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MohawkMuscle
Guest
Is What are your votes?
M.d.
Should we really trust this new supplement? Supposedly it blocks the myostatin in your body, so in theory that if it blocks the myostatin then once will grow muscle. If it does what the label claims and does block myostatin, what implications will this have on the body and its functions? Will the heart grow to an unhealthy size, will the inhibited myostatin cause cell duplication to go out of control, and what if it causes already mutated cells “cancer” to replicate much faster then is natural? Anyone out there a M.D. and could answer some of these questions.
Should we really trust this new supplement? Supposedly it blocks the myostatin in your body, so in theory that if it blocks the myostatin then once will grow muscle. If it does what the label claims and does block myostatin, what implications will this have on the body and its functions? Will the heart grow to an unhealthy size, will the inhibited myostatin cause cell duplication to go out of control, and what if it causes already mutated cells “cancer” to replicate much faster then is natural? Anyone out there a M.D. and could answer some of these questions.
riskybizz007
New member
Very good questions you raise... bumpin for info.
I'll pass and wait.....
Still, a recent study did indicate that there is a role for myostatin in adult humans; in fact, their conclusion reads, "...the detection of myostatin in post-natal skeletal muscle, combined with studies of humans with wasting diseases, provide strong circumstantial evidence for the role of myostatin in regulating muscle growth after birth, and future studies will be crucial in the further understanding of myostatin." But make no mistake, the supplement Cytoseira canariensis suggested to cause myostatin inhibition lacks any human research. So although there's definite evidence that myostatin has a powerful impact on muscle growth in humans, there's no evidence that we can, as of yet, take advantage of that knowledge.
Still, a recent study did indicate that there is a role for myostatin in adult humans; in fact, their conclusion reads, "...the detection of myostatin in post-natal skeletal muscle, combined with studies of humans with wasting diseases, provide strong circumstantial evidence for the role of myostatin in regulating muscle growth after birth, and future studies will be crucial in the further understanding of myostatin." But make no mistake, the supplement Cytoseira canariensis suggested to cause myostatin inhibition lacks any human research. So although there's definite evidence that myostatin has a powerful impact on muscle growth in humans, there's no evidence that we can, as of yet, take advantage of that knowledge.
edgecrusher
New member
If we did have something powerful enough to take advantage of the myostatin gene, it would not be sold OTC.
riskybizz007
New member
Thing is most of the non-OTC's today once were sold over the counter. Still I'm wondering if this product would work at all, I've seen more and more ads on it and not only Biotest makes it now. Guess we have to wait to see who will try it 1st around here. 
serge
New member
Myostatin
by Grendel
The Bull stands there, confident, powerful, in control of himself and his situation. He is the master of his domain and all he surveys. His powerful muscles ripple beneath paper-thin skin; there is almost no fat on his body. He swaggered over to a heifer and she flicks her ears seductively. Yes, it's good to a Belgian blue. That money he spent on his Charles Atlas program was well worth it, he reflects. In America, first you get the muscles, and then you get the women.
I am sure many of you have seen pictures of the Belgian Blue cow similar to the one above, the so-called "double muscled cow." This cow has an incredible amount of muscle tissue and is the result of selective breeding. The magic behind this cow is the myostatin gene[1] [2] which, when "knocked out" permits the muscles of the cow to grow unchecked. The early influence of the myostatin gene was seen in mice as early as 1987[3]. Myostatin is part of the super-family of growth factors; these genes encode for secreted chemicals that regulate, in humans, embryonic development and tissue homeostasis (in adults). While myostatin plays a huge role in embryo development, it still has an impact on developed skeletal muscle. Myostatin controls not only fiber size but also fiber number; think of this as controlling, for our purposes, both size and strength. Interestingly enough, muscle tissue in mice that have been exercised shows an increase in myostatin[4] levels while the muscle of mice during recovery shows a decrease in myostatin levels[5].
