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JohnnyO
New member
A specific type of protein actually.
http://story.news.yahoo.com/news?tm...e=7&u=/nm/20020419/sc_nm/science_obesity_dc_1
http://story.news.yahoo.com/news?tm...e=7&u=/nm/20020419/sc_nm/science_obesity_dc_1
Protein causes Obestity
- Thread starter JohnnyO
- Start date
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dballer
Guest
WASHINGTON (Reuters) - A protein that affects the body's ability to handle fat and sugar might offer a way to treat obesity and diabetes, if a way can be found to block it, scientists reported on Friday.
Mice genetically engineered to lack the protein can eat a high-fat diet and stay lean, the researchers report in this week's issue of the journal Developmental Cell.
If a way can be found to block this protein in humans, it may -- and the researchers stress the word may -- be a way to treat or prevent diabetes and obesity, they said.
"If you eat the same amount of food it will make you gain less weight," Dr. Benjamin Neel, of Harvard University and director of the cancer biology program at Beth Israel Deaconess Medical Center, said in a telephone interview.
"I want it too," he joked.
The protein, called PTP1B for protein tyrosine phosphatase 1B, joins a list of proteins and enzymes that in mice are associated with obesity. Many different small biotech firms and large pharmaceutical companies are pursuing them as potential diet pills.
One-quarter of Americans are obese and 60 percent are overweight, so the market potential is considerable.
Neel and colleagues genetically engineered mice that lack the PTP1B protein. The protein acts both on the hormone leptin, which is secreted by fat cells and strongly linked to obesity, and on insulin, they found.
The mice that lacked PTP1B, even those missing just one of their two copies of the gene that controls production of the protein, were hypersensitive to insulin.
"What was unanticipated, however, was that the mice were surprisingly lean," Neel said.
It seems that not having the gene increases the body's sensitivity to insulin and leptin, meaning the two hormones work more efficiently in smaller amounts. The result was a revved-up metabolism.
MICE LOOKED LIKE HIGHLY TRAINED ATHLETES
"A PTP1B knockout mouse has some of the characteristics of a highly trained athlete to the extent that they have increased energy expenditure," Neel said.
He hopes to develop a drug -- hopefully a pill -- that could block the effects of the PTP1B protein in people.
Obese people have too much leptin. In normal amounts, leptin can reduce appetite, but it appears that years of overeating causes the body to stop responding to the hormone.
There is a similar effect in insulin resistance, which precedes diabetes, and in type-2 diabetes, which affects 15 million Americans.
Blocking PTP1B just might be able to reverse these two effects, Neel hopes.
Neel is so hopeful that he has joined the board of a company called Ceptyr, a small biotech headquartered in Bothell, Washington that hopes to capitalize on the kind of work he is doing.
In this study Neel's team worked with Millennium Pharmaceuticals, and Ceptyr works with other big drug companies, such as Eli Lilly and Co.
There are other proteins that may have similar effects, if they work in people as they do in mice. Last year a team at the Whitehead Institute at the Massachusetts Institute of Technology (news - web sites) in Boston identified one called adipocyte complement-related protein (Acrp30), made by fat cells.
A team at GlaxoSmithKline and Cambridge University in Britain are working on one called Uncoupling Protein 3 (UCP3) that increases mouse metabolism.
Mice genetically engineered to lack the protein can eat a high-fat diet and stay lean, the researchers report in this week's issue of the journal Developmental Cell.
If a way can be found to block this protein in humans, it may -- and the researchers stress the word may -- be a way to treat or prevent diabetes and obesity, they said.
"If you eat the same amount of food it will make you gain less weight," Dr. Benjamin Neel, of Harvard University and director of the cancer biology program at Beth Israel Deaconess Medical Center, said in a telephone interview.
"I want it too," he joked.
The protein, called PTP1B for protein tyrosine phosphatase 1B, joins a list of proteins and enzymes that in mice are associated with obesity. Many different small biotech firms and large pharmaceutical companies are pursuing them as potential diet pills.
One-quarter of Americans are obese and 60 percent are overweight, so the market potential is considerable.
Neel and colleagues genetically engineered mice that lack the PTP1B protein. The protein acts both on the hormone leptin, which is secreted by fat cells and strongly linked to obesity, and on insulin, they found.
