Milk thistle dosage?

[ninety1stangconv]

I weigh 180 5'11" on t400 1ml a week and 50mg prop eod. I am gonna throw winni in soon. What dosage of milk thistle should I take every day? thanks

 

[Baywatch69]

1g ED is the norm dose, however, myself i wouldnt bother

 

[ninety1stangconv]

Wouldn't bother because the low dose of gear? You don't think it will cause too much damage to the ol liver.

 

[Ulter]

You should use Tyler Liver Detox with the winny. You can get it from the AF Store.

 

[yoop33]

I don't think you can take too much of a good thing. I was taking about 2 caps a day. Now I forgot how much was in those caps but it is pretty organic so it won't cause any harm taking too much.

 

[narshh]

I weigh 180 5'11" on t400 1ml a week and 50mg prop eod. I am gonna throw winni in soon. What dosage of milk thistle should I take every day? thanks

What dosage do you think?


Milk Thistle
Milk thistle for the treatment of liver disease: a systematic review and meta-analysis.

Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA.

Department of Medicine, University of California, San Francisco 94143, USA. [email protected]

PURPOSE: Milk thistle, an herbal compound, is the dietary supplement taken most frequently by patients with chronic liver disease. We performed a systematic review of the literature to determine the efficacy and safety of this herb for the treatment of liver disease. METHODS: We searched English and non-English reports through July 1999 using thirteen databases and reference lists, and contacting manufacturers and technical experts. Reviewers independently screened all reports to identify randomized placebo-controlled trials that evaluated milk thistle for the treatment of liver disease. Outcomes of primary interest included mortality, histological findings on liver biopsy specimens, serum aminotransferase and albumin levels, and prothrombin times. RESULTS: Fourteen trials met inclusion criteria. Four trials reported outcomes for mortality among 433 participants. The overall summary odds ratio for mortality in the milk thistle group compared with placebo was 0.8 (95% confidence interval [CI]: 0.5 to 1.5; P = 0.6). Three trials assessed histology on liver biopsy; study quality was inversely associated with the likelihood of histological benefit for milk thistle compared with placebo. There were no differences in serum alanine aminotransferase, aspartate aminotransferase, or albumin levels, or prothrombin times, among participants assigned to milk thistle compared with those assigned to placebo. The only statistically significant difference was a greater reduction in alanine aminotransferase levels among patients with chronic liver disease assigned to milk thistle (-9 IU/L, 95% CI: -18 to -1 IU/L; P = 0.05), but this reduction was of negligible clinical importance and no longer statistically significant after limiting analyses to studies of longer duration or of higher quality. The frequency of adverse effects was low and, in clinical trials, indistinguishable from placebo. CONCLUSION: Treatment with milk thistle appears to be safe and well tolerated. We found no reduction in mortality, in improvements in histology at liver biopsy, or in biochemical markers of liver function among patients with chronic liver disease. Data are too limited to exclude a substantial benefit or harm of milk thistle on mortality, and also to support recommending this herbal compound for the treatment of liver disease.

 

[ninety1stangconv]

thanks ulter and yoop for the useful info.

 

[Workout King]

milk thistle has more studies showing its useless than studies showing its useful... don't know where they are, but search here and you can find them. Tylers, liv52, ALA are all good tho.

 

[Big_Joe]

What dosage do you think?


Milk Thistle
Milk thistle for the treatment of liver disease: a systematic review and meta-analysis.

Jacobs BP, Dennehy C, Ramirez G, Sapp J, Lawrence VA.

Department of Medicine, University of California, San Francisco 94143, USA. [email protected]

PURPOSE: Milk thistle, an herbal compound, is the dietary supplement taken most frequently by patients with chronic liver disease. We performed a systematic review of the literature to determine the efficacy and safety of this herb for the treatment of liver disease. METHODS: We searched English and non-English reports through July 1999 using thirteen databases and reference lists, and contacting manufacturers and technical experts. Reviewers independently screened all reports to identify randomized placebo-controlled trials that evaluated milk thistle for the treatment of liver disease. Outcomes of primary interest included mortality, histological findings on liver biopsy specimens, serum aminotransferase and albumin levels, and prothrombin times. RESULTS: Fourteen trials met inclusion criteria. Four trials reported outcomes for mortality among 433 participants. The overall summary odds ratio for mortality in the milk thistle group compared with placebo was 0.8 (95% confidence interval [CI]: 0.5 to 1.5; P = 0.6). Three trials assessed histology on liver biopsy; study quality was inversely associated with the likelihood of histological benefit for milk thistle compared with placebo. There were no differences in serum alanine aminotransferase, aspartate aminotransferase, or albumin levels, or prothrombin times, among participants assigned to milk thistle compared with those assigned to placebo. The only statistically significant difference was a greater reduction in alanine aminotransferase levels among patients with chronic liver disease assigned to milk thistle (-9 IU/L, 95% CI: -18 to -1 IU/L; P = 0.05), but this reduction was of negligible clinical importance and no longer statistically significant after limiting analyses to studies of longer duration or of higher quality. The frequency of adverse effects was low and, in clinical trials, indistinguishable from placebo. CONCLUSION: Treatment with milk thistle appears to be safe and well tolerated. We found no reduction in mortality, in improvements in histology at liver biopsy, or in biochemical markers of liver function among patients with chronic liver disease. Data are too limited to exclude a substantial benefit or harm of milk thistle on mortality, and also to support recommending this herbal compound for the treatment of liver disease.

This is a bullshit study. Notice that the "reviewers" are unnamed and that they picked the studies that they thought would give them the results they wanted to get. Do you think there is bias against herbs in medicine??? Who do you think funds much of the research in medicine?? People that have a vested interest in limiting treatment to patentable products. Herbs are not patentable.

Isn't it interesting that dosage was not one of the criteria that they picked. Most of the time that you have herbal studies done by people that normally study pharmaceutical product the dosage is the same or similar to drugs. Such a 100mg or 200mg and of course
the outcome of the study is that the herb doesn't do anything. Well of course it didn't do anything the dosage needs to be a gram or two.

Here are some studies that show that Silymarin is effective in treating liver disease:
Liver protection from chronic alcoholic liver disease

A double-blind controlled study

treatment of cirrhosis

Inhibition of prostate cancer cells

treatment of colon cancer

All of these studies shows that Silymarin has a significant effect in the treatment of disease, most commonly liver disease.

Medicine today is in a disturbing phase. The problem is characterized by the ethics policy of "The New England Journal of Medicine." Their ethics policy used to state that if an author of an article had a financial stake in what was discussed in the article that needed to be stated in the article. A consumer group complained that they were not following their own ethics statement. "The New England Journal of Medicine" agreed and promised to fix the problem. They did, they changed their ethics statement!