It does not take an advanced degree in biology to see that being able to control the expression of the myostatin gene would be a tremendous breakthrough. And, for bodybuilders, the ability to control myostatin levels would permit unprecedented muscular development. Now the problem is that many times what works in animals will not work in humans; this is the case with adrenal stimulants like clenbuterol that produce muscle growth in cattle but not humans because we lack one type of adrenal receptor.
Therefore, just because we can have extremely muscular mice or cows, does that mean we can do the same to humans?
Fortunately, humans do have a myostatin gene, but the question still remains, will a mutation, limitation, or alternation of this gene have any impact on human muscular development? Some research has allegedly been done on Flex Wheeler, a top-level professional bodybuilder, by BALCO Laboratories, Inc. The research, according to a statement available on the Internet, indicated that Mr. Wheeler "Was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this
landmark study have already been submitted for publication."
Taking all this information in can be overwhelming. It sounds almost like science fiction, doesn't it? But then again, if you look in the context of the gym, there has always been a clear line of people who possesses what was simply called "great genetics." In addition to naturally higher hormone levels, it appears likely that these people have other genetic anomalies, which explain their superior physiques (caveat: of course training is crucial, but we all have that friend who is naturally big and ripped without much effort while we slave away). Myostatin appears to be one of the usual suspects; the lower the levels of myostatin expression in a person, the bigger their muscle can get (put simply).
So let run out and stop our myostatin gene from being expressed. Oh, wait.You would have to alter your genetic code and that would take genetic engineering wouldn't it? Sorry, but we are just not at the point where we can casually snip out segments of DNA; if we were, we would have eradicated many diseases and conditions that have plagued mankind for centuries. Research is underway, of course. If you want to help, BioVendor
Laboratories has your human myostatin research kit (or will have it soon). See if you can't unravel the mystery that is facing the top geneticists in the world during "Who Wants to Be A Millionare."
Why am I being so flippant when I speak of the difficulty involved in turning the information we have on myostatin into something applicable for humans? I am being so sarcastic because supplement companies are now claiming to have been able to develop a product, available over-the-counter for an ungodly price, that will manipulate myostatin. Fortunately, these companies do not yet have the audacity to claim that their pill can alter
your genetic code, one company which intends to release a myostatin inhibiting product acknowledges that this would, at this point, involve really only selective breeding which is only a viable option for animals (unless we travel back to Germany during the 1940s)
So what is the rationale behind this new line of products that will be coming soon to a store near you? The line these companies are advancing has to do with the distinction between the myostatin gene and the proteins the gene codes for. The proteins run around the body and stop the production of new muscle cells (in adults). While these supplement
companies are keeping silent on how their product will work, I am sure that is has to do with these proteins and somehow neutralizing them. Sounds pretty impressive for a supplement company, even ones with millions and millions of dollars (cough choke gasp) to spend on research and development considering that no major international pharmaceutical company (say, Roche or Upjohn) or major University (Johns Hopkins) has come close to doing this. I am waiting for a supplement company to cure AIDS, screw this doctor stuff, let's get the presidents of the supplement companies together
and put them in charge of curing epidemics like AIDS and cancer.
What is even more miraculous is that, in order for this product to be sold as a supplement, it will come from a food source otherwise, guess what, it's a drug and you have to get this little thing called FDA approval (but whose looking anyway, right). The one company that does have a product like this out uses a "marine plant extract" called Cystoseira canariensis. Do I need to say anything more? This algae has been available in nutritional supplements for a long time and for a lot less than these new myostatin "inhibitors".
The bottom line is that the very idea of this supplement line is ludicrousto me. I might be able to believe that, in a few years, a major pharmaceutical company will come out with a product that might, in some way, achieve this claim. Even if this were possible, would it be safe? While the supplement companies will, of course, claim that there are no
adverse side effects from their myostatin inhibitor, does that seem logical
>to anyone? Here is a new product which effects an entire class of protein intimately involved in muscle growth, regeneration, and regulation. This product can produce tremendous muscle gains (or whatever the claim is) but without side effects. Sure.
