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there was a post a while ago about zinc and the androgenic receptor wich was very informative
i think this just adds a little
http://clinical.caregroup.org/altmed/interactions/Nutrients/Zinc.htm
Zinc
Common Names: Zinc acetate, Zinc aspartate, Zinc citrate, Zinc gluconate, Zinc glycerate, Zinc oxide, Zinc picolinate, Zinc sulfate
Clinical Name: Zinc
Summary
Zinc
chemical name: Zn
forms: Zinc acetate, Zinc citrate, Zinc glycerate, Zinc picolinate, Zinc sulfate.
overview of interactions:
• nutrient affected by drug: Captopril
• nutrient affecting drug performance: Ciprofloxacin
• nutrient affected by drug: Corticosteroids, including Prednisone
• nutrient affected by drug: Oral Contraceptives
• nutrient affected by drug: Penicillamine
• nutrient affected by drug: Ranitidine (Zantac®)
• nutrient affecting drug performance: Tetracyclines
• nutrient affected by drug: Valproic Acid
• nutrient affecting drug performance: Warfarin
metabolism:
• Actively transported, zinc is regulated, in part, by sulfur containing amino acids.
• Zinc absorption is enhanced by soy protein, red wine, glucose, and lactose.
• Zinc absorption is inhibited by iron, copper, and phytates.
• Zinc is stored in muscle, spleen, bone marrow and liver. Both red blood cells and white blood cells contain high concentrations of zinc. Other tissues with high zinc concentrations are the skin, prostate, and retina (especially the macula).
function:
• Zinc is involved in the synthesis of cholesterol, protein, and fats. In addition, it regulates the release of vitamin A from the liver.
• Zinc affects cell growth, especially the epithelial tissue.
• Prostate reproductive health require zinc. Zinc inhibits the activity of 5-alpha-reductase, the enzyme that irreversibly converts testosterone to dihydrotestosterone, a form of testosterone that binds most strongly to prostate tissue causing hypertrophy.
• Zinc is required for vision.
• Zinc is also needed as:
an antioxidant cofactor for SOD;
a cofactor for alcohol metabolism;
a cofactor for delta 6 desaturase --> PGE1 synthesis.
• Insulin function requires zinc.
• The immune system uses zinc.
• Zinc is crucial for taste perception.
• Zinc provides protection against heavy metal toxicity, such as cadmium and lead, as well as copper toxicity as in Wilsons Disease.
dietary sources: Oysters, herring, sunflower and squash seeds, hard cheese, poultry, peanuts, meats, eggs, wheatgerm, soy meal, hard wheat berries, wheat bran, buckwheat, rice bran, millet, whole wheat flour, oatmeal, brown rice, cornmeal, black-eyed peas, green beans, chickpeas, lima beans, spinach, green onion, green leafy vegetables, sprouted grains.
Note: Food processing removes a large proportion of zinc as well as other trace elements.
deficiency:
• Zinc deficiencies tend to occur in alcoholics and individuals with chronic kidney disease, malabsorption problems, and sickle cell anemia. Researchers have found that low-income pregnant women and pregnant teenagers at greater risk for marginal zinc deficiencies and consequent adverse impact upon their pregnancies.
• Deficiency symptoms include growth retardation (as related to protein metabolism), delayed sexual development, mild anemia, decreased taste sensation (hypogeusia), decreased or loss of sense of smell (hyposmia or anosmia), delayed wound healing, alopecia, glossitis, angular stomatitis, and diverse forms of skin lesions (including eczema, psoriasis, acne). Night blindness, associated with an inability to mobilize retinol from the liver, may also be caused by zinc deficiency.
• Another classic condition that can develop, acrodermatitis enteropathica, an autosomal recessive disease, is characterized by zinc malabsorption which results in eczematoid skin lesions, alopecia, diarrhea, and concurrent bacterial and yeast infections. GI malabsorption can lead to deficiency. About 25% of people who have an impairment in taste and or smell are suffering from outright zinc deficiency.
