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naturally anabolic
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am i misunderstanding it or is this true?
phytoestrogens natural weak anti-e's?
- Thread starter naturally anabolic
- Start date
Yes, it is true.
http://www.cuttingedgemuscle.com/Forum/showthread.php?s=&threadid=1248
Especially the study linked to in the thread:
http://jcem.endojournals.org/cgi/content/full/86/4/1750
Figure 4 shows how the estrogenic compound glyceollin binds to the estrogen receptor as an agonist, but displaces the much more potent estradiol. The net result is that glyceollin is an estrogen antagonist in the presence of estradiol. As the other study cited in the CEM link showed, genestein, another soy phytoestrogen, also displays antiestrogenic properties:
"Therefore, genistein appears to behave as a partial agonist; behaves as an agonist by itself, and as an antagonist in the presence of estrogen. However, daidzein did not display any estrogenic or antiestrogenic activity at the concentrations tested."
(1)
(1) Life Sci 2002 Jul 12;71(8):865-77
Inhibition of estrogenic stimulation of gene expression by genistein.
Ratna WN.
Division of Pharmacology, Toxicology and Medicinal Chemistry, Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY 11201, USA. [email protected]
http://www.cuttingedgemuscle.com/Forum/showthread.php?s=&threadid=1248
Especially the study linked to in the thread:
http://jcem.endojournals.org/cgi/content/full/86/4/1750
Figure 4 shows how the estrogenic compound glyceollin binds to the estrogen receptor as an agonist, but displaces the much more potent estradiol. The net result is that glyceollin is an estrogen antagonist in the presence of estradiol. As the other study cited in the CEM link showed, genestein, another soy phytoestrogen, also displays antiestrogenic properties:
"Therefore, genistein appears to behave as a partial agonist; behaves as an agonist by itself, and as an antagonist in the presence of estrogen. However, daidzein did not display any estrogenic or antiestrogenic activity at the concentrations tested."
(1)
(1) Life Sci 2002 Jul 12;71(8):865-77
Inhibition of estrogenic stimulation of gene expression by genistein.
Ratna WN.
Division of Pharmacology, Toxicology and Medicinal Chemistry, Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY 11201, USA. [email protected]