I hate to be "that guy" but hopefully I can cause anyone considering these over-priced sea animal products to reconsider. Remember the 1980s? Remember, oh, OKG or plant sterols? Well, this is the second coming of that degree of marketing hype. There are no independent studies showing any impact of any drug, let alone marine extract, on human myostatin or the proteins coded for by the myostatin gene. I am eagerly waiting to see what studies are alleged to back these new product claims and what species they were performed in University of Central Afghanistan, Extracts from Sea Creatures make Star Fish, Flounders, and Snakes big as HELL AND RIPPED TO due to inhibition of myostatin encoded protein.
by Grendel
The Bull stands there, confident, powerful, in control of himself and his situation. He is the master of his domain and all he surveys. His powerful muscles ripple beneath paper-thin skin; there is almost no fat on his body. He swaggered over to a heifer and she flicks her ears seductively. Yes, it's good to a Belgian blue. That money he spent on his Charles Atlas program was well worth it, he reflects. In America, first you get the muscles, and then you get the women.
I am sure many of you have seen pictures of the Belgian Blue cow similar to the one above, the so-called "double muscled cow." This cow has an incredible amount of muscle tissue and is the result of selective breeding. The magic behind this cow is the myostatin gene[1] [2] which, when "knocked out" permits the muscles of the cow to grow unchecked. The early influence of the myostatin gene was seen in mice as early as 1987[3]. Myostatin is part of the super-family of growth factors; these genes encode for secreted chemicals that regulate, in humans, embryonic development and tissue homeostasis (in adults). While myostatin plays a huge role in embryo development, it still has an impact on developed skeletal muscle. Myostatin controls not only fiber size but also fiber number; think of this as controlling, for our purposes, both size and strength. Interestingly enough, muscle tissue in mice that have been exercised shows an increase in myostatin[4] levels while the muscle of mice during recovery shows a decrease in myostatin levels[5].
It does not take an advanced degree in biology to see that being able to control the expression of the myostatin gene would be a tremendous breakthrough. And, for bodybuilders, the ability to control myostatin levels would permit unprecedented muscular development. Now the problem is that many times what works in animals will not work in humans; this is the case with adrenal stimulants like clenbuterol that produce muscle growth in cattle but not humans because we lack one type of adrenal receptor.
Therefore, just because we can have extremely muscular mice or cows, does that mean we can do the same to humans?
Fortunately, humans do have a myostatin gene, but the question still remains, will a mutation, limitation, or alternation of this gene have any impact on human muscular development? Some research has allegedly been done on Flex Wheeler, a top-level professional bodybuilder, by BALCO Laboratories, Inc. The research, according to a statement available on the Internet, indicated that Mr. Wheeler "Was a participant in a study we recently conducted in collaboration with the Department of Human Genetics at the University of Pittsburgh involving 62 men who made unusually large gains in muscle mass in response to strength training (extreme responders). Flex was one of only nine extreme responders that had the very rare "myostatin mutation." Myostatin is the gene that "limits muscle growth." Specifically, Flex had the rarest form of myostatin mutation at the "exon 2" position on the gene. This simply means Flex has a much larger number of muscle fibers compared to the other subjects or the normal population. We believe that these are the very first myostatin mutation findings in humans and the results of this
landmark study have already been submitted for publication."
Taking all this information in can be overwhelming. It sounds almost like science fiction, doesn't it? But then again, if you look in the context of the gym, there has always been a clear line of people who possesses what was simply called "great genetics." In addition to naturally higher hormone levels, it appears likely that these people have other genetic anomalies, which explain their superior physiques (caveat: of course training is crucial, but we all have that friend who is naturally big and ripped without much effort while we slave away). Myostatin appears to be one of the usual suspects; the lower the levels of myostatin expression in a person, the bigger their muscle can get (put simply).
