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My blood test problem: C-reactive protein

Triple J

New member
I just got an extensive workup through life extension foundation, the "male panel". Here are some of the results (I'll provide my levels followed by the reference ranges).

Considering my age (44) my T levels were not too bad:
free T: 11.2 (6.8 - 21.5) optimal >16<21
estradiol: 27 (0-53)
total T: 534 (241-827)
DHEA: 155 (95-530) optimal >400<600​
Comments: I was on 500mg T/wk for 6months or so from November-2003 to March-2004. I will start taking DHEA and add a small dose of anti-estrogen (adex, femara, or examastane) to try to boost my total and free T levels.

Cholesteral was pretty good, too:
Total: 182 (100-190) optimal >180<200
HDL: 52 (40-59)
Triglycerides: 65 (0-149)
LDL: 117 HIGH (0-99)​
Comments: according to my research, my LDL is not a big concern, because the ratio of TG:HDL is good. The closer to 1 the better and my reading is at 1.25. This indicates the majority of your LDL consists of the larger fragments which are not considered a risk factor.

Here is the PROBLEM:
C-reactive protein: 5.88 HIGH (0-3) optimal <1​
Comments: C-reactive protein is a measure of inflammation in the body. This level puts me at 3X normal risk of a cardiovascular event. I have been plagued by aches and pains that have curtailed my ability to train effectively for about the last year. The aches and pains have been getting better since I got off the juice. The natural treatment protocol includes fish oil, DHEA, vitamin C, and Vitamin E. Otherwise an aspirin a day may be helpful, too. I'll probably have a consult with the life extension doc next week. My guess is I will go on a protocol for a few months and then get retested. I'll report whatever advice/program he suggests.

Comments, help or suggestions, anybody?
 
Last edited:
Triple J said:
I just got an extensive workup through life extension foundation, the "male panel". Here are some of the results (I'll provide my levels followed by the reference ranges).

Considering my age (44) my T levels were not too bad:
free T: 11.2 (6.8 - 21.5) optimal >16<21
estradiol: 27 (0-53)
total T: 534 (241-827)
DHEA: 155 (95-530) optimal >400<600​
Comments: I was on 500mg T/wk for 6months or so from November-2003 to March-2004. I will start taking DHEA and add a small dose of anti-estrogen (adex, femara, or examastane) to try to boost my total and free T levels.

Cholesteral was pretty good, too:
Total: 182 (100-190) optimal >180<200
HDL: 52 (40-59)
Triglycerides: 65 (0-149)
LDL: 117 HIGH (0-99)​
Comments: according to my research, my LDL is not a big concern, because the ratio of TG:HDL is good. The closer to 1 the better and my reading is at 1.25. This indicates the majority of your LDL consists of the larger fragments which are not considered a risk factor.

Here is the PROBLEM:
C-reactive protein: 5.88 HIGH (0-3)​
Comments: C-reactive protein is a measure of inflammation in the body. This level puts me at 3X normal risk of a cardiovascular event. I have been plagued by aches and pains that have curtailed my ability to train effectively for about the last year. The aches and pains have been getting better since I got off the juice. The C-reactive protocol for natural treatment includes fish oil, DHEA, vitamin C, and Vitamin E. Otherwise an aspirin a day may be helpful, too. I'll probably have a consult with the life extension doc next week. My guess is I will go on a protocol for a few months and then get retested. I'll report whatever advice/program he suggests.

Comments, help or suggestions, anybody?

I wouldn't worry to much about it. It is perfectly normal for everybody to have increased levels. It is a pretty generic test for inflammation, and non-specific. Considering that when you work out you are breaking down muscle fibers higher levels in bodybuilders is to be expected.
 
I don't think there is any evidence supporting the assumption that bodybuilders have elevated CRP levels.

I am definitely sure that there have been no clinical trials concluding that elevated bodybuilder CRP levels are in any way less predictive of an adverse cardiovascular event than elevated CRP in non-bodybuilders.

