In my opinion I don't think you will drop by taking it with prozac or other kind of an upper, but I could be wrong, but I know of some people who are on anti-depressants who take G every saturday night and they don't suffer any side effects or ill effects. I think it's more dangereous when combined with downers such as valium, xanax, alcohol etc. I don't think it's much of a risk with taking it with uppers. Whenever I take G I always take it with 10 to 12 mg's of yohimbe. I find yohimbe intensifies the effects of G especially when it comes to raising libido. But Those are only my experiences. G is something you have to experience on your own because effects varries tremendously from each individuel. I know some people who take 1 ml and get a big buzz effect and I know some who need at least 5 ml's and more for a small buzz of the exact same quality G.