So let run out and stop our myostatin gene from being expressed. Oh, wait.You would have to alter your genetic code and that would take genetic engineering wouldn't it? Sorry, but we are just not at the point where we can casually snip out segments of DNA; if we were, we would have eradicated many diseases and conditions that have plagued mankind for centuries. Research is underway, of course. If you want to help, BioVendor
Laboratories has your human myostatin research kit (or will have it soon). See if you can't unravel the mystery that is facing the top geneticists in the world during "Who Wants to Be A Millionare."
Why am I being so flippant when I speak of the difficulty involved in turning the information we have on myostatin into something applicable for humans? I am being so sarcastic because supplement companies are now claiming to have been able to develop a product, available over-the-counter for an ungodly price, that will manipulate myostatin. Fortunately, these companies do not yet have the audacity to claim that their pill can alter
your genetic code, one company which intends to release a myostatin inhibiting product acknowledges that this would, at this point, involve really only selective breeding which is only a viable option for animals (unless we travel back to Germany during the 1940s)
So what is the rationale behind this new line of products that will be coming soon to a store near you? The line these companies are advancing has to do with the distinction between the myostatin gene and the proteins the gene codes for. The proteins run around the body and stop the production of new muscle cells (in adults). While these supplement
companies are keeping silent on how their product will work, I am sure that is has to do with these proteins and somehow neutralizing them. Sounds pretty impressive for a supplement company, even ones with millions and millions of dollars (cough choke gasp) to spend on research and development considering that no major international pharmaceutical company (say, Roche or Upjohn) or major University (Johns Hopkins) has come close to doing this. I am waiting for a supplement company to cure AIDS, screw this doctor stuff, let's get the presidents of the supplement companies together
and put them in charge of curing epidemics like AIDS and cancer.
What is even more miraculous is that, in order for this product to be sold as a supplement, it will come from a food source otherwise, guess what, it's a drug and you have to get this little thing called FDA approval (but whose looking anyway, right). The one company that does have a product like this out uses a "marine plant extract" called Cystoseira canariensis. Do I need to say anything more? This algae has been available in nutritional supplements for a long time and for a lot less than these new myostatin "inhibitors".
The bottom line is that the very idea of this supplement line is ludicrousto me. I might be able to believe that, in a few years, a major pharmaceutical company will come out with a product that might, in some way, achieve this claim. Even if this were possible, would it be safe? While the supplement companies will, of course, claim that there are no
adverse side effects from their myostatin inhibitor, does that seem logical
>to anyone? Here is a new product which effects an entire class of protein intimately involved in muscle growth, regeneration, and regulation. This product can produce tremendous muscle gains (or whatever the claim is) but without side effects. Sure.
I hate to be "that guy" but hopefully I can cause anyone considering these over-priced sea animal products to reconsider. Remember the 1980s? Remember, oh, OKG or plant sterols? Well, this is the second coming of that degree of marketing hype. There are no independent studies showing any impact of any drug, let alone marine extract, on human myostatin or the proteins coded for by the myostatin gene. I am eagerly waiting to see what studies are alleged to back these new product claims and what species they were performed in University of Central Afghanistan, Extracts from Sea Creatures make Star Fish, Flounders, and Snakes big as HELL AND RIPPED TO due to inhibition of myostatin encoded protein.
serge said:
I would venture a guess that that article is copyrighted.
You should post an excerpt and then provide a link to the full article at www.anabolicextreme.com -- where the article is from.
Scaggs
New member
I'm one of those guys who are stupid enough to try all this hyped up crap. Really only because i didn't want to Start AS untill i had 2 years training and a solid base before starting a cycle. So in the meantime i tried mostly all the PH's and Patches. I've learned they're not worth the money at all.
I'm on my second bottle of Myostatin by Champion Nutrition. I havn't seen any significant results in strength or size. Im growing like i would be normally. The only thing i can say is that i got a bad stomach virus a few weeks back and didn't eat for about 5 days. i lost some more fat around my waist but didn't lose any muscle mass. my measurements were the same. the only thing i had in those 5 days were my mystatin pills, water, tea, and chicken broth a few times oh and lots of NyQuil. So was it the mystatin that helped me retain my mass, i don't know...