• Other symptoms that may be associated with decreased zinc include hang nails, inflammation of nail cuticles, white spots on finger nails, Beau's lines (transverse lines) and poor nail growth; sleep and behavioral disturbances; psychiatric illness; all types of inflammatory bowel disease; impaired glucose tolerance; dandruff; arthritis; and alcoholism.
known or potential therapeutic uses: Acne, anorexia nervosa, anosmia (lack of taste sensation), athletic performance, benign prostatic hyperplasia, cataracts, celiac disease, cervical dysplasia, cold sores (topical), common cold, Crohn’s disease, diarrhea, Down’s syndrome, ear infections (recurrent), gastritis, HIV support, hypoglycemia, hypothyroidism, immune enhancement, infection, lead and cadmium toxicity, macular degeneration, male infertility, minor injuries, night blindness, peptic ulcer, pharyngitis (sore throat), rheumatoid arthritis, sickle cell anemia, Wilson’s disease, wound healing (oral and topical).
maintenance dose: 15-30 mg per day.
therapeutic dose: 30-350 mg per day.
• Due to potential toxicity higher doses should only be taken for the treatment of specific conditions, under the supervision of a physician or other healthcare professional trained in nutritional therapies.
• For the alleviation of the symptoms of the common cold, lozenges providing 15-25 mg of zinc in the form of zinc gluconate can be used frequently.
• Research has shown that supplementing low-income pregnant women and pregnant teenagers with 25-30 mg per day can improves pregnancy outcomes.
side effects:
• High doses of zinc, in the area of 300 mg per day, may impair immune function.
• Watch for copper deficiency if supplementing zinc for extended period of time.
• Long term zinc supplementation above 50 mg per day has shown to decrease HDL cholesterol and increase total cholesterol. This may be due to an induced copper deficiency. In addition copper deficiency anemia can occur as well. Zinc should always be taken with copper in a 10 to 1 through 30 to 1 zinc to copper ratio.
• Large doses of zinc may also promote folate deficiency.
toxicity:
• Signs and symptoms of toxicity include diarrhea, nausea and vomiting.
• Zinc at doses of 20 mg and above often causes stomach upset and/or nausea. Thus, it should always be taken with food.
contraindications: None known to date.
i think this just adds a little
http://clinical.caregroup.org/altmed/interactions/Nutrients/Zinc.htm
Zinc
Common Names: Zinc acetate, Zinc aspartate, Zinc citrate, Zinc gluconate, Zinc glycerate, Zinc oxide, Zinc picolinate, Zinc sulfate
Clinical Name: Zinc
Summary
Zinc
chemical name: Zn
forms: Zinc acetate, Zinc citrate, Zinc glycerate, Zinc picolinate, Zinc sulfate.
overview of interactions:
• nutrient affected by drug: Captopril
• nutrient affecting drug performance: Ciprofloxacin
• nutrient affected by drug: Corticosteroids, including Prednisone
• nutrient affected by drug: Oral Contraceptives
• nutrient affected by drug: Penicillamine
• nutrient affected by drug: Ranitidine (Zantac®)
• nutrient affecting drug performance: Tetracyclines
• nutrient affected by drug: Valproic Acid
• nutrient affecting drug performance: Warfarin
metabolism:
• Actively transported, zinc is regulated, in part, by sulfur containing amino acids.
• Zinc absorption is enhanced by soy protein, red wine, glucose, and lactose.
• Zinc absorption is inhibited by iron, copper, and phytates.
• Zinc is stored in muscle, spleen, bone marrow and liver. Both red blood cells and white blood cells contain high concentrations of zinc. Other tissues with high zinc concentrations are the skin, prostate, and retina (especially the macula).
function:
• Zinc is involved in the synthesis of cholesterol, protein, and fats. In addition, it regulates the release of vitamin A from the liver.
• Zinc affects cell growth, especially the epithelial tissue.
• Prostate reproductive health require zinc. Zinc inhibits the activity of 5-alpha-reductase, the enzyme that irreversibly converts testosterone to dihydrotestosterone, a form of testosterone that binds most strongly to prostate tissue causing hypertrophy.
• Zinc is required for vision.
• Zinc is also needed as:
an antioxidant cofactor for SOD;
a cofactor for alcohol metabolism;
a cofactor for delta 6 desaturase --> PGE1 synthesis.
