Liver toxicity of Nolva

[triggernigha]

is it tight that nolvadex is toxic to the liver at doses of upto 40mg/day?

if so what should be taken with this to combat the toxicity?

it will be used primarily for PCT after test enanthate but no orals.

thanks for any help

(cycle not started - just preping)

 

[Mac173]

40mg of nolvadex for a couple wks is not going to be all that toxic to your liver, at least not enough to worry about.

It's less toxic than oral AAS.

Take a liver support if you're worried about it.

liv-52
milk thistle
tylers liver detox

 

[Primordial Performance]

is it tight that nolvadex is toxic to the liver at doses of upto 40mg/day?

if so what should be taken with this to combat the toxicity?

it will be used primarily for PCT after test enanthate but no orals.

thanks for any help

(cycle not started - just preping)

Nolva is toxic to the liver, and is worse than most 17aa orals IMO. Its toxicity is greatly underestimated. Much of the hepatocellular carcinomas from nolva use don’t show up until years after using it.

If your worried about liver stress, raloxifene would be a better choice, but would also be much more expensive. Then again, if you run hCG during your cycle you will hardly need a PCT.

-Pp

 

[Mac173]

Nolva is toxic to the liver, and is worse than most 17aa orals IMO. Its toxicity is greatly underestimated. Much of the hepatocellular carcinomas from nolva use don’t show up until years after using it.

If your worried about liver stress, raloxifene would be a better choice, but would also be much more expensive. Then again, if you run hCG during your cycle you will hardly need a PCT.

-Pp

In your opinion or is there alterior reasons that you would make a statement like that?

 

[Primordial Performance]

In your opinion or is there alterior reasons that you would make a statement like that?

That is my educated opinion and one of the reasons I dont use this drug anymore. I wrote an extensive write up about it -

http://www.mesomorphosis.com/articles/potratz/pct-protocols.htm

-Pp

 

[lartinos]

i remember reading a study that showed nolva was not liver toxic. If I can find it i'll post it up, but it was from a year or two ago.

 

[lartinos]

This study showed it was toxic, but there was another source I had that contradicted it.

: Annu Rev Pharmacol Toxicol. 2005;45:177-202. Links
The role of metabolic activation in drug-induced hepatotoxicity.Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP.
Department of Pharmacology and Therapeutics, University of Liverpool, Sherrington Buildings, Liverpool, Merseyside L69 3GE, United Kingdom. [email protected]

The importance of reactive metabolites in the pathogenesis of drug-induced toxicity has been a focus of research interest since pioneering investigations in the 1950s revealed the link between toxic metabolites and chemical carcinogenesis. There is now a great deal of evidence that shows that reactive metabolites are formed from drugs known to cause hepatotoxicity, but how these toxic species initiate and propagate tissue damage is still poorly understood. This review summarizes the evidence for reactive metabolite formation from hepatotoxic drugs, such as acetaminophen, tamoxifen, diclofenac, and troglitazone, and the current hypotheses of how this leads to liver injury. Several hepatic proteins can be modified by reactive metabolites, but this in general equates poorly with the extent of toxicity. Much more important may be the identification of the critical proteins modified by these toxic species and how this alters their function. It is also important to note that the toxicity of reactive metabolites may be mediated by noncovalent binding mechanisms, which may also have profound effects on normal liver physiology. Technological developments in the wake of the genomic revolution now provide unprecedented power to characterize and quantify covalent modification of individual target proteins and their functional consequences; such information should dramatically improve our understanding of drug-induced hepatotoxic reactions.
__________________

 

[Primordial Performance]

Nolvadex is an established hepatotoxin— no doubt about it.

The creation of toremifene, raloxifene, and now bazedoxifene, arzoxifene, and lasofoxifene should tell you something about nolvadex and its flaws. Each new SERM is progressively becoming less toxic to the liver and bodily organs. If nolvadex was so safe, it wouldn’t be getting pushed out the back door of the clinical setting.

-Pp

 

[needtogetaas]

Nolvadex is an established hepatotoxin— no doubt about it.

The creation of toremifene, raloxifene, and now bazedoxifene, arzoxifene, and lasofoxifene should tell you something about nolvadex and its flaws. Each new SERM is progressively becoming less toxic to the liver and bodily organs. If nolvadex was so safe, it wouldn’t be getting pushed out the back door of the clinical setting.

-Pp

i would just use dermacrin sustain for pct any way..dont have to worry about any toxins that way.

 

[Muscle Overkill]

I have read to use nolva while on juice because it increases good cholesterol so I don't see why people would advise using it if it is liver toxic ?

 

[jagerbombme]

I have read to use nolva while on juice because it increases good cholesterol so I don't see why people would advise using it if it is liver toxic ?

never heard that. what about clomid?

 

[r1]

I was on Nolva @ 20mg ED for TRT for a year. I got taken off of it due to elevated liver enzymes and low HDL (good cholesterol). We're not sure if the Nolva caused both, but neither problem existed before going on it.

R1

 

[Primordial Performance]

never heard that. what about clomid?

Nolva wont protect your HDL during a cycle, especially if your using 17aa orals. As long as your over 200mg/week total AAS your lipids will be fuc*ed no matter what you use for cholesterol health.

Using nolva/clomid for the positive effects on the lipid profile is just is not worth it. Way too many side effects to even consider it.

-Pp

 

[Muscle Overkill]

Even with stuff like vytorin ?

 

[Primordial Performance]

I dont see a statin improving the HDL/LDL ratio while on AAS.

-Pp

 

[triggernigha]

Thanks for all the help guys

PP - that was a very interesting read on P C T man, it has made me reconsider the use of Nolva, and i feel alot more research will need doing. I looked up the sustain and am interested.

My proposed cycle would be a straight 250mg enanthate per week for 12 weeks (i am not competing, just doing it for personal satisfaction) and wonder the P C T you would recommend - using HcG throughout the cycle makes sence to me, as you stated in your article, but i was wondering if arimidex would be useful on such a small cycle or would it suppress too much estrogen - and the suitable doses?? or what else do you suggest to keep bloats etc in check instead of clomid/nolva??

 

[Primordial Performance]

Thanks for all the help guys

PP - that was a very interesting read on P C T man, it has made me reconsider the use of Nolvaldex - tamoxifen citrate - , and i feel alot more research will need doing. I looked up the sustain and am interested.

My proposed cycle would be a straight 250mg enanthate per week for 12 weeks (i am not competing, just doing it for personal satisfaction) and wonder the P C T you would recommend - using HCG - human chorionic gonadotropin - throughout the cycle makes sence to me, anabolic steroids you stated in your article, but i was wondering if arimidex would be useful on such a small cycle or would it suppress too much estrogen - and the suitable doses?? or what else do you suggest to keep bloats etc in check instead of clomid/Nolvaldex - tamoxifen citrate - ??

Just use the hCG at 200iu EOD. No need to run nolva after the cycle, as you wont really need it.

You shouldnt need the arimidex either, unless your sensitive to gyno and bloat. If you were going to use it, I wouldnt go any higher than .25mg day.

-Pp



-Pp