milk thistile blocks androgen receptor (article)

[goku_kakarot77]

Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP -- Zhu et al. 22 (9): 1399 -- Carcinogenesis

^^^^

KKKKKK

peace

 

[dabuffguy]

So, it helps cancer, but compromises AR's?

In this world, we need AR's, not inhibit them.

Interesting read

 

[goku_kakarot77]

good read worth karma right?

 

[Cardinal Slin]

good read worth karma right?

lol

 

[needtogetaas]

Thats why I use premross oil.

 

[FunFun]

So, it helps cancer, but compromises AR's?

In this world, we need AR's, not inhibit them.

Interesting read

In the abstract I came across this statement:

"However, expression and steroid-binding ability of total AR were not affected by SM in western blotting and ligand-binding assays. Intriguingly, we found that nuclear AR levels are significantly reduced by SM and SB in the presence of androgens using western blotting assay and immunocytochemical staining..."

Could anyone translate this into plain English?

Where does it leave us milk thistle consumers?

 

[pip88]

I was wanting to take milk thistle during my pct with clomid and nola etc... do you think it would lessin the effects of the drugs nolva and clomid?

 

[LoneTree]

In the abstract I came across this statement:

"However, expression and steroid-binding ability of total AR were not affected by SM in western blotting and ligand-binding assays. Intriguingly, we found that nuclear AR levels are significantly reduced by SM and SB in the presence of androgens using western blotting assay and immunocytochemical staining..."

Could anyone translate this into plain English?

Where does it leave us milk thistle consumers?

This article may not be relevant at all.

Prostate cells are different from muscle cells. The major effect of testosterone in prostate is through formation of DHT by 5-alpha reductase. In muscle, it works directly and not through conversion to DHT.

Basic science articles are not meant to be directly used in clinical care. They provide facts, and in addition, may help to add a piece to puzzle.

If you read 'discussion' in the full article, there is an explanation. But simply stated, these lines do not change the over all conclusion.