The mice that lacked PTP1B, even those missing just one of their two copies of the gene that controls production of the protein, were hypersensitive to insulin.
"What was unanticipated, however, was that the mice were surprisingly lean," Neel said.
It seems that not having the gene increases the body's sensitivity to insulin and leptin, meaning the two hormones work more efficiently in smaller amounts. The result was a revved-up metabolism.
MICE LOOKED LIKE HIGHLY TRAINED ATHLETES
"A PTP1B knockout mouse has some of the characteristics of a highly trained athlete to the extent that they have increased energy expenditure," Neel said.
He hopes to develop a drug -- hopefully a pill -- that could block the effects of the PTP1B protein in people.
Obese people have too much leptin. In normal amounts, leptin can reduce appetite, but it appears that years of overeating causes the body to stop responding to the hormone.
There is a similar effect in insulin resistance, which precedes diabetes, and in type-2 diabetes, which affects 15 million Americans.
Blocking PTP1B just might be able to reverse these two effects, Neel hopes.
Neel is so hopeful that he has joined the board of a company called Ceptyr, a small biotech headquartered in Bothell, Washington that hopes to capitalize on the kind of work he is doing.
In this study Neel's team worked with Millennium Pharmaceuticals, and Ceptyr works with other big drug companies, such as Eli Lilly and Co.
There are other proteins that may have similar effects, if they work in people as they do in mice. Last year a team at the Whitehead Institute at the Massachusetts Institute of Technology (news - web sites) in Boston identified one called adipocyte complement-related protein (Acrp30), made by fat cells.
A team at GlaxoSmithKline and Cambridge University in Britain are working on one called Uncoupling Protein 3 (UCP3) that increases mouse metabolism.
one thing that occurred to me on the way home is how amazing it is that all this research is going into finding proteins/drugs etc to stop type 2 diabetes or reduce obesity, or reduce CHD......
WHEN just not eating a fucking mcdonalds for every meal of the fucking day would probably cut the incidence in half minimum, and cost a whole lot less as well ?!?
WHEN just not eating a fucking mcdonalds for every meal of the fucking day would probably cut the incidence in half minimum, and cost a whole lot less as well ?!?
Norman Bates
New member
If it has less side effects than DNP or T3 it´s a good thing, also for BB.
I bet most people would use it while cutting.
I bet most people would use it while cutting.
HappyScrappy
New member
dballer said:
he noticed that they would start driving around in Escalades and snorting coke, beating up strippers, and shooting the drivers of their friend's limo - eventually falling into the downward cycle of alcoholism and finding themselves destitude on the streets, wondering what became of their lives.
ladymacbeth
New member
danielson said:
What do you think would happen if we all just went straight up Project Mayhem on Mickey Ds?
aurelius said:
tell me about it....
amazes me....you know most people (i think 95%) who get type 2 diabetes have NO incredible genetic dispositon towards it.
fair enough.....food manufacturers have made it tough on us by giving us refined sugars, processed meals etc, so a few people might get it
but come on.....this pill is being made for the lard arsses out there.....im not saying i dont feel sorry for them but this pill, its like saying you wanna walk from new york to boston via australia?!? the solution is SO EASY!!! stuff like this frustrates me
aurelius said:
you're making me feel old. i feel like i should know what you're saying, but i have no idea
project mayhem?!? computer game?!?
be kind. i was born idiot
danielson said:
you're making me feel old. i feel like i should know what you're saying, but i have no idea
project mayhem?!? computer game?!?
be kind. i was born idiot
We're not old.
We're just more experienced.
Yeah that's it.
and I'm more experienced than a lot of people here.
big4life said:
We're not old.
We're just more experienced.
Yeah that's it.
and I'm more experienced than a lot of people here.
i dont know. these kids and their '64bit gaming'......i remember when 8 bit was state of the art. and controllers only had 2 fire buttons, A and B. and everybody played duck hunt
actually i think im 1 year younger than LMB (i think shes 21). i STILL have no idea what she;s on about though. maybe im just stoopid
(BIG....chicks dig older men. and no matter how old you 'think' you are, you'll never be as old as wodin
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