Metformin?

[PlateheadJim]

Ok, who's played with it? I used it on a cutting cycle and didn't notice any difference - but I haven't used it since I read a negative report in T-mag that it drops T levels.

Well, that appears to be T-mag talking out of their ass as the only info I can find regarding that is it can lower T levels in women via ovary interaction. In males it actually can re-sensitize the HPTA (go figure) and as a result up T levels!

So, back to my question - anybody use it and notice it being worth bothering with? I would imagine it is better than ALA since afterall ALA is useful but still just a crude "supplement"

 

[Cornellius]

It makes you feel like shit......very tired fro some reason.
Also makes you shit some interesting things.
Makes you feel bloated all day, hides hunger at all.

Besides all this, it works.......if you can handle it.....I couldn´t.

 

[PlateheadJim]

YEP

Indeed it does make you feel like shit - one of the reasons I haven't jumped out of my seat to use it. When on protein shakes where almost impossible to drink and I would feel weak and tired in the AM. Although.... There are some other diabetic meds out there that my be worth playing with..

 

[nandi12]

Well, that appears to be T-mag talking out of their ass as the only info I can find regarding that is it can lower T levels in women via ovary interaction

Saudi Med J 2002 Aug;23(8):934-7 Related Articles, Links


Effects of short term metformin administration on androgens in normal men.

Shegem NS, Nasir AM, Jbour AK, Batieha AM, El-Khateeb MS, Ajlouni KM.

National Center for Diabetes Endocrinology and Genetics, Jordan University Hospital, Amman, Jordan.

OBJECTIVE: To study the effect of metformin on androgens in normal men. METHODS: A total of 12 healthy males volunteered to participate in the study. A blood sample was obtained from each of them and analyzed for the following: Testosterone (total and free), sex hormone binding globulin dehydroepiandrosterone sulphate, 17-hydroxyprogesterone, luteinizing hormone, and follicle stimulating hormone. In addition, each participant was subjected to a glucose tolerance test and his insulin level was measured. Metformin 850 mg twice daily for 2-weeks was given to each subject after which the above tests were repeated. A paired t-test was used to assess the statistical significance of any observed differences before and after metformin. RESULTS: After metformin administration, there was a significant reduction in serum level of total testosterone (p=0.0001), free testosterone (P=0.002), and 17 hydroxyprogesterone (p=0.0001). There was also a significant increase in serum level of sex hormone binding globulin (p=0.009) and dehydroepiandrosterone sulphate (P=0.0008). Serum levels of luteinizing hormone and follicle stimulating hormone showed no significant changes. Similarly, there were no changes in fasting plasma glucose, fasting serum insulin, weight, or blood pressure. CONCLUSION: Metformin administration was associated with a reduction in total testosterone, free testosterone, and 17-hydroxyprogesterone and an increase in sex hormone binding globulin and dehydroepiandrosterone sulphate in normal males. The clinical significance of these findings needs further investigation.

 

[macrophage69alpha]

metformin is not effective for non diabetics, its not all that great for them.

btw- had not seen that study nandi.. interesting..

 

[RdStrcklnd]

It tore up my insides, no good IMO.

 

[Mischief]

I like it, take about 1500-2000 /day, taken in 425 or 500 doses after the larger carb meals. If it's a HUGE meal, and I take 1000 or so, I feel all bloated, but it passes. If your taking GH it's a must. If your taking insulin, you should only be using it once or twice a week tops. On the non-insulin days, metaformin keeps the receptors sensitive.

Everyone I know who doesn't get nauseated and grotesque shits likes it (seems like 50/50 can handle it), it's much better than ALA, although it works differently. Probably why a lot of people here don't like it. I actually use both everyday, just less ALA than if I didn't.

 

[PlateheadJim]

nandi12 nice post! Indeed the effects appear to be significant on T levels. I may still consider it during a bulking cycle when "on" since natural T is shutdown anyway. However I am looking into other insulin modifiers besides R-ALA/METFORMIN, etc. Been looking at some more advanced diabetic meds but need more time before I have enough info to justify trying them.

 

[DrJMW]

I like it for a size/strength cycle. Take one 850mg tab twice daily and that's all you need. It works for folks that have obesity tendencies (insulin resistance, chronic overweight). Suppose you are 20% bodyfat now and you want to lower your bodyfat below 10 and gain muscle mass. First step is to lose the fat--HGH, captopril, low carb diet, and lots of low intensity cardio with weight training. Do this for as long as it takes to achieve the 10% BF. Then, you switch to Testo, Aromasin, and Glucophage to gain quality muscle with little fat/water gain.

For people with low BF% to begin with, Glucophage is useless, for they do not suffer from insulin resistance. These are your mesomorphs and endomorphs. It is for fat people who become lean and need to overcome their lousy genetics. Captopril is used by these same people--to overcome lousy genetics.

 

[PlateheadJim]

Hmmmm

I like it for a size/strength cycle. Take one 850mg tab twice daily and that's all you need. It works for folks that have obesity tendencies (insulin resistance, chronic overweight). Suppose you are 20% bodyfat now and you want to lower your bodyfat below 10 and gain muscle mass. First step is to lose the fat--HGH, captopril, low carb diet, and lots of low intensity cardio with weight training. Do this for as long as it takes to achieve the 10% BF. Then, you switch to Testo, Aromasin, and Glucophage to gain quality muscle with little fat/water gain.

For people with low BF% to begin with, Glucophage is useless, for they do not suffer from insulin resistance. These are your mesomorphs and endomorphs. It is for fat people who become lean and need to overcome their lousy genetics. Captopril is used by these same people--to overcome lousy genetics.

I average 6-8% and have good insulin sensitivity ... So diabetic meds may just be a waste afterall... It's just that: I LIKE TO PLAY WITH DRUGS!!!!

 

[DrJMW]

Re: Hmmmm

I average 6-8% and have good insulin sensitivity ... So diabetic meds may just be a waste afterall... It's just that: I LIKE TO PLAY WITH DRUGS!!!!

For you, it is a waste.

 

[Q8TY]

this drug keep me weak , i don't like it