will remove a small muscle sample from your thigh.
This muscle biopsy procedure involves numbing a nickel-sized portion of the
skin of your thigh with a local anesthetic, making a small incision (1/4 inch),
and removing a small piece of muscle (approximately the size of 2-3 grains of
rice). The incision will then be closed with a piece of sterile tape. The
injury resulting from the muscle biopsy is very minor and will not prevent you
from performing your general daily activities. After this procedure, a small
amount of glucose and insulin will be injected through the catheter in your
forearm. Small amounts of blood samples will be taken every few minutes for 3
hours through the catheter in your hand vein. This test, called an
“intravenous glucose tolerance test” (IVGTT), is commonly used to assess
insulin sensitivity in diabetics. At the end of the 3 h IVGTT procedure, you
will be fed a meal and discharged from the hospital. Finally, you will be
contacted 1-3 days after each overnight stay in order for us to follow-up with
you about your biopsy incision for the remote possibility of infection.
Total blood volume sampled and muscle biopsies
During each experiment ~106.5 ml (< 4 oz) of blood will be withdrawn and 1
muscle biopsy will be performed. Therefore, for the four trials you will have
a total of ~426 ml of blood removed and a total of 4 muscle biopsies.
EB (Energy Balance) Study
PURPOSE: To determine the influence of eating different amounts of calories and
different amounts of carbohydrate after exercise on the ability to take up sugar
from the blood and breakdown fat the next day.
ELIGIBLE: Healthy, non-smoking men and women, ages 18-45. Women must be
pre-menopausal and not pregnant. Activity level < 2h/week, no evidence of
hyperlipidemia, not overweight (BMI < 25 kg/m2), weight-stable (+ 5 pounds over
past 6 months), not taking any medications (except women taking birth control
pills), not allergic to eggs or soybeans
SUMMARY: If you are eligible for the study and you decide to participate, you
will be asked to perform four overnight experiments at the University of
Michigan General Clinical Research Center (GCRC). For female participants,
each GCRC visit will be done only during the follicular phase of your menstrual
cycle. For this reason (for women only), only 2 trials can be performed per
month. Thus, the completion of all four trials will occur over at least a 2
month period for female subjects.
On four separate occasions you will be asked to stay in the hospital for an
overnight visit (2 consecutive days and one night). Three of the four trials
involve an exercise session. At least one week must separate trials involving
exercise. Therefore, although your total expected time in this study will be 8
days and 4 nights, it may take 3-8 weeks to complete all three visits Your
participation will be over when you have completed the four overnight stays at
the hospital.
Experiments during each hospital visit:
Day 1
After fasting overnight, you will be admitted to the hospital in the morning.
After you are settled in to your hospital room, a blood sample will be taken
from your arm. On three of your four visits you will be asked to exercise to
expend ~700 calories (~90 min) at a moderate intensity on a treadmill (~45 min)
and a stationary bike (~45 min). During the other hospital visit you will
remain resting quietly during this period. After this 90 min period, you will
be allowed to shower. You will be provided with three meals and one snack
during the day. Your diet will be different during each of your hospital
visits. We will change your diets to control the amount of carbohydrates and
total energy you eat. During three of the trials, you will eat adequate
calories to match your daily needs. During one trial, you will eat ~700 less
calories. You will sleep in your hospital room overnight (small blood samples
will continue every 2 h while you sleep).
Day 2
In the morning, an intravenous catheter will be placed in a vein in your hand
(for blood sampling during the procedures described below) and in a vein in
your arm (for infusions and blood sampling). We will then begin a 1 h infusion
of a saline solution containing a small amount of tracer-labeled fat into the
catheter in your forearm. This tracer is naturally occurring in your body. We
will take some blood samples through the catheter in your hand periodically
throughout this 1 h period. At the end of this 1 h infusion Dr. Horowitz, Dr.
Harber, or Dr. Goldenberg will remove a small muscle sample from your thigh.
This muscle biopsy procedure involves numbing a nickel-sized portion of the
skin of your thigh with a local anesthetic, making a small incision (1/4 inch),
and removing a small piece of muscle (approximately the size of 2-3 grains of
rice). The incision will then be closed with a piece of sterile tape. The
injury resulting from the muscle biopsy is very minor and will not prevent you
from performing your general daily activities. After this procedure, a small
amount of glucose and insulin will be injected through the catheter in your
forearm. Small amounts of blood samples will be taken every few minutes for 3
hours through the catheter in your hand vein. This test, called an
“intravenous glucose tolerance test” (IVGTT), is commonly used to assess
insulin sensitivity in diabetics. At the end of the 3 h IVGTT procedure, you
will be fed a meal and discharged from the hospital. Finally, you will be
contacted 1-3 days after each overnight stay in order for us to follow-up with
you about your biopsy incision for the remote possibility of infection.
Total blood volume sampled and muscle biopsies
During each experiment ~106.5 ml (< 4 oz) of blood will be withdrawn and 1
muscle biopsy will be performed. Therefore, for the four trials you will have
a total of ~426 ml of blood removed and a total of 4 muscle biopsies.
