Myostatin!!

[bigorse]

so myostatin and its inhibition is a very big topic in bodybuilding at the moment. we have products such as folli, ace, myo hmp, yk11 etc that have the possibility of myostatin inhibition.

but why are we so concerned with its inhibition? myostatin in human is significantly lower than the levels of those in the animals these were tested on and myostatin shows possible il side effects on the heart and tendons (not that health is the forefront of most of our concerns, though it should still be somewhere in the equation!)

who has experience here with any myostatin inhibitors and what is everyones thoughts on the idea? i am curious to see everones opinions and some studies on it. i have done plenty of reading and am intrigued but i think the jury is still out.

where i believe it may be beneficial is short Bursts of inhibitors towards the end of long cycles where myostatin is at its highest.

okay, lets hear everyone's thoughts!

 

[bigorse]

bump

 

[Jimmyinkedup]

I am pretty interested in this new YK11. Its not only a myo inhibitor but a sarm as well. Also it is a lot more anabolic than most sarms. Its def of interest to me.

 

[bigorse]

I am pretty interested in this new YK11. Its not only a myo inhibitor but a sarm as well. Also it is a lot more anabolic than most sarms. Its def of interest to me.

have done so much reading on myo hmp and follistatin but there are so many conflicting views on them! maybe one of the sponsor sights could get some loggers going on these differe myo inhibitors esp. yk11 as it is extremely unknown.

 

[Jimmyinkedup]

have done so much reading on myo hmp and follistatin but there are so many conflicting views on them! maybe one of the sponsor sights could get some loggers going on these differe myo inhibitors esp. yk11 as it is extremely unknown.

That would be great. I dont often get excited about new products that come to market. I feel like most of them are hype and false hope but I have to say Im using mk677, and it really works, and I am really excited about this yk11. Its so different from anything I have ever seen that I cant help but be really curious about it.

 

[j_p]

personally I am very excited with this compound YK11 also!
I think myo-inhib will be a big thing and it is already going in that direction. I agree it could help out cycles effectively for sure. Cant wait to see more and more feed back on it

 

[bigorse]

has anyone tried any of peptides like folli? are the price tags justifiable?

 

[Barhead]

Well I will be trying the YK11 so ill post up what I think eventually. It seems like a very promising compound so I am excited!

 

[bigorse]

Well I will be trying the YK11 so ill post up what I think eventually. It seems like a very promising compound so I am excited!

yeah, get a log going if you can! il follow it. good luck with your run

 

[Jimmyinkedup]

I am tempted to try yk myself. Im just trying to figure out how to best incorporate it.
I am running mk677 & cjc w/dac right now and have no intention of stopping.
What I have been thinking about doing is running a tried and true cycle, one I know what i can expect from and add in the yk11. This will allow me to see what kind of difference, if any, the YK11 brings to the table. I am thinking that would be the fairest way for me personally to judge its effectiveness. If I were to run my standby test/deca/winstrol cycle I could add in the yk and get a darn good idea how effective it is. I can almost tell you right now what I would get out of the cycle alone having run it so many times in my present condition. The only thing is then to really be fair I would have to drop the mk/cjc stack and to be honest I just do not want to do that. Quite frankly I am loving that combo. I only pin E3D with it and am getting some really nice gh/igf benefits.
Decisions, decisions.....

 

[bigorse]

I am tempted to try yk myself. Im just trying to figure out how to best incorporate it.
I am running mk677 & cjc w/dac right now and have no intention of stopping.
What I have been thinking about doing is running a tried and true cycle, one I know what i can expect from and add in the yk11. This will allow me to see what kind of difference, if any, the YK11 brings to the table. I am thinking that would be the fairest way for me personally to judge its effectiveness. If I were to run my standby test/deca/winstrol cycle I could add in the yk and get a darn good idea how effective it is. I can almost tell you right now what I would get out of the cycle alone having run it so many times in my present condition. The only thing is then to really be fair I would have to drop the mk/cjc stack and to be honest I just do not want to do that. Quite frankly I am loving that combo. I only pin E3D with it and am getting some really nice gh/igf benefits.
Decisions, decisions.....

well from what i have read myostatin inhibition should allow proliferation easier. (il try sight a study) so using something like your current gh stack plus some MGF should make YK even more effective. anabolic wise there are animal studies showing hyperplasia from tren so if you were going an all out blast based on the hope for muscle proliferation i would reccomend something like this

1-indefinitely your gh peps stack
1-4 and 8-12 pegMGF 200mcg eod
1-12 tren a where your comfortable
1-12 test prop where your comfortable
yk11 through out.

that would be how i see it most effective.

the other would be incorporated into long cycle like deca/eq cycle. gains ussually slow around week 10, myostatin inhibition is what seems to be the causr so inhibiting it should allow for continued gains in longer cycles.

1-16 test e 500mg
1-16 deca 500mg
8-16 yk11

this is where i see it beneficial.

 

[bigorse]

pub med abstract on myostatin deficient animals

Abstract

Myostatin, which is a member of the TGF-beta superfamily, is a negative regulator of skeletal muscle formation. Double-muscled Piedmontese cattle have a C313Y mutation in myostatin and show increased skeletal muscle mass which resulted from an increase of myofiber number (hyperplasia) without that of myofiber size (hypertrophy). To examine whether this mutation in myostatin gene affects muscle development in a dominant negative manner, we generated transgenic mice overexpressing the mutated gene. The transgenic mice exhibited dramatic increases in the skeletal muscle mass resulting from hyperplasia without hypertrophy. In contrast, it has been reported that a myostatin mutated at its cleavage site produces hypertrophy without hyperplasia in the muscle. Thus, these results suggest that (1) the myostatin containing the missense mutation exhibits a dominant negative activity and that (2) there are two types in the dominant negative form of myostatin, causing either hypertrophy or hyperplasia.

 

[j_p]

Yes please post up logs guys! I would love that myself!