Noopept...experiences from a long term user

[John Juan]

Noopept: King of the Nootropics

Like most nootropic users, you likely supplement with nootropics because you want to become more efficient and more effective in your work or studies. And, if you're using nootropics to become better at what you're doing, it stands true that you also want to achieve the nootropic effect as proficiently as possible, right? If you're using racetams or thinking about trying a nootropic, then it's time to check out a very potent alternative, noopept. On the flip side, if you are using nootropics, there's also a good chance you could skyrocket the effectiveness of your current stack by adding noopept. Though it's not a brand new supplement, noopept is rightfully considered by many to be the king of nootropics.

What is Noopept?
Originally discovered in Russia, Noopept is a nootropic that also has neuroprotective properties and is available in the United States as a dietary supplement. It comes from the racetam family which is known for piracetam, aniracetam, pramiracetam, and oxiracetam. All of these are well known for their cognitive boosting properties. Noopept, however, packs a much larger punch and is 1000x stronger than piracetam, the most recognized of the racetam family. This gives it the advantage of providing more of the positive effects at a much lower dosage.

How Does Noopept Work?
Noopept has high oral bioavailability and easily crosses the blood-brain barrier. After consumption, noopept reaches the brain in about 15 minutes. It works like piracetam by having a strong reaction on glutamatergic AMPA receptors where it binds itself and allows the glutamate to move easily between brain cells.

Benefits of Noopept
So what exactly does Noopept do for you? When a supplement is this powerful, there are far reaching effects. The benefits cover the entire cognitive performance spectrum. They can generally be grouped into three categories: learning and memory, neuroprotection, and relieving of cognitive damage.

Learning and memory:

Enhanced drive and motivation.
Improved memory, learning ability, and recall. Compared to piracetam, Noopept enhances not only the memory consolidation stage but also the memory retrieval steps.
Helps catalyze the associative connections formation and improve communications between the right and left hemispheres of the brain.
Neuroprotection:

Helps reduce damage to the brain brought by oxidative stress the same as human neurons apopsis
An anti-oxidant that has an antagonizing effect on calcium excess.
Promotes brain health:

Can be used to relieve effects of brain injuries, ischemia, and prenatal damage
Improves age-related mental degeneration and decline
Can help with amnesia.

 

[John Juan]

Noopept and Learning: Noopept stimulates the release of certain neurotransmitters in the brain that are known to boost brain power when it comes to learning and memory. This is one of the reasons for which noopept is most sought-after. According to research and reviews, Noopept dramatically improves performance in all three areas of memory including formation, retrieval and restoration. When taking noopept, you will find it easier to recall new concepts learned as well as make associations with different concepts on several levels at once. If you often find yourself forgetting new information very shortly after hearing it for the first time, this supplement can boost levels of the Acetylcholine neurochemical which transmits signals between your different neurons. This results in better synapse plasticity which means your brain can form more connections and also improve reasoning and problem solving skills.

 

[John Juan]

GYM EXPERIENCE FROM NOOPEPT USER

In the gym, my focus has been otherworldly, and to be honest that’s where I’m most happy with it’s effects. It’s getting to the point that if I didn’t have anything else to do I would be in there for three hours. You just don’t want to stop. You have weights in front of you, so you lift them, again and again, tiredness be damned. More reps. More PRs. More sets. It doesn’t increase anything physically but mentally you’re god damned determined and nothing is getting in your way.

 

[John Juan]

Noopept is available in liquid oral form

 

[John Juan]

Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats).

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2008 Jul;146(1):77-80.

