lower prolactin

[TxLonghorn]

TxLonghorn do you have any proof that b6 lowers levels??

Thanks
E

http://healthandfitnesstalk.com/forum/showthread.php?s=&threadid=29334

I was reading about this back in january and since then several posters have tried with success the b6 for gyno symptoms from taking deca and fina.

Pretty amazing, imo. Some have complained that taking that much of one b vitamin must be bad for you, like the alternative of growing tits is better, or taking bromo for extended periods would be safer. As of yet, the only thing I've read about as far as sides would be tingling in your fingers and toes that will stop when ceasing the b6 since it's water soluble.

For somebody like me, this is a godsend.

 

[sigmund]

Prolactin info:

Prolactin is a single-chain protein hormone closely related to growth hormone. It is secreted by so-called lactotrophs in the anterior pituitary. It is also synthesized and secreted by a broad range of other cells in the body, most prominently various immune cells, the brain and the decidua of the pregnant uterus.

Prolactin is synthesized as a prohormone. Following cleavage of the signal peptide, the length of the mature hormone is between 194 and 199 amino acids, depending on species. Hormone structure is stabilized by three intramolecular disulfide bonds.

Physiologic Effects of Prolactin

The conventional view of prolactin is that its major target organ is the mammary gland, and stimulating mammary gland development and milk production pretty well define its functions. Such a picture is true as far as goes, but it fails to convey an accurate depiction of this multifunctional hormone.
It is difficult to point to a tissue that does not express prolactin receptors, and although the anterior pituitary is the major source of prolactin, the hormone is synthesized and secreted in many other tissues. Overall, several hundred different actions have been reported for prolactin in various species. Some of its major effects are summarized here.

Mammary Gland Development, Milk Production and Reproduction

In the 1920's it was found that extracts of the pituitary gland, when injected into virgin rabbits, induced milk production. Subsequent research demonstrated that prolactin has two major roles in milk production:

Prolactin induces lobuloalveolar growth of the mammary gland. Alveoli are the clusters of cells in the mammary gland that actually secrete milk.

Prolactin stimulates lactogenesis or milk production after giving birth. Prolactin, along with cortisol and insulin, act together to stimulate transcription of the genes that encode milk proteins.

Prolactin also appears important in several non-lactational aspects of reproduction. In some species (rodents, dogs), prolactin is necessary for maintainance of corpora lutea (ovarian structures that secrete progesterone, the "hormone of pregnancy"). Mice that are homozygous for an inactivated prolactin gene and thus incapable of secreting prolactin are infertile due to defects in ovulation, fertilization, preimplantation development and implantation.

Effects on Immune Function

The prolactin receptor is widely expressed by immune cells, and some types of lymphocytes synthesize and secrete prolactin. These observations suggest that prolactin may act as an autocrine or paracrine modulator of immune activity. Interestingly, mice with homozygous deletions of the prolactin gene fail to show significant abnormalities in immune responses.

A considerable amount of research is in progress to delineate the role of prolactin in normal and pathologic immune responses. It appears that prolactin has a modulatory role in several aspects of immune function, but is not strictly required for these responses.

Control of Prolactin Secretion

In contrast to what is seen with all the other pituitary hormones, the hypothalamus tonically suppresses prolactin secretion from the pituitary. In other words, there is usually a hypothalamic "brake" set on the lactotroph, and prolactin is secreted only when the brake is released. If the pituitary stalk is cut, prolactin secretion increases, while secretion of all the other pituitary hormones fall dramatically due to loss of hypothalamic releasing hormones.

Dopamine serves as the major prolactin-inhibiting factor or brake on prolactin secretion. Dopamine is secreted into portal blood by hypothalamic neurons, binds to receptors on lactotrophs, and inhibits both the synthesis and secretion of prolactin. Agents and drugs that interfere with dopamine secretion or receptor binding lead to enhanced secretion of prolactin.

In addition to tonic inhibition by dopamine, prolactin secretion is positively regulated by several hormones, including thyroid-releasing hormone, gonadotropin-releasing hormone and vasoactive intestinal polypeptide. Stimulation of the nipples and mammary gland, as occurs during nursing, leads to prolactin release. This effect appears to be due to a spinal reflex arc that causes release of prolactin-stimulating hormones from the hypothalamus.

Estrogens provide a well-studied positive control over prolactin synthesis and secretion. The increasing blood concentrations of estrogen during late pregnancy appear responsible for the elevated levels of prolactin that are necessary to prepare the mammary gland for lactation at the end of gestation.
Disease States

Excessive secretion of prolactin - hyperprolactinemia - is a relative common disorder in humans. This condition has numerous causes, including prolactin-secreting tumors and therapy with certain drugs.
Common manifestations of hyperprolactinemia in women include amenorrhea (lack of menstrural cycles) and galactorrhea (excessive or spontaneous secretion of milk). Men with hyperprolactinemia typically show hypogonadism, with decreased sex drive, decreased sperm production and impotence. Such men also often show breast enlargement (gynecomastia), but very rarely produce milk.

http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/hypopit/prolactin.html

Effects of pyridoxine hydrochloride (vitamin B6) on chlorpromazine-induced serum prolactin rise in male rats.

Rosenberg JM, Lau-Cam CA, McGuire H.

To investigate if vitamin B6 inhibits prolactin release and to compare this effect to that of bromocriptine, a known suppressor of prolactin release, a study was conducted in male rats. Animals were pretreated with pyridoxine hydrochloride, pyridoxal hydrochloride, saline, or bromocriptine 30 min prior to receiving varying doses of chlorpromazine hydrochloride. Blood samples were obtained 90 min later and analyzed for serum prolactin by a double-antibody radioimmunoassay.