• Insulin function requires zinc.
• The immune system uses zinc.
• Zinc is crucial for taste perception.
• Zinc provides protection against heavy metal toxicity, such as cadmium and lead, as well as copper toxicity as in Wilsons Disease.
dietary sources: Oysters, herring, sunflower and squash seeds, hard cheese, poultry, peanuts, meats, eggs, wheatgerm, soy meal, hard wheat berries, wheat bran, buckwheat, rice bran, millet, whole wheat flour, oatmeal, brown rice, cornmeal, black-eyed peas, green beans, chickpeas, lima beans, spinach, green onion, green leafy vegetables, sprouted grains.
Note: Food processing removes a large proportion of zinc as well as other trace elements.
deficiency:
• Zinc deficiencies tend to occur in alcoholics and individuals with chronic kidney disease, malabsorption problems, and sickle cell anemia. Researchers have found that low-income pregnant women and pregnant teenagers at greater risk for marginal zinc deficiencies and consequent adverse impact upon their pregnancies.
• Deficiency symptoms include growth retardation (as related to protein metabolism), delayed sexual development, mild anemia, decreased taste sensation (hypogeusia), decreased or loss of sense of smell (hyposmia or anosmia), delayed wound healing, alopecia, glossitis, angular stomatitis, and diverse forms of skin lesions (including eczema, psoriasis, acne). Night blindness, associated with an inability to mobilize retinol from the liver, may also be caused by zinc deficiency.
• Another classic condition that can develop, acrodermatitis enteropathica, an autosomal recessive disease, is characterized by zinc malabsorption which results in eczematoid skin lesions, alopecia, diarrhea, and concurrent bacterial and yeast infections. GI malabsorption can lead to deficiency. About 25% of people who have an impairment in taste and or smell are suffering from outright zinc deficiency.
• Other symptoms that may be associated with decreased zinc include hang nails, inflammation of nail cuticles, white spots on finger nails, Beau's lines (transverse lines) and poor nail growth; sleep and behavioral disturbances; psychiatric illness; all types of inflammatory bowel disease; impaired glucose tolerance; dandruff; arthritis; and alcoholism.
known or potential therapeutic uses: Acne, anorexia nervosa, anosmia (lack of taste sensation), athletic performance, benign prostatic hyperplasia, cataracts, celiac disease, cervical dysplasia, cold sores (topical), common cold, Crohn’s disease, diarrhea, Down’s syndrome, ear infections (recurrent), gastritis, HIV support, hypoglycemia, hypothyroidism, immune enhancement, infection, lead and cadmium toxicity, macular degeneration, male infertility, minor injuries, night blindness, peptic ulcer, pharyngitis (sore throat), rheumatoid arthritis, sickle cell anemia, Wilson’s disease, wound healing (oral and topical).
maintenance dose: 15-30 mg per day.
therapeutic dose: 30-350 mg per day.
• Due to potential toxicity higher doses should only be taken for the treatment of specific conditions, under the supervision of a physician or other healthcare professional trained in nutritional therapies.
• For the alleviation of the symptoms of the common cold, lozenges providing 15-25 mg of zinc in the form of zinc gluconate can be used frequently.
• Research has shown that supplementing low-income pregnant women and pregnant teenagers with 25-30 mg per day can improves pregnancy outcomes.
side effects:
• High doses of zinc, in the area of 300 mg per day, may impair immune function.
• Watch for copper deficiency if supplementing zinc for extended period of time.
• Long term zinc supplementation above 50 mg per day has shown to decrease HDL cholesterol and increase total cholesterol. This may be due to an induced copper deficiency. In addition copper deficiency anemia can occur as well. Zinc should always be taken with copper in a 10 to 1 through 30 to 1 zinc to copper ratio.
• Large doses of zinc may also promote folate deficiency.
toxicity:
• Signs and symptoms of toxicity include diarrhea, nausea and vomiting.
• Zinc at doses of 20 mg and above often causes stomach upset and/or nausea. Thus, it should always be taken with food.
contraindications: None known to date.
