Here are a couple cut and pastes that may help..
GH is regulated in a pulsatile manner. It's released from the pituitary in response to GHRH from the hypothalamus....once GH is released, it carries out its actions, one of which is causing increased expression of IGF-1, primarily in the liver. it's IGF-1 that's the main negative feedback inhibitor of further GH release.....as long as there is sufficient serum IGF-1 levels, somatostatin is expressed, which prevents GHRH from causing further release of GH. Normal GH pulses occur about every 4-5 hrs, so taking exo GH (or LR3) will suppress 1-2 pulses if taking GH, 2-4 if using LR3. Once these compound are at low enough levels again, somatostatin expression is reduced and GHRH predominates and causes further GH release from the pituitary, and the normal pulse pattern resumes.........
There really is no recovery period from GH, because you're never fully suppressing the HP axis regarding GH....you're only doing so for part of the day, unless you're doing very high doses of GH or dosing E4hrs or so. Using LR3 >1x/day can also cause suppression for a full day, but even then, i don't think there would be any long term problems.
and another
There is no recovery from GH that same as with Testosterone but with high doses, your body does have to kick in normal GH production again, especially if you are taking it twice per day. There are also other areas of concern that differ for different age groups and different sexes. The heart tends to be sensative to GH and for that reason, most people take some time off from the use of GH. Fusion of the bones is only a concern in the pediatric population. Gigantia is a concern of mainly the adult male population, etc. Most of the studies that I know of are done with renal patients and short statured people. I do know of one studie done with bodybuilders, but because they didn't follow them through the entire career or GH use, there weren't sure how much of the heart enlargement was from the GH use or just a part of being a bodybuilder (who tend to have enlarged hearts anyway). The advice that any doctor will give you is to only take it 5-6 days per week and not to go more than 3-4 months before taking a week or two off. As you get older, your body tends to produce less and less GH, if you inject synthetic GH into your system, you are giving it a reason to produce less GH on it's own and the longer you take it, the less your body may be able to synthesize GH at it's optimal level. This is why we tend to give recomendations that are way into the SAFE zone.
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