When used in low to moderate doses it really doesn't affect test levels at all so ancillaries are not needed, and even though it is a 17 alpha alkylated roid (which is suppose to stress the liver) Ive read that liver damage is extemely rare even though in some tests enzymes were elevated damage to the liver didn't occur and of course the levels went back to normal. It is possible for it to lower both hdl and ldl cholestrol levels. but the ratio of the good and bad levels in most studies moved in the more favorable direction. I like them a lot so far they work really fast!!!