receptors clean?

[mobro]

How long does it supposedly take before your receptors are completely clean again? do they ever fully recover? if you stay off for say 2 years are they back to where they were originally?

 

[mobro]

bump, tricky question or what

 

[bluetwistedsteel67]

receptor downregulation is a myth - they don't need to be "clean" and they don't get saturated. Otherwise the top BBers wouldn't be running year around.

 

[gjohnson5]

I've been wondering about this myself. I have never read anywhere that AR downregulation actually is an issue.
But there is evidence to suggest that steroids work best in 8-12 week cycles.
Maybe it's not a downregulation issue but a HPTA and plasma homeostatis issue

 

[noclue9415]

bump, someone with some knowledge on this please chime in, as i would also like to know how the receptors work and how long to "clear them"

 

[Nelson Montana]

I've been wondering about this myself. I have never read anywhere that AR downregulation actually is an issue.
But there is evidence to suggest that steroids work best in 8-12 week cycles.
Maybe it's not a downregulation issue but a hpta - hypothalamic-pituitary-testicular axis - - hypothalamic-pituitary-testicular axis - and plasma homeostatis issue

You're on the right track. It's more a matter of homeostasis. Taking any drug will lead to a tolerance but if you stay off long enough, the body normalizes and the drug is once again effective. Alcohol is a good example. Build up a tolerance and you can handle more and more. Even if you go off for a long time, if you start up again, it'll hit you a little harder but it won't be like when you first started drinking.

But remember, steroids aren't really "curing" anything. They're quite unique in that regard. Muscle growth is almost a "side effect" of the drugs purpose. The thing is, once you've put on X amount of muscle, you're less likely to have similar gains. That lessened effect really doesn't have anything to do with "receptor acceptance." It's the body's limited reaction to the effects.

 

[noclue9415]

You're on the right track. It's more a matter of homeostasis. Taking any drug will lead to a tolerance but if you stay off long enough, the body normalizes and the drug is once again effective. Alcohol is a good example. Build up a tolerance and you can handle more and more. Even if you go off for a long time, if you start up again, it'll hit you a little harder but it won't be like when you first started drinking.

But remember, steroids aren't really "curing" anything. They're quite unique in that regard. Muscle growth is almost a "side effect" of the drugs purpose. The thing is, once you've put on X amount of muscle, you're less likely to have similar gains. That lessened effect really doesn't have anything to do with "receptor acceptance." It's the body's limited reaction to the effects.

good post!

 

[flotown]

You're on the right track. It's more a matter of homeostasis. Taking any drug will lead to a tolerance but if you stay off long enough, the body normalizes and the drug is once again effective. Alcohol is a good example. Build up a tolerance and you can handle more and more. Even if you go off for a long time, if you start up again, it'll hit you a little harder but it won't be like when you first started drinking.

But remember, steroids aren't really "curing" anything. They're quite unique in that regard. Muscle growth is almost a "side effect" of the drugs purpose. The thing is, once you've put on X amount of muscle, you're less likely to have similar gains. That lessened effect really doesn't have anything to do with "receptor acceptance." It's the body's limited reaction to the effects.

So eventually as time goes by you put as much muscle as certain amout of anabolic androgenic steroids will produce so you do more and more and so on and so on. So is there a point where you can gain no more muscle? Even if say after 40 years of juicin you are taking maybe 10grams of gear a week. I'm just asking what if?

 

[needsize]

You're on the right track. It's more a matter of homeostasis. Taking any drug will lead to a tolerance but if you stay off long enough, the body normalizes and the drug is once again effective. Alcohol is a good example. Build up a tolerance and you can handle more and more. Even if you go off for a long time, if you start up again, it'll hit you a little harder but it won't be like when you first started drinking.

But remember, steroids aren't really "curing" anything. They're quite unique in that regard. Muscle growth is almost a "side effect" of the drugs purpose. The thing is, once you've put on X amount of muscle, you're less likely to have similar gains. That lessened effect really doesn't have anything to do with "receptor acceptance." It's the body's limited reaction to the effects.

I was going to say basically the same thing. The body is an amazingly adaptive machine, it will quickly adapt to anything you put in it, thats why drug users are always having to use more and more to achieve similar effects. Same with juice, I have found cycles where I pyramid the doses up help with this, but in the end its still the same, the body adapts so you might as well go off or drop your doses right down

 

[LiquidPhire]

So eventually as time goes by you put as much muscle as certain amout of anabolic androgenic steroids will produce so you do more and more and so on and so on. So is there a point where you can gain no more muscle? Even if say after 40 years of juicin you are taking maybe 10grams of gear a week. I'm just asking what if?

Bump

 

[gjohnson5]

I guess the better question is would one be able to keep healthy long enough to reach that point. Generally people here downplay issues such as blood pressure , lipids , triglycerides , liver enzymes, and other "minor" issues that arise when doing gear.

Kris Dimm just had a heart attack. I wonder how much he was doing??

So eventually as time goes by you put as much muscle as certain amout of anabolic androgenic steroids will produce so you do more and more and so on and so on. So is there a point where you can gain no more muscle? Even if say after 40 years of juicin you are taking maybe 10grams of gear a week. I'm just asking what if?

 

[Indy]

bump, someone with some knowledge on this please chime in, as i would also like to know how the receptors work and how long to "clear them"

You dont need to "clear them" if there are not enough receptors, the body can actually open more. A receptor is simply and "lock and key" type scenario, so once the the receptor has received the signal from the chemical it received the receptor is unlocked freeing it up. I do agree you get a "tolerance" to gear as I in no way get gains like I did 3 years ago so that's why you switch up gear in your cycles. People have the perception that you take gear and the receptor receives it's "key" and locks the receptor long term, that's not the case at all. Think about it, it's the same scenario for every hormone in your body whether introduced from internal or external source and your body never stops making them to function everyday, right ??

 

[mobro]

some very good post on this.

so instead of a "clean or not clean receptor" it's more a matter of increased tolerance without the same "side effects". but what regulates a person's tolerance level to a certain drug? if not receptors?
does make perfect sense to cycles shorter than 12 weeks for the reasons of tolerance, receptors, sides, and recovery. or at least in my opnion it does.

 

[mobro]

anybody got anything else?

 

[juniorsamples]

You're on the right track. It's more a matter of homeostasis. Taking any drug will lead to a tolerance but if you stay off long enough, the body normalizes and the drug is once again effective. Alcohol is a good example. Build up a tolerance and you can handle more and more. Even if you go off for a long time, if you start up again, it'll hit you a little harder but it won't be like when you first started drinking.

But remember, steroids aren't really "curing" anything. They're quite unique in that regard. Muscle growth is almost a "side effect" of the drugs purpose. The thing is, once you've put on X amount of muscle, you're less likely to have similar gains. That lessened effect really doesn't have anything to do with "receptor acceptance." It's the body's limited reaction to the effects.

Good post Nelson Montana.