List of supplements that supposedly lower your SHBG levels!!

[SofaGeorge]

i take two 10mg valiums a day....GH release and SHBG lowering. wonderful if true! BTW, i take every drug and supplement known to man if no one noticed yet.

We respect that. You aren't a junkie. You're a pioneer.

 

[WARBIRDWS6]

We respect that. You aren't a junkie. You're a pioneer.

oddly enough thats how i look at it. very sick society here indeed. at least i don't drink alchohol or smoke (weed or cigs) or do X or any shit like that. just everything else.

 

[FreakMonster]

 

[SofaGeorge]

oddly enough thats how i look at it. very sick society here indeed. at least i don't drink alchohol or smoke (weed or cigs) or do X or any shit like that. just everything else.

Naw... before I retired I worked in the supp industry. I launched a ton of innovative substances to the health market. (Mostly because I worked with the very few companies that would actually take a chance on something new.) My first step in "finding" a new substance was always self experimentation. You've got to try it, see what it does, try to figure out how much to take, etc...

I launched melatonin, spent three years playing with it before anyone knew what it was. I can still remember when we didn't have a clue how much to take... and I was getting it from the lag in 100mg capsules. (Normal dose today is 3mg.) We lived up in the mountains, me my girlfriend and another girl. At night we'd pop between 300-1000mg... then get the ricochet effect - four hours later we were wide awake at 2:00am and could not get back to sleep... so we'd get up at night and go on moonlight hikes with the dogs.

I am probably the only person in the world who associates melatonin with moonlight hikes.

After we played with it for a while, and got the dose down, we even got to sleep through the night.

The experimentation phase with an effective supplement is the most fun part of the whole thing.

 

[WARBIRDWS6]

Naw... before I retired I worked in the supp industry. I launched a ton of innovative substances to the health market. (Mostly because I worked with the very few companies that would actually take a chance on something new.) My first step in "finding" a new substance was always self experimentation. You've got to try it, see what it does, try to figure out how much to take, etc...

I launched melatonin, spent three years playing with it before anyone knew what it was. I can still remember when we didn't have a clue how much to take... and I was getting it from the lag in 100mg capsules. (Normal dose today is 3mg.) We lived up in the mountains, me my girlfriend and another girl. At night we'd pop between 300-1000mg... then get the ricochet effect - four hours later we were wide awake at 2:00am and could not get back to sleep... so we'd get up at night and go on moonlight hikes with the dogs.

I am probably the only person in the world who associates melatonin with moonlight hikes.

After we played with it for a while, and got the dose down, we even got to sleep through the night.

The experimentation phase with an effective supplement is the most fun part of the whole thing.

lol. yeah, i worked for GNC for 10 years now....and was into supps for like 5-6 years previous. my friends used to call me "duchaine" because i was the guinea pig for everything and anything new that came out. i'd take it. BTW: melatonin gives me the wide awake effect at any dose. but kava kava and xanax....nighty night!

 

[Jguns]

The only PROVEN drug in lowering SHBG is Mesterolone i.e. Proviron.

You are forgetting about DHT, and Winstrol. To be clear, Proviron works to bind to shbg, Stanozolol reduces shbg.

Sex hormone-binding globulin response to the anabolic steroid stanozolol: evidence for its suitability as a biological androgen sensitivity test.

Sinnecker G, Kohler S.

Department of Pediatrics, University of Hamburg, West Germany.

Both the androgen-induced decline in serum sex hormone-binding globulin (SHBG) levels during puberty and the anabolic effect of exogenous testosterone are absent in patients with androgen insensitivity (testicular feminization). To determine whether the androgen-induced decline in serum SHBG could be used as a test of androgen sensitivity, we studied the effect of the anabolic-androgenic steroid stanozolol (17 beta-hydroxy-17 alpha-methyl-5 alpha-androstano-[3,2-c]pyrazol) on serum SHBG in 25 control subjects, 3 patients with complete androgen insensitivity, and 4 patients with partial androgen insensitivity. Stanozolol was administered orally for 3 days (0.2 mg/kg.day); blood samples were taken before and 5, 6, 7, and 8 days after the beginning of the test for measurements of serum SHBG. The lowest value (i.e. the peak response) in each subject was used as the measure of the response to stanozolol. In the control subjects the mean nadir serum SHBG level was 51.6 +/- 5.9% (+/- SD) of the initial value (P less than 0.001). In the 4 patients with partial androgen insensitivity the nadir serum SHBG ranged from 73-89%, and in the 3 patients with complete androgen insensitivity it ranged from 93-97% of the initial value. Thus, the decrease in serum SHBG after short term administration of stanozolol reflects androgen responsiveness and, thus, may be used to differentiate patients with androgen insensitivity syndromes from those with other causes of male pseudohermaphroditism.

However, just because SHBG is lowered does NOT mean an increase in free testosterone.

This particular study noted a reduction in total testosterone due to mesterolone administration, but no change in free testosterone levels.

The authors concluded that:

"The reduction in total plasma testosterone and the unchanged free testosterone is probably due to reduced testosterone binding to SHBG."

So even though mesterolone competes with test for SHBG binding, the diplaced test is cleared from the system faster, resulting in no net change of free test, since as the authors point out:

"the MCR [metabolic clearance rate] is inversely related to the degree of protein binding."

(1) Acta Endocrinol (Copenh) 1974 Oct;77(2):380-6

The effect of mesterolone administration to normal men on the pituitary-testicular function.

Aakvaag A, Stromme SB.

 

[jboldman]

My reading of the studies suggests that aerobic conditioning does indeed lead to an increase in gh release and in older individuals igf-1 levels and aerobic capacity are positively correlated. Since igf-1 downregulates the synthesis the shbg, it sounds to me like aerobic conditioning is exactly what we need as we get older to promote good health, lower levels of shbg and increased release of growth hormone. As far as I can determine , the only time that igf-1 is diminished by aerobic conditioning is when it is combined with caloric restriction. I can post the studies if anyone is interested.

jb

Silient: Good post. But even with that evidence it becomes a "chicken and the egg" scenario. If lower IGF-1 is what raises SHBG as we age...why does our IGF-! get lower?

Bottom Line: We get older. It does give further validy for the need for resistance exercise and the dismissal of aerobic exercise since resistance increases GH release and aerobics can lower IGF-!.

Anxiety raises SHBG. Does this mean that benzos lower it? Hmmmm.

plornive: Yes, Nolvadex, which is similar to Clomid , will raise SHBG. (Could be due to supposed lowered IGF as a matter of fact) Studies show this to be true but so does a more accurate barometer -- my dick. Nolva is another libido killer which decreases semenal volume. Nolvadex blows as bad as CLomid. The option is pretty simple. Just use less of what causes the problems that Nolva fixes.

 

[geoboy]

Nelson your right about nettle I use to use it to keep my hair.

What about Maca? I love this herb.

does the nettles use (what dose & brand btw?) impair libido??