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milo hobgoblin
New member
I found something I think will help clear up a few things about different esters of test and different steroids in general.
I see many posts regarding various esters of test and the common misperception that the only real difference is the half life. This is far from the case and while differing esters of test are not so dramatically different than say.. comparing stanzolol to test cypionate (which Im sure most here know have very different effects in terms and androgenic/anabolic efficacy) .. there difinitely IS a difference between them in terms of how they affect the pituitary axis and bind to the receptors in the muscle cells, primary and secondary sexual organs and tissues.
Steroids are based upon the androstane ring structure (with few exotic exceptions) that base structure having a very specific 3 dimensional shape.
Its a base 4 ring structure.. with the rings lettered from left to rigth A through D.
Rings A & B are primary responsible for the differing anabolic/androgenic response of various steroids.. and there are two factors involved.. any gropus attached to the various carbons AND the overall the dimensional shape.
Here is the key.. Modifcations on ANY ring will affect the overall shape.. so a few extra carbons up on C-17 (ring d) will affect the structure of ring A .. changing the anabolic/androgenic properties of each drug.
Here is a link to the Human Metabolom Database.. many steroids are listed. Select one and look at the 3 deminsional structure of the drugs you may have previously though were very similar and you'll realize just how differently your body actually sees them.
When you click the "view 3d structure" you can open different ones in different tabs of yuor browser and twist and turn them
Try to align the structures and look at them simultaneously and you'll see what I mean about changes to the D-ring.. even slight ones modifying the overall structure.
HMDB: Search Results
I know some of you with biochem backgrounds may find flaws in my arguements.. or logic.. if so please elaborate if so, its been a few years (LOL about 15 since I worked in steroid chem) so Im sure I may have explained things poorly but Im trying to use laymans terms and sometimes it just doesnt come out right... Im sure there are a ton of things Ive forgotten but I hope this clears a few things up for you all.
I see many posts regarding various esters of test and the common misperception that the only real difference is the half life. This is far from the case and while differing esters of test are not so dramatically different than say.. comparing stanzolol to test cypionate (which Im sure most here know have very different effects in terms and androgenic/anabolic efficacy) .. there difinitely IS a difference between them in terms of how they affect the pituitary axis and bind to the receptors in the muscle cells, primary and secondary sexual organs and tissues.
Steroids are based upon the androstane ring structure (with few exotic exceptions) that base structure having a very specific 3 dimensional shape.
Its a base 4 ring structure.. with the rings lettered from left to rigth A through D.
Rings A & B are primary responsible for the differing anabolic/androgenic response of various steroids.. and there are two factors involved.. any gropus attached to the various carbons AND the overall the dimensional shape.
Here is the key.. Modifcations on ANY ring will affect the overall shape.. so a few extra carbons up on C-17 (ring d) will affect the structure of ring A .. changing the anabolic/androgenic properties of each drug.
Here is a link to the Human Metabolom Database.. many steroids are listed. Select one and look at the 3 deminsional structure of the drugs you may have previously though were very similar and you'll realize just how differently your body actually sees them.
When you click the "view 3d structure" you can open different ones in different tabs of yuor browser and twist and turn them
Try to align the structures and look at them simultaneously and you'll see what I mean about changes to the D-ring.. even slight ones modifying the overall structure.
HMDB: Search Results
I know some of you with biochem backgrounds may find flaws in my arguements.. or logic.. if so please elaborate if so, its been a few years (LOL about 15 since I worked in steroid chem) so Im sure I may have explained things poorly but Im trying to use laymans terms and sometimes it just doesnt come out right... Im sure there are a ton of things Ive forgotten but I hope this clears a few things up for you all.