Another study involved pyridoxal hydrochloride and saline pretreatments 30 min prior to doses of chlorpromazine hydrochloride. Blood samples collected 60 min later were also analyzed for serum prolactin.

Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01). Pyridoxal hydrochloride, another natural form of vitamin B6, failed to suppress prolactin under the conditions of both studies. This investigation may lend support to the concept that pyridoxine hydrochloride partially inhibits prolactin by a mechanism not involving dopamine.

PMID: 501547 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=501547&dopt=Abstract

 

[sigmund]

… and here’s more info on Bromocriptine. I can’t find anything particularly bad about lowering prolactin levels in males, but I suppose it would be foolish to assume there are no downsides / side effects.

(Any Doc's / specialists out there able to elaborate on the negatives?)

Bromocriptine (Parlodel) is a well-established prescription drug used in the treatment of parkinsonism and to decrease prolactine level (raised by certain brain tumors). Though not FDA-approved for the purpose, bromocriptine also enhances sexual functions, especially the intensity of orgasms.

Bromocriptine is a well-established drug for two conditions, increased levels of the hormone prolactine and parkinsonism. The best-known brand name is Parlodel. Bromocriptine also has a sexuality enhancing effect, though it is not commonly sold for that purpose. Nevertheless, there is little doubt that in many people, bromocriptine will increase sexual response. The reason why the drug is not specifically sold as impotence or frigidity medication: a sufficient number of studies to achieve FDA approval for the specific purpose of sexual enhancement have not been conducted.

In view of the enormous marketing success of Pfizer's Viagra, many pharmaceutical companies may be tempted to distribute substances that could be proven to enhance sexual response.

The sexually enhancing effect of bromocriptine is very different from the effect of Viagra (generic name: sildenafil citrate). Viagra works primarily on the sexual organ, providing chemically for better rigidity, or some rigidity in the first place. Bromocriptine, on the other hand, primarily works on the brain, making a person more receptive for sexual stimulation and creating a frame of mind for more powerful orgasms. Both effects are a logical consequence of the way, bromocriptine is traditionally used… to lower levels of the hormone prolactin, and to increase levels of the neurotransmitter dopamine.

High levels of prolactin are generally associated with a decreased sex drive. So, by lowering levels of prolactine, especially when they are high, bromocriptine is regularly credited with increasing the interest in sex.

A similar effect is achieved by bromocriptine through the neurological route. Bromocriptine is used as a medication in parkinsonism because it will cause higher levels of the neurotransmitter dopamine. Parkinsonism is a disease caused by dopamine levels that are too low. Low dopamine levels normally also cause a loss of interest in sex, and an increased sex drive is a commonly known "side effect" of parkinsonism medications. (One person's side effect is another person's cure.)

Even amino acids that are used by the body in the production of the neurotransmitter dopamine, such as tyrosine and phenylalanine, are credited with causing an increased interest in sex, though the effects may not be as dramatic as those of sildenafil citrate (Viagra).

While the increase in sex drive caused by bromocriptine may be hard to measure, the effect on orgasms is more obvious. A considerable number of people who have tried bromocriptine have reported that orgasms become more powerful ironically because they are better controlled. There may be several almost-orgasms before the real orgasm happens, and the real orgasm may be accompanied by a histamine reaction which is more clearly felt (stuffed nose).

Obviously, we do not endorse this. However, even in countries where prescription drugs are indeed only sold on prescriptions, it is within a physician's discretion to prescribe a drug for conditions for which it has not originally been approved.

For a substance to be approved as a medication, an illness has first to be defined for which it is a cure. Nowadays, there are many newly defined illnesses, such as clinical depression, attention deficit disorder, erectile dysfunction … conditions which have previously not been considered illnesses but just part of the individuality of a particular human being.

Some members of the species are smarter than others, and some are happier, and some of the males are more virile than their neighbors. But new illnesses are constantly defined, primarily when the pharmaceutical industry has on hand a medication to overcome the condition. So, if there will soon be a medical condition named Weak Orgasm Syndrome, or Clinical Sex Drive Loss , bromocriptine is a sure medication candidate.

Disclaimer: the above text is just intended as general information, not as medical advice; for medical advice, please ask your health care provider.

http://www.medicaldictionary.net/bromocriptine.htm

 

[TxLonghorn]

Bromo is some nasty stuff. I tried it when I didn't know of any other alternatives like b6, but man, what a shitty drug.

 

[sigmund]

Bromo is some nasty stuff. I tried it when I didn't know of any other alternatives like b6, but man, what a shitty drug.

What sort of sides did you experience?

Have you (or any other bro's) tried Dostinex, are the sides as bad?

 

[TxLonghorn]

What sort of sides did you experience?

Have you (or any other bro's) tried Dostinex, are the sides as bad?

Nausea and extreme fatigue lasting hours. I was just about a worthless pos on bromo. You have to very gradually up the dose, but imo, it's not worth it unless you have no alternative. I now have an alternative.

 

[nadr7891]

can you get dostinex or bromo without a script? what are these perscribed for?

dostinex is a brand name. the active ingredient is cabergoline. it's prescribed as dostinex in .5mg tabs to lower prolactin elevated for a variety of reasons, the most common being pituitary tumor. cabergoline is also sold in 1mg, 2mg and 4mg tabs under the brand name Cabaser. it's far less expensive because it's prescribed for Parkinson's and made overseas (or maybe in Canada, by the same company who makes Dostinex by the way). Cabaser is the better, cheaper way to go and not hard to find on the Internet. the pills are easily split and i've used it on several occassions; the shit does work. for me it has absolutely NO side effects, and from what i hear bromo does.

as far as getting prolactin too low, couldn't help you there. one thing's for sure, though, if you let your prolactin get too low you'll never be able to produce quality breast milk.

Nadr