However, the concept of inflammation being a significant factor in cardiovascular disease (ie. as compared to the accepted factors like hypertension, diabetes, and high cholesterol) is relatively new and has not been studied enough to draw definite conclusions.

Tholdren
 
The concept is not new at all. Its just that medicine moves like glaciers in the ice age - slow but powerfully. It has been about 3 years since Mayo clinic has endorsed the idea - but 15 years ago I was taught that CRP is a marker for heart disease (ultra quant version) and a marker for pretty much all major diseases. I wrote published articles 10 years ago about CRP and heart disease.

It is an established fact that what triggers most MI's is inflammatory. Most MI's (heart attacks) are not from cholesterol slowing clogging an artery. There is usually a nidus of cholesterol - however it is the acute inflammatory response that causes the heart attack.

I have posted here off an on for years under various handles. I am sure I am the first one ever to post about calcium-D-glucurate, vitex (chasteberry) etc, years ago.

Here is another one that I am sure I am the first to post and you will see more of in the future - although probably not for at least 5 years-as medicine moves very slowly to change: One of the best predictors for a heart attack is your fitness level and recovery. If you do a stress test (attach a person to a EKG and have them run on a treadmill (or alternatively give them an injection to stimulate a heart rate increase) - it is their fitness level and recovery level that best predict a upcoming coronary (heart) event. Here is a simple way you can test it : get on a cardio machine that will give you your output in METS. Give it your best.

If you average 7.5 METS you are about average for a heart attack (but consider the average person dies of a heart attack as MI's kill every other person - or roughly 50% of all annual deaths). If you average under 7.5 METS please don't plan what you are going to do for next years spring break. If you average 14 or so your chances are very slim. Regardless of your cholesterol level. This test has proven to be more significant than even the latest imaging that can view how much plaque is in your heart arteries.

The next is recovery rate - give it your best on the treadmill or whatever. Then hop off and rest for 2 minutes. If your heart rate drops at least 55 BPM you are fairly well protected. you are even more protected if your heart rate drops lets say 65 BPM (like from 170 BPM at the peak of your exercise to 105 in 2 minutes.

These 2 at home tests are not as accurate as a stress test done in a doctors office, but they are pretty darn close.
 
The CRP test is sometimes used in patients with inflammatory bowel disease and some forms of arthritis and autoimmune diseases to assess how active the inflammation is and to monitor the treatment. The CRP test is also used to monitor patients after surgery or other invasive procedures to detect the presence of an infection during the recovery period. CRP tests are not specific enough to diagnose a particular disease. Rather, CRP is a general marker of infection and inflammation that alerts medical professionals that further testing and treatment may be necessary.

When is it ordered?
Because CRP increases in cases of inflammation, the test is ordered when acute inflammation is a risk (such as from an infection after surgery) or suspected based on patient symptoms. It is also ordered to help evaluate conditions, such as rheumatoid arthritis and lupus. The test may be repeated to determine whether treatment of an inflammatory disease is effective since CRP levels drop as inflammation subsides.

CRP also is used to monitor wound healing and to monitor patients who have surgical cuts (incisions), organ transplants, or burns as an early detection system for possible infections.

What does the test result mean?
A high or increasing amount of CRP in your blood suggests that you have an acute infection or inflammation. In a healthy person, CRP is usually less than 10 mg/L. Most infections and inflammations result in CRP levels above 100 mg/L.

If the CRP level in your blood drops, it means that you are getting better and inflammation is being reduced.

When your results fall below 10 mg/L, you no longer have clinically active inflammation.
PLEASE NOTE: Numerically reported test results are interpreted according to the test's reference range, which may vary by the patient's age, sex, as well as the instrumentation or kit used to perform the test. A specific result within the reference (normal) range – for any test – does not ensure health just as a result outside the reference range may not indicate disease. To learn more about reference ranges, please see the article, Reference Ranges and What They Mean. To learn the reference range for your test, consult your doctor or laboratorian. Lab Tests Online recommends you consult your physician to discuss your test results as a part of a complete medical examination.

