I'd advise rotating sites as often as possible. I generally recommend someone putting 2 squirts on the inside bicep/elbow of each arm and 1 on each intercostal for 3 days. Then the next three days switching it up to the backs of the knee and shoulder area. This will minimize any drying effect it may have. One+ is an excellent value. I have more feedback from users who did ONE and 4Aderm (which is the same thing). I guess people feel that can dose it out more correctly than someone else.