Affiliation
Abstract
Experiments on adult Wistar rats showed that injection of beta-amyloid25-35 (2 microg) into Meynert basal nuclei caused long-term memory deficiency which was detected 24 days after this injection by the memory trace retrieval in conditioned passive avoidance reflex (CPAR). The effects of noopept, an original nootropic and neuroprotective dipeptide, on the severity of this cognitive deficiency were studied. Preventive (for 7 days before the injury) intraperitoneal injections of noopept in a dose of 0.5 mg/kg completely prevented mnestic disorders under conditions of this model. Noopept exhibited a significant normalizing effect, if the treatment was started 15 days after the injury, when neurodegenerative changes in the basal nuclei, cortex, and hippocampus were still acutely pronounced. The mechanisms of this effect of the drug are studied, including, in addition to the choline-positive effect, its multicomponent neuroprotective effect and stimulation of production of antibodies to beta-amyloid25-35. Noopept efficiency in many models of Alzheimer disease, its high bioavailability and low toxicity suggest this dipeptide for further studies as a potential agent for the treatment of this condition (initial and moderate phases).

 

[John Juan]

Noopept stimulates the expression of NGF and BDNF in rat hippocampus.

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2008 Sep;146(3):334-7.

Affiliation
Abstract
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus. Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis. Taking into account the fact that pharmacological activity of Noopept is realized after both acute and chronic treatment, we studied the effect of single and long-term treatment (28 days) with this drug. Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression. In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept. Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect. These changes probably play a role in neuronal restoration. We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer's disease, but also at the stage of mild cognitive impairment (pre-disease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer's disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer's disease.

 

[John Juan]

One of the most important things to remember is that Noopept does not appear to accumulate in the body or cause any type of drug dependency or addiction despite its potency.

 

[John Juan]

BENEFITS OF NOOPEPT

increased ability to learn

improved mood

decreased anxiety and feelings of depression

increased levels of energy and wakefulness

improved physical performance

improved memory and recall

improved patterns of speech

better logical thinking

enhanced perception and reflexes

improved sleep patterns

 

[John Juan]

[The original novel nootropic and neuroprotective agent noopept].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. Article in Russian.

Affiliation
Abstract
The paper describes pharmacological properties of the new nootropic drug noopept created using an original approach based on the imitation of a nonpeptide nootrope structure by means of the short-peptide design. In particular, the structure of pyracetam was designed using dipeptide nootropes. Experimental investigations of noopept (N-phenylacetyl-L-polyglycine ethyl ester) showed that the new drug exceeds pyracetam both with respect to the effective dose level (1000 times lower for noopept than for pyracetam) and in the spectrum of mnemotropic activity. In contrast to pyracetam facilitating only the early stages of the memory process, noopept positively influences the memory consolidation and retrieval steps as well. The new drug produces an additional selective anxiolytic action. The pronounced neuroprotective effect of noopept was demonstrated both in vivo (in cases of various forms of brain ischemia) and in vitro (on various neuronal models). The drug action is based on the antioxidant effect, the antiinflammatory action, and the ability to inhibit the neurotoxicity of excess calcium and glutamate, and to improve the blood rheology. It was established for the first time that the activity of noopept is retained both upon parenteral introduction and upon peroral administration, which is a principal advantage of this proline-containing dipeptide over other, more complex peptides. This property provided a basis for the development of a medicinal form of noopept for peroral usage. At present, noopept tablets (noopept 5 and 10 mg) are under clinical assessment as a means of treating cognitive deficiency of cerebrovascular and post-traumatic origin.

 

[John Juan]

[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2010 Dec;73(12):2-5. Article in Russian.

Affiliation
Abstract
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and hypothalamus has been studied in rats. Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus. The content of BDNF protein in the hypothalamus was also somewhat increased. In the context of notions about the activation of stress-induced kinases, as an important factor of amyloidogenesis and tau-protein deposition in brain tissue, and the role of deficiency of the neurotrophic factors in the development of neurodegenerative processes, the observed decrease in the activity of stress-activated MAPKs and increased expression of BDNF as a result of noopept administration suggest thatthis drug hasaspecific activity withrespect to some pathogenetic mechanisms involved in the Alzheimer disease.

PMID 21395007 [PubMed - indexed for MEDLINE]