Is there anything else I should know?
Another test to monitor inflammation is called the erythrocyte sedimentation rate (ESR). Both tests give similar information about the presence of inflammation. However, CRP appears and then disappears sooner than changes in the ESR. Thus, your CRP level may fall to normal if you have been treated successfully, such as for a flare-up of arthritis, but your ESR may still be abnormal for a while longer.

1. What are chronic inflammatory diseases?
Chronic inflammatory diseases are diseases that lead to the development of long-lasting or frequently recurring inflammation. They can be caused by a number of different pathological conditions. Examples include arthritis, lupus, and inflammatory bowel disease (Crohn’s disease).

2. What is the difference between regular CRP and hs-CRP tests?
Both tests measure the same molecule in the blood. The high sensitivity CRP (hs-CRP) test, which measures very low amounts of CRP in the blood, is ordered for seemingly healthy people to help assess their risk for heart problems. It measures CRP in the range from 0.5 to 10 mg/L. The regular CRP test is ordered for patients at risk for bacterial or viral infections (such as following surgery) or patients with chronic inflammatory diseases (such as rheumatoid arthritis). It measures CRP in the range from 10 to 1000 mg/L.
 
What is METS and what does it stands for?

how long should one give it's best on the the treadmill?
 
Thx drjmw very informative - my test was hsCRP, and generally in your view, a result of 5 or so is not a big concern? Life extension considers this a level where risk is increased (their optimal value < 1) but recommends repeated tests to verify trend (makes me wonder just how volatile this marker is, i.e. does it go up from common exercise, allergies, etc?)

I am planning to be re-tested in a couple months. There are a few things I am going to implement between now and then. DHEA and fish oil, daily baby aspirin, greater vitamin C&E intake, and perhaps a round of antibiotics.
 
Your local doc should be able to adequately advise you regarding CRP results. This is his forte. I am no expert on CRP--just what I read.
 
More info on hsCRP:

How is it used?
hs-CRP is most often used to help predict a healthy person's risk of cardiovascular disease.
People who have hs-CRP results in the high end of the normal range have 1.5 to 4 times the risk of having a heart attack as those with CRP values at the low end of the normal range.

The CRP molecule itself is not a harmful molecule in the body. The higher level of CRP is simply a reflection of higher than normal inflammation. The measurement of CRP does not reflect where the inflammation is. It may come from cells in the fatty deposits in arterial walls that reflect the process of atherosclerosis. It may come from other tissues.

When is it ordered?
Unfortunately, there is no agreement about exactly when the test should be ordered and on whom the test should be done. There is not yet a consensus about its value, but the test is being promoted by some as a test to help determine risk for cardiovascular disease, heart attacks, and strokes.
hs-CRP usually is ordered as one of several tests in a cardiovascular risk profile, often along with tests for cholesterol and triglycerides. Some experts say that the best way to predict risk is to combine a good marker for inflammation, like CRP, along with the ratio of total cholesterol to HDL cholesterol.

To help clarify when CRP testing may be most useful, in January 2003 the American Heart Association and Centers for Disease Control and Prevention (AHA/CDC) examined current evidence and then published their recommendations for its use:

No: not for widespread screening of the general adult population; continue to focus on major risk factors, such as high blood pressure, high cholesterol, smoking and diabetes
Yes: useful as an independent marker of risk and as a “discretionary tool” in the evaluation of those with moderate risk of cardiovascular disease to help determine treatment course
No: not for tracking treatment efficacy due to lack of evidence that reducing hs-CRP levels improves outcomes, such as survival