I'm leaning more towards hype. Thats too bad because it sound like a great thing.
Scaggs
I'm on my second bottle of Myostatin by Champion Nutrition. I havn't seen any significant results in strength or size. Im growing like i would be normally. The only thing i can say is that i got a bad stomach virus a few weeks back and didn't eat for about 5 days. i lost some more fat around my waist but didn't lose any muscle mass. my measurements were the same. the only thing i had in those 5 days were my mystatin pills, water, tea, and chicken broth a few times oh and lots of NyQuil. So was it the mystatin that helped me retain my mass, i don't know...
I'm leaning more towards hype. Thats too bad because it sound like a great thing.
Scaggs
M
MohawkMuscle
Guest
Oh shit!!!
You will never stop growing!!!!
Your fucked now!
hehe dont worry, we all fall to hype at times. Remember Boron and hotstuff? Or am I just getting old?
You will never stop growing!!!!
Your fucked now!
hehe dont worry, we all fall to hype at times. Remember Boron and hotstuff? Or am I just getting old?
W
WARBIRDWS6
Guest
funny thing, i have been using myostat for about 3 or 4 months. i get so many compliments on how great i look now.........BUT.....i also did a Looooooooong cutting cycle of MAG-10 and ergo Nordiol spray with arimidex, and clomid after. Plus i started training harder, and did my usual high protein diet. Then i also have been on 30mg D-bol for a week or so....plus i have been taking MD6/CLA/R-ALA for a long while. So basically, who the fuck knows if the myostat helped? lol. i just kept ordering it with my other biotest stuff, just because. i was brainwashed i think. maybe i should stop taking it.......or maybe it is helping.........
W
WARBIRDWS6
Guest
Scaggs said:
yeah, i hear ya. i work two days at 4.5 hours a shift at this GNC i have worked at for 8 years. i get wholesale cost products, and my wages go directly to pay my "bill" for supps. no taxes or nothing, just have a list of supps taken and hours worked. so its pretty cool to have a job that is just dedicated to getting supps. makes it easy. especially when its at GNC cost. as long as the myostat fits into the monetary situation, and doesn't throw me over the top.....i'll just continue to take it. wish i could have given it a myostat only run. but who the hell uses only one new supp for 3-6 months as they suggest? its impossible i tell you.
now i need a job dedicated to getting "pharmaceuticals". 
iv been taking the myo-blast for 1 week now, and have been taking anotesten , nortesten, acetabolan2, and cell-tech for 4 weeks and im alot leaner and gaining good weight approx 10 pounds or more strength is jumping up .
i l let u guys no how the myo-blast does for me in a couple weeks
i l let u guys no how the myo-blast does for me in a couple weeks
Scaggs
New member
iv been taking the myo-blast for 1 week now, and have been taking anotesten , nortesten, acetabolan2, and cell-tech for 4 weeks and im alot leaner and gaining good weight approx 10 pounds or more strength is jumping up .
i l let u guys no how the myo-blast does for me in a couple weeks
Yea you got too many variables there. Creatine itself can give you those results. I put 10 lbs one in a week with loading and cycling creatine. it was mostly all water. when i came off of it i dropped all that wieght fast.
I don't think im taking myostim again. this will be my last bottle when im finished with it. then maybe i'll notice something being off it. but as far as i can tell. its not worth the $$$
Scaggs
i l let u guys no how the myo-blast does for me in a couple weeks
Yea you got too many variables there. Creatine itself can give you those results. I put 10 lbs one in a week with loading and cycling creatine. it was mostly all water. when i came off of it i dropped all that wieght fast.
