ketamine?

[ElCORAZON]

Ketamine is absolutely NOT A LOCAL anesthetic. It is a sedative-hypnotic..not a local anesthetic. Local anesthetics are drugs that work by inhibiting sodium channels therby inhibiting neurtransmission. For example lidocaine, cocaine, bupivicaine, chloroprocaine, prilocaine, mepivicaine, ropivicaine, etc. are local anesthetics. 150 mg is a large dose. Essentially that is 2mg/kg in the normal male patient. That is probably enough to cause the induction of GENERAL anesthesia..ie going to "SLEEP" for surgery. I agree 150 mg in the lay persons hands is lethal..basically without going into alot of details ED 50 is the effective dose of a drug to establish an effect in 50% of the subjects. LD 50 is the lethal dose of a drug that kills 50%. The ED/LD 50 ratio is what is important. This states that the larger the difference between the two doses, the safer the drug is. For example, if 1 mg was the ED 50 and 2 mg was the LD 50, then that drug really sucks ass.

 

[Enzo250]

Slopain and Kneepads are Totally Right...

Ketamine was made schedule III last year (i think it was Nov 99).

Everyone in the NYC club scene is currently using this stuff along with X... Its the next best thing to X and together it really gets you going. Take to much and get ready to go in a k-hole. Someone also said that it's not worth much to deal it... NO WAY.. Try getting some in NY and you will pay upto $75 per bottle. You then have to cook it or air it out to convert it to powder form. The Feeling is like a lsd trip. Also your movements became very robotic. IT'S NOT A GOOD DRUG. I'll Tried it many times but will never do it again.

 

[guards]

elcorazon:

I did pulled out the ole' canadian compendium and found that both of us are wrong. Thought you might be interrested in the info:

"Ketamine is a cataleptic anealgesic and aneasthetic. It has NO sedative or hypnotic properties distinguishing it from the barbituates" CPS

"The aneasthetic state of ketamine has been dteremined as dissociative in nature in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectly depress the thalamal neocotical systym before signifgantly obtunding the more ancient cebrral centers and pathways (reticular activiting and limbic systems). " CPS

Ketamine is rapidly absorbed in fatty tissues of the body, making very lipid soluble and easliy passing the blood-brain barrier.

Orally:
The ED50 is skewed when adminstered orally because the method of metabolization is wholly different than the methods recommended for this drug. Oral adminsteration will not induce the same effects as being administered by injection.

Intramuscularly:
The ED50 is :10mg/kilogram
maintenance dose is 10 mg/kg

IV administered:
ED50=2mg/kg


Ketamine has a larghe margin of safety, a dosage given up to ten times has been followed by prolonged and complete recovery.


Ketamine and barbituates are chemically incompatible if they are mixed in a syringe or aministered via the same fashion. The CNS depressants will prolong recovery time if used with babrituates.

Side effects:

Increased BP and puolse rate.
Conculsive seizures
nausea, although minimal
increased salivation
blurred vision


Overdose symptoms:

Respiratory depression
cardiac arrest

It is a sedative-hypnotic..not a local anesthetic. Local anesthetics are drugs that work by inhibiting sodium channels therby inhibiting neurtransmission. For example lidocaine, cocaine, bupivicaine, chloroprocaine, prilocaine, mepivicaine, ropivicaine, etc. are local anesthetics. 150 mg is a large dose. Essentially that is 2mg/kg in the normal male patient. That is probably enough to cause the induction of GENERAL anesthesia..ie going to "SLEEP" for surgery. I agree 150 mg in the lay persons hands is lethal..basically without going into alot of details ED 50 is the effective dose of a drug to establish an effect in 50% of the subjects

Hope this helps!

 

[pgerardone]

I can get you cocaine and heroin and you can sell it on your local street corner and probably make more money then selling K in the clubs.

 

[santo smith]

send it over Spunky, he he he

 

[ElCORAZON]

guards,

thanks for that info. I was essentially not trying to get into full details about pharmacokinetics and dynamics. Trying to keep it simple. Sedation-and hypnosis are a continuum of degrees of cortical suppression. Most basic anesthesia/pharmacology texts will describe this. I am very right about that. At least my medical boards in anesthesia dictate that. Notice my previous entry about about NMDA receptor activity. Those receptors lie in the regions you cited. also the more ancient brain you describe is better known as the reticular activating system that controls consciousness and sleep. I was trying to keep it simple. Thanks though..the more knowledge the better...learing is a continuous process. I hope this does not sound defensive..i suppose i did not take the time to fully explain or share my knowledge with the board. sorry. Again, it is a safe drug when given by professionals. I did not want to imply it was unsafe for clinical practice. I was trying to explain to others what the term ED 50 was. I give it IV practically every other day. My previous note also mentioned the effects when combined with other drugs(opiates, benzodiazepines, and barbituates) and I previously mentiond the dissociative properties associated with it and discribed it. I also mentioned the nightmares in a previous post. Point well taken though..I will be more complete in my future posts so as not to confuse anyone about my experience and professional expertise with this drug. Thanks for the info.

 

[bigchewy]

so if you can inject it intramuscularly what size needle would you use like a 29gauge?and where would you inject it?

 

[Frackal]

This is a fucking stupid post that has nothing to do with bodybuilding and will only bring more 'bad' to the board...delete this garbage.

 

[mor123]

Hey this is for the doctor. I have to ask. If you have access to all these drugs how do you keep from doing them. Or do you do them. No one knows you here so be honest I always wondered.

 

[Spunky]

I know it has nothing to do with bodybuilding i was just asking what it was and if anyone has used it.