What does the test result mean?
The results are generally interpreted on a relative scale. People with the highest values have the highest risk of cardiovascular disease and those with the lowest values have the lowest risk. This is often expressed in terms of percentiles. These may be quintiles (five divisions), quartiles (four divisions), or tertiles (three divisions). For example, one large study showed that those people in the top quintile of CRP (the 20% of people with the highest CRP values) have about twice the risk of heart disease as those people in the bottom quintile (the 20% of people with the lowest CRP values).
The AHA/CDC defined risk groups as follows:

Low risk: less than 1.0 mg/L
Average risk: 1.0 to 3.0 mg/L
High risk: above 3.0 mg/L
PLEASE NOTE: Numerically reported test results are interpreted according to the test's reference range, which may vary by the patient's age, sex, as well as the instrumentation or kit used to perform the test. A specific result within the reference (normal) range – for any test – does not ensure health just as a result outside the reference range may not indicate disease. To learn more about reference ranges, please see the article, Reference Ranges and What They Mean. To learn the reference range for your test, consult your doctor or laboratorian. Lab Tests Online recommends you consult your physician to discuss your test results as a part of a complete medical examination.

Is there anything else I should know?
Taking nonsteroidal anti-inflammatory drugs (like aspirin, Advil, Motrin, and Naproxin) or statins (a class of cholesterol-lowering drugs) may reduce CRP levels in blood. Both anti-inflammatory drugs and statins may help to reduce the inflammation, thus reducing CRP.
Because hs-CRP tests are measuring a marker of inflammation, it is important that any person having the test be healthy in order for the test to be of any value in predicting the risk of coronary disease or heart attack. Any recent illness, tissue injury, infection, or general inflammation will raise the amount of CRP and give a falsely elevated estimate of risk.

Since the hs-CRP and CRP tests measure the same molecule, people with chronic inflammation, such as those with arthritis, should not have hs-CRP levels measured. Their CRP levels will be very high due to the arthritis—often too high to be measured using the hs-CRP test.
 
I have attached an article below gives a definition of METS and some insight into treadmill testing, and also a link to an article on treadmill testing.

But basically most stress testing follows the "Bruce" protocols. There is no specified exact time the test takes. They start you off walking and every 2 or 3 minutes they increase the difficulty of the test by changing the elevation of the treadmill or resistence of the stationary bike. They stop the test if you develop bad signs like dizziness or if the EKG you are hooked up to shows abnormal rhythms....or when you achieve 85% of your predicted maximal heart rate.

So basically take about 10-12 minutes to work up to a good running pace on a treadmill, then give it your maximal effort - all you can for a minute or two- at your maximal effort you should be around your 85% predicted maximal heart rate-and at that time note what your heart rate is and what your maximal MET performance was (mine is about 17 METS when I am really kicking it). Then hop off the treadmill and rest for 2 minutes. Then check your pulse again - this is hard to do at the gym since you have to get back on the machine and pedal again to get the machine working so you can check your pulse, and by pedalling again you are elevating your heart rate. So it is better to check your pulse manually after the maximal exertion - take your pulse for 10 seconds and multiply by 6 or take your pulse for 15 seconds and multiply times 4 etc.

But you don't want to end up doing 45 minutes of cardio or something before giving your maximal effort because you will have accrued some oxygen debt and your heart rate will take longer to return to normal because of that. 20 minutes total of testing is more than enough - you really can get a good idea in 15 minutes.

no matter what your results are you can improve them - have no doubt about that. Risk for heart disease is a fluctuating thing - in fact it fluctuates day by day and hour by hour (not trying to be scarey) - statistics show that most heart attacks occur around 5-7 AM and more often on Monday mornings - the point being that risk factors are modifiable. Research indicates that for every one MET improvement in treadmill performance there is a 12% increase in survival. The best way to improve treadmill performance is getting on a treadmill regularly. Cardio exercise reduces cardiac risk regardless - that is why cardio rehab is so important to a patient after they have a heart attack. So even if you have a dismal set of risk factors today, literally in a number of weeks or months you could alter the course of your life and have a very favorable profile

Link : http://www.heartsite.com/html/regular_stress.html

Article:
GIBBONS ET AL., 2002 GUIDELINE UPDATE FOR EXERCISE TESTING
Circulation 2002;106:1883-1892
ACC/AHA 2002 Guideline Update for Exercise Testing—Summary Article

A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Excercise Testing Guidelines)

Modification III

This revised text incorporates new published evidence on elderly patients, heart-rate responses during and after exercise, and systolic blood pressure responses during and after exercise. It replaces material in the original text that appeared under the major heading "Risk Stratification" and the subheading "Nonacute Coronary Artery Disease" beginning on page 278 (second column).

