what do the alpha2 receptors do, and why do they need to be downregulated?
The drug is used to treat heart failure and blocks the conversion of angiotensine I and angiotensine II - it promotes the secretion of aldosterone by the surrenal cortex. One of the main effects of the drug being to bring down blood pressure down drastically.
The alpha-2a inhibites the release of the fat, while the betas promotes the release of the fat. The goal is down regulating the alpha while up regulating the beta. The angiotensine II is a need to the creation of new alpha 2a receptors. I know too down the tension, which is a good thing because the betas up it. And yes, also have a diuretic effect.
Fonz, anyidea about captopril ? It was first addressed by dan duchaine.