I don't think im taking myostim again. this will be my last bottle when im finished with it. then maybe i'll notice something being off it. but as far as i can tell. its not worth the $$$
Scaggs
well i think something other than the cell-tech is working because i stay pumped im lean not holding much water people say im taking the roids i eat really clean . During the past while on cell-tech i gained some weight but didnt stay pumped like now. the only other creatin i have taken was the power creatin by champion nutrition which i hold alot of water with it gain about 15 lbs with
Scaggs
New member
I just started cycling creatine again. its been since this past Monday and i already put on 4 lbs. I hold water so easily with Creatine. When you cycle your cell tech, do you drink tons of water? i do. Creatine needs it to fill the muscle cells.
Everyday I feel more and more that Myostim is a scam. Think about it.... its not even the same branch of a myostatin suppressor as the one they used on the mice and cows. And has never even been really tested on humans. Either the real myostim they used on space trips for astronauts is too expensive for the market or... they want slower results. otherwise it would be your last supplement you would need to purchase. Aimed at taking your money. I think its a scam.
Scaggs
ya i drink tons of water and only water , but im also taking hydroxycut which kinda halts the water retention but my weight is steadily going up and arms are fuller and lean not bloated looking. maybe myo-blast works for me but not for you who knows but il keep updating about the myo-blast
I have about 6 days left on Myo-Blast, and Iam pretty dissapointed. I havent seen squat for gains in any category. Word on the street is that this is a long time supplement meaning you need to take it for awhile before you see results, but at its price, screw that. Not worth the money, just my 2 cents.
Spiral Traveller
New member
Myostat is bullshit. The ONLY substance proven to block the myostatin gene's effects is follistatin. Nothing else will do the job. Period.
Simon Keller
New member
Never trusted Biotest, never will!!!!
FunkMasterFlex
New member
i guess someone will have ot loa on it for 2 months...then stop lifting while still taking it....and see what happens. I did hear that a customer was sick for 2 weeks and didnt lose a lb. But i think i hear he has a blood clot on his brain. SO... i dont know to may vairables, but the anti-catabolic thing seems to be the only correlation seemingly worth while
You're all being played for a bunch of chumps. Doesn't that bother you?
The stuff these companies sell isn't even the real myostatin inhibitor. It's some seaweed horseshit that has some similarities in structure to the real chemical. In other words, it's about as similar as "sterols" are to "steroids."
You'd be better off using boron. Seriously. At least it has some nutritional value. (Helps in preventing osteoperosis and tooth decay)
The stuff these companies sell isn't even the real myostatin inhibitor. It's some seaweed horseshit that has some similarities in structure to the real chemical. In other words, it's about as similar as "sterols" are to "steroids."
You'd be better off using boron. Seriously. At least it has some nutritional value. (Helps in preventing osteoperosis and tooth decay)
SANDMAN5150
New member
Gentleman, just my 2 cents...after all the posts regarding the MYO-SHIAT and scams that all these supplement companies are producing I would thin that none of you would go out and by it actually of you do a search on this board and/ir ask about supplement reliability there is someone out there that has been rode on....I mean scammed and can provide feedback I keep reading and I thin kto my self imagine all that money being invested on this Seaweed/kelp and they show these "subject" like that guy on Champion nutrition performing a most muscular in black trunks where there is this before picture and then this after picture and this bastard is straight fucking huge gained a "Shredded 20 pounds".
Nelson Montana said:
Furthermore, even if you were able to obtain the real chemical AND if it really worked in humans AND if it were orally bio-available (all big IFs), you'd have to take it from the time you were born until the time you reached adulthood and then continue taking it as long as you were working out for it to have any significant effect. But, as you pointed out, it's a moot point since the stuff that these companies are selling is simply dried algae and not the purified compound.
N
Necrophagia
Guest
LOL I seen a add for this shit in Muscle Media. The add said "results occur after 1 year of use." LOL. Uhhuh. I am sure there are some dumbasses that'll buy it and take it for a year expecting to blow up like the Hulk after a year.
LOL!!This cracked me up!!!