The value of exercise treadmill testing for prognostic assessment in elderly subjects has been described in the Olmstead County, Minnesota, cohort followed by the Mayo Clinic.14 As expected, the elderly patients (aged greater than or equal to 65 years) had more comorbidity and achieved a lower workload than their younger counterparts. They also had a significantly worse unadjusted survival. Workload expressed as metabolic equivalents (METs) was the only treadmill variable associated with all-cause mortality in both groups (adjusting for clinical prognostic variables), whereas both workload and exercise angina were associated with cardiac events (death plus myocardial infarction) in both groups. A positive ST response was not prognostic in the older patients when tested as a binary variable. Quantitative ST-segment deviation with exercise was apparently not available in this cohort, and the Duke Treadmill Score was not computed in this study.

Morrow and colleagues15 developed a prognostic score using data from 2546 patients from Long Beach Veterans Administration Hospital. This score includes 2 variables in common with the Duke treadmill score (exercise duration or the MET equivalent and millimeters of ST changes) and 2 different variables (drop in exercise systolic blood pressure below resting value and history of congestive heart failure [CHF] or use of digoxin [Dig]). The score is calculated as follows:

5 × (CHF/Dig [yes = 1; no=0]) + exercise-induced ST depression in millimeters + change in systolic blood pressure score - METs,

where systolic blood pressure_0 for an increase greater than 40 mm Hg, 1 for an increase of 31 to 40 mm Hg, 2 for an increase of 21 to 30 mm Hg, 4 for an increase of 0 to 11 mm Hg, and 5 for a reduction below standing systolic preexercise blood pressure. With this score, 77% of the Long Beach Veterans Administration Hospital population were at low risk (with less than 2% average annual mortality), 18% were at moderate risk (average annual mortality, 7%), and 6% were at high risk (average annual mortality, 15%).

Several studies have highlighted the prognostic importance of other parameters from the exercise test. Chronotropic incompetence, defined as either failure to achieve 80% to 85% of the age-predicted maximum exercise heart rate or a low chronotropic index (heart rate adjusted to MET level), was associated with an 84% increase in the risk of all-cause mortality over a 2-year follow-up in 1877 men and 1076 women who were referred to the Cleveland Clinic for symptom-limited thallium treadmill testing.16,17 The Cleveland Clinic investigators have also demonstrated the prognostic importance of an abnormal heart rate recovery pattern after exercise testing. Defined as a change from peak exercise heart rate to heart rate measured 2 minutes later of less than or equal to 12 beats per minute, an abnormal heart rate recovery was strongly predictive of all-cause mortality at 6 years in 2428 patients referred for thallium exercise testing.18 Similar trends have been suggested for a delayed systolic blood pressure response after exercise, defined as a value greater than 1 for systolic blood pressure at 3 minutes of recovery divided by systolic blood pressure at 1 minute of recovery. This finding was associated with severe CAD in a study of 493 patients at the Cleveland Clinic who had both symptomlimited exercise testing and coronary angiography (within 90 days). In a study of 9454 consecutive patients, most of whom were asymptomatic, the Cleveland Clinic investigators reported that abnormal heart rate recovery and the Duke treadmill score were independent predictors of mortality.20 Further work is needed to define the role of chronotropic incompetence, abnormal heart rate recovery, and delayed blood pressure response in the risk stratification of symptomatic patients relative to other well-validated treadmill test parameters.

