Anthony Starks said:
Its not that confusing, all a halflife means is the time it takes for 1/2 of a drug to leave your system. All I did was carry that out for a standard cycle. If there is a part of my calculations that does not make sense to you I can explain it for you. But, unless the half-life of these esters is much shorter than stated (which is possible, I'm not a chemist), we are all doing PCT too soon.
Well, what you're really talking about here is the biological half-life which opens the door to all kinds of other questions. Also...it's not like you inject 1000mg of Test on day 1 and now you have 1000mg of active Test floating around in you. It’s more like you inject those 1000mg and day after day a certain percentage of carbon atoms are cleaved off thereby making some number of MG of Test available each day. So you need to reconsider your equations. The esterfied (is that a word?) test is essentially useless until such time that it’s freed up and then the test is actually rapidly utilized/bound/metabolized. If you take the nuclear decay approach to this problem you will end-up with the wrong answer, and wrong graph. To be honest, I’ve attempted to get someone to verify my approach to be correct…I never got much back but here goes...
Normally we consider half-life decay to be represented by the following equation: A=A(i)e^(kt). Where A(i) is the initial quantity, k is the decay constant and t is the elapsed time. Let’s assume that you are using Test-cyp with a half-life of about 8days, I’ve read anything from 6 to 8dy but Pfizer says 8dy, so we will go with 8dy. Thus, in this case, k=-.08664. So you inject 1000mg on day 1…then you must have 500mg on day 8. Sure, sorta. It’s NOT as if you have 500mg of Test readily available for utilization on dy8. Not at all.
On day one you will have 917mg remaining in depot and 83mg having been released.
On day two you will have 841mg remaining in depot and 76mg having been released in the past day and so on.
As you can see the amount remaining in depot is decaying at the half-life rate, but the amount getting released each day, and doing the inhibition of HPTA, is actually going down. Unfortunately, I am definitely
not even remotely self-educated in pharmakenetics.
There's TONS of stuff I simply don't understand regarding bio-activity of drugs...keep that in mind, take this all with a gain of salt. I have attempted to illustrate such with nuclear decay after starting out by saying that nuclear decay doesn’t really represent the real world action of biological half-life. Still, I have found this approach to better approximate the graphs shown form baseline Test levels following an injection of Test Cyp. Take this graph for instance
(link) which shows 10dy after a single 140mg injection of CYP you are back to baseline levels and by my approach you are in fact seeing the benefit of about 6mg of Test released each day. Point being, you end-up with less test interfering with recovery sooner after your last injection than the opposite approach would indicate.
Once you get below 200mg of esterfied (there’s that word again) Test in your body you generally start seeing inhibition drop off. This should equate to something in the mid-teens for MG/day. It’s not like you have and on off switch for HTPA, it’s more like a sliding scale and for most people (only repeating what I’ve read HRT doc’s say) recovery begins when esterfied levels start falling below 200mg. Graph it out and see where you would begin your recovery based on this approach. Using that approach, you end-up being able to consider recovery long about week 14 or one month post last injection.
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