New 1-Tu. . .

[Fortes]

Ummm . . . Andriol's normal standard dosage is usually between 240-300 mg per DAY. The BV is somewhere between 3% and 6%, and those aren't conservative estimates. That comes out to about 30-50 mg of testosterone actually making it into the bloodstream daily . . .

. . . which comes out to about 400 mg of active testosterone weekly.

My guess is that 100-200 mg of 1-Testosterone Undecanoate daily would be comparably as effective, but hey, that's my GUESS. It may be less or more.

 

[javaguru]

Ummm . . . Andriol's normal standard dosage is usually between 240-300 mg per DAY. The BV is somewhere between 3% and 6%, and those aren't conservative estimates. That comes out to about 30-50 mg of testosterone actually making it into the bloodstream daily . . .

I think your math was a little off. If you consume 300 mg per day with 6% absorption you'll get (300*.06) 18mg per day or 126mg per week. I'm concerned about the cost effectiveness of the 1-TU product.

 

[WannaBPowerful]

I dont understand what all this mg per week talk. Is that a good amount to absorb? How effective does it look to be?

 

[javaguru]

Nobody knows its effectiveness. Now if it could be converted into a painless injectable we might have a winner. It's solubility would be very high and it would have a very long half life.

 

[WannaBPowerful]

What is half-life?

How do you know it would be more effective as an injectable?
I dont think they make legal suppliments as injectables lol.
How can you tell all this info about solubility and mg's and stuff? Is its makeup listed somewhere?

 

[javaguru]

half life

n : the time required for something to fall to half its initial value.


Half life is the amount of time it takes for half of the current amount of the drug to be metabolized and made inactive. Injectables allow nearly 100% of the drug to make it into circulation. No, supplement companies don't make their supplements into injectables but many consumers do make bulk powder into injectables. If you go to http://www.mesomorphosis.com there are articles explaining the function of esters. The Undeanoate ester dramatically increases solubility which allows greater amounts of the drug to be dissolved in oil but also lowers the amount of actual drug delivered per mg due to the ester adding weight.

 

[Par Deus]

I think your math was a little off. If you consume 300 mg per day with 6% absorption you'll get (300*.06) 18mg per day or 126mg per week. I'm concerned about the cost effectiveness of the 1-TU product.

As well you should be.

Here is an excerpt from an article I wrote that reviews the literature:

T = Testosterone, no ester
TU = Testosterone undecanoate
100mg TU contains 63mg of testosterone.

Study 1:

Females were given 25mg T or 40mg TU dissolved inh oil. No mention of food. Bioavailability of T was found to be 3.66% vs. 6.83% for TU -- an increase of a mere 3% -- and peak levels were almost identical (28).

Study 2:

Hypogonadal (low testosterone levels)males were given 63mg of T or 100mg of TU or 100mg of TU with arachis oil. TU, with or without oil, achieved testosterone levels of 450ng/ml vs. 300 ng/ml -- a difference of only 50% -- no mention of whether it was taken with a meal or not.(29)

It should be noted, in regards to both of the above studies, that testosterone slearance from the blood is higher in eugonadal males (our target audience) than in hypogonadal males or females (30, 31) -- 675 l/day for hypogonadal vs. 1288 l/day for eugonadal, and dose corrected values indicate an area under curve that is 4-fold lower in men than women, following testosterone administration (29,32).

Study 3:

Eugondal (normal testosterone levels) males received 100mg of TU w/oil which resulted in testosterone levels of 6.4ng/ml, up from a baseline of 4.5ng/ml. Given the pharmacokinetics of TU, this would be equivalent to about 3-4% bioavailability -- no better than that of free testosterone (34).

Study 4:

Eugonadal males were given 63mg T or 100mg TU or 100mg TU dissolved in arachis oil with breakfast or without (32). T showed an increase of 12.5nm/l w/breakfast and 10nm/l without -- this represented a 40% higher area under curve than baseline. TU showed an increase of about 6-7nm/l w/meal and only 1nm/l without. It was actually LOWER than T!!! TU w/oil, on the other hand, increased by 25nm/l with a meal, and 11nm/l without. This is a decent study for the ethergels (4-6% bioavailability for TU vs. 2-3% for T), but very damning for the powder ether products. It should also be noted that the meal was 474kcal, 59% of which was fat -- this equals 31 grams of fat!! And, we have discussed the importance of fat for absorption.

Study 5:

Eugonadal males received 129mg TU w/oil which resulted in an increase in testosterone from 200pmol/l to 500pmol/l, with significant elevation for 6 hours. Given the 4 doses needed to keep levels elavated for 24 hours, one would need about 500mg per day. Given 5-10 mg per day needed to produce a eugonadal state and that 129mg of TU is equal to 81mg of testosterone, we get a bioavailability of 4-8%. Also, this was given with breakfast -- it does not say what kind, but one would assume it was the "standard" 31 grams of fat breakfast (35).




28. Eur J Drug Metab Pharmacokinet 1986 Apr-Jun;11(2):145-9 Related Articles, Books, LinkOut Absolute bioavailability of testosterone after oral administration of testosterone-undecanoate and testosterone. Tauber U, Schroder K, Dusterberg B, Matthes H.

30. Eur J Clin Invest 1977 Apr;7(2):145-7 Related Articles, Books, LinkOut Influence of sex, testicular development and liver function on the bioavailability of oral testosterone. Nieschlag E, Cuppers HJ, Wickings EJ.

31. J Clin Endocrinol Metab 1967 May;27(5):686-94 Related Articles, Books, LinkOut Mean plasma concentration, metabolic clearance and basal plasma production rates of testosterone in normal young men and women using a constant infusion procedure: effect of time of day and plasma concentration on the metabolic clearance rate of testosterone. Southren AL, Gordon GG, Tochimoto S, Pinzon G, Lane DR, Stypulkowski W.

32. Eur J Clin Pharmacol 1979 Nov;16(5):345-9 Related Articles, Books, LinkOut Bioavailability of oral testosterone in males. Frey H, Aakvaag A, Saanum D, Falch J.

34. Acta Endocrinol (Copenh) 1975 Sep;80(1):179-87 Related Articles, Books, LinkOut Testosterone undecanoate: a new orally active androgen. Hirschhauser C, Hopkinson CR, Sturm G, Coert A.

35. Acta Endocrinol (Copenh) 1983 Mar;102(3):456-62 Related Articles, Books, LinkOut Saliva and serum testosterone following oral testosterone undecanoate administration in normal and hypogonadal men. Schurmeyer T, Wickings EJ, Freischem CW, Nieschlag E.

 

[pa1ad]

I think your math was a little off. If you consume 300 mg per day with 6% absorption you'll get (300*.06) 18mg per day or 126mg per week. I'm concerned about the cost effectiveness of the 1-TU product.

You are also forgetting something very important. the molecular weight of TU (and 1-TU) is 445, and the MW of test and 1-T is 288

Do the math. Every gram of TU yields only a fraction of actual T