In patients who are classified as low risk on the basis of clinical and exercise testing information, there is no compelling evidence that an imaging modality adds significant new prognostic information to a standard exercise test. In this regard, a distinction should be made between studies that show a statistical advantage of imaging studies over exercise ECG alone and studies that demonstrate that the imaging data would change practice (eg, by shifting patients from moderate- to low- or high-risk categories). Because of its simplicity, lower cost, and widespread familiarity in its performance and interpretation, the standard treadmill ECG is the most reasonable exercise test to select in men with a normal resting ECG who are able to exercise. In patients with an intermediate-risk treadmill score, myocardial perfusion imaging appears to be of value for further risk stratification. Patients with an intermediate-risk treadmill score and normal or near-normal exercise myocardial perfusion images and normal cardiac size are at low risk for future cardiac death and can be managed medically.




© 2002 by the American College of Cardiology Foundation and the American Heart Association, Inc.
 
Generic MALE said:
The next is recovery rate - give it your best on the treadmill or whatever. Then hop off and rest for 2 minutes. If your heart rate drops at least 55 BPM you are fairly well protected. you are even more protected if your heart rate drops lets say 65 BPM (like from 170 BPM at the peak of your exercise to 105 in 2 minutes.
I want to add soemthing since this qoute of mine may give some people uneeded cause for concern. At this time an ABNORMAl heart rate recovery is defined as a drop of less than 12 BPM one minute after exercise has been terminated. Anything over 12 BPM is considered technically "normal". However the faster your recovery the better - it is a sign of a more conditioned, a better functioning cardiovascular system. But I do not want anyone to worry if their recovery is only 30-40 BPM - that is still well within the normal range. But with improved conditioning you reduce your risks more, and improve your chances of surviving a heart attack (which at this time kills every other American).

This is because the main initial risk of a MI is hypoxia (low oxygen) to the cardiac muscle and necrosis (death) of the heart muscle afterwards. [of course after the initial heart attack clots/emboli and myocardial rupture and reduced cardiac output leading to generalized systemic hypoxia and other side effects of the initial heart attack come into play] Having a cardiac and vascular system that is highly conditioned to make the most of the oxygen we breath in gives us a better chance of survival since it means we will continue to process oxygen well.

Anyway, here is an excerpt from New England Journal of Medicine about the "abnormal" heart rate recovery:

Volume 341:1351-1357 October 28, 1999 Number 18

Heart-Rate Recovery Immediately after Exercise as a Predictor of Mortality

Christopher R. Cole, M.D., Eugene H. Blackstone, M.D., Fredric J. Pashkow, M.D., Claire E. Snader, M.A., and Michael S. Lauer, M.D.

ABSTRACT

Background : The increase in heart rate that accompanies exercise is due in part to a reduction in vagal tone. Recovery of the heart rate immediately after exercise is a function of vagal reactivation. Because a generalized decrease in vagal activity is known to be a risk factor for death, we hypothesized that a delayed fall in the heart rate after exercise might be an important prognostic marker.

Methods For six years we followed 2428 consecutive adults (mean [±SD] age, 57±12 years; 63 percent men) without a history of heart failure or coronary revascularization and without pacemakers. The patients were undergoing symptom-limited exercise testing and single-photon-emission computed tomography with thallium scintigraphy for diagnostic purposes. The value for the recovery of heart rate was defined as the decrease in the heart rate from peak exercise to one minute after the cessation of exercise. An abnormal value for the recovery of heart rate was defined as a reduction of 12 beats per minute or less from the heart rate at peak exercise.



Generic's comment - the idea that the alteration in heart rate is due to vagal tone is now considered a bit outdated and innacurate - but nonetheless 12 BPM per minute reduction in heart rate one minute after exercise is the minimum reduction required not to be considered a "dead man walking" with an MD. This article was written in 1999 - half a decade ago - which is the stone age with how fast new information is being discovered
 
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