The only problem as I see it with this supp. is that 1-AD and 4-AD don't have the same oral bioavailabilty. Basically that means that if you are taking 100mg of each you are not going to be getting the same effects of each because 4-AD is broken down alot more and rendered not as affective when taken orally. Typically you'd need to take a higher dose of 4-AD for it to be effective (higher than you would of 1-AD).