is it true that caffeine mimics insulin

[OMEGA]

I have been dating this masters medical student...(hopefully girlfreind)

and she knows I train and am seriuos.

well when I told her that I wanted to lose a couple of more pounds and told her about eca's

she said that the caffeine would actually be counterproductive in burning fat...because it mimics insulin.....

people she goes to UCSF

wich is probably in the top 3 of best educational hospitals in the US hence the world

so what gives???

is caffeine counter productive to fat loss??

 

[bm2k]

This isn't really my speciality, but think about this: if caffiene actually impaired fat loss, why would every single supplement company use it in their fat loss stacks (remembering the research that goes into these products)?

 

[newlurker]

Just curious...........what does a masters medical student mean?????????

 

[OMEGA]

she is a Rn the kind that are allowed to right prescriptions, and that run nursing departents

I guess the most educated version of a nurse

make sense?

 

[newlurker]

In the Phd Nurse practioner program. I have so much repect for nurses. I prefer my NP to my physician.
I was just curious.....as I am in Medical Education........

 

[plornive]

First, caffeine mobilizes fatty-acids. This increases fat-burning.

Second, the "crash" that sometimes occurs with caffeine is possibly caused by the brain using a lot more blood-glucose than usual, making the user go somewhat hypoglycemic. There are other theories, though. I would be interested in hearing them.

 

[MS]

Caffeine is essentially 'glycogen sparing' in that it allows you to preferentially mobilize and burn more fats and less carbs. In this respect I would say that it is exactly the opposite of insulin. Caffeine IMPAIRS glucose uptake and utilization in skeletal muscle. And, not dissing your suped-up RN, but after working 13 years in a medical teaching facility, I can assure you that nutrition and biochemistry are the two most neglected fields of teaching. The last person I would go to for nutritional advice is a 'medically qualified' practicioner.

 

[georgie24]

IN THE ATKIN'S SO CALLED BOOK HE SAYS CAFFIENE SPIKE INSULIN

 

[NY Muscle]

i think this thing about caffeine raising insulin came from dr atkins, he felt caffeine was not good for his diet as it would release insulin or some stupid shit.

 

[MS]

Ah HA. Dr Atkin's! I rest my case. I would not take nutritional advice from a medically trained person unless they've also gone the distance and done post graduate study in nutrition and biochem. BTW, the ergogenic benefits of caffeine are only apparent if you don't use it chronically. If you drink coffee all the time, then the fat mobilizing/glycogen sparing effects seem to wane.

 

[MR. BMJ]

Farah S.L, et al. "Caffeine-Induced Impairment of insulin Action but not insulin Signaling in Human Skeletal Muscle is Reduced by Exercise." DIABETES . 51:583-590, 2002.

We investigated the effects of caffeine ingestion on skeletal muscle glucose uptake, glycogen synthase(GS) activity, and insulin signaling intermediates during 100-min euglycemic-hyperinsulinemic (100uU/ml) clamp. On two occasions, seven men performed 1-h one-legged knee extensor exercise at 3 hours before the clamp. Caffeine (5mg/kg) or placebo was administered in a randomized, double-blind fashion 1 hour before the clamp. During the clamp, whole-body glucose disposal was reduced (P<0.05) in caffeine (37.5 +/- 3.1umol X min-1 X kg-1) vs. placebo (54.1 +/- 2.9 umol X min-1 X kg-1). In accordance, the total area under the curve over 100 minutes (AUC 0-100min) for insulin-stimulated glucose uptake in caffeine was reduced (P< 0.05) by ~50% in rested and exercised muscle. Caffeine also reduced (P<0.05) GS activity before and during insulin infusion in both legs. Exercise increased insulin sensitivity of leg glucose uptake in both caffeine and placebo. Insulin increased insulin receptor tyrosine kinase (IRTK), insulin receptor substrate 1-associated phosphatidylinositol (PI) 3-kinase activities, and Ser473 phosphorylation of protein kinase B (PKB)/Akt significantly but similarly in rested and exercised legs. Furthermore, insulin significantly decreased glycogen synthase kinase-3alpha (GSK-3alpha) activity equally in both legs. Caffeine did not alter insulin signaling in either leg. Plasma epinephrine and muscle cAMP concentrations were increased in caffeine. We conclude that 1) Caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle: 2) Caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) Exercise reduces the detrimental effects of caffeine on insulin action in muscle.

MR. BMJ

 

[Stryc-9]

I'm with MS on this one...

We also have to consider that caffeine and ephedrine are used synergistically by most of us here at Elite - such that the total effects of the two combined are greater than the sum of each on its own.

In simpler terms - the effect of caffeine combined with ephedrine is not the same as the effect of caffeine on its own. Having said that, I don't believe that caffeine on its own mimics insulin anyway, but I digress....

 

[Par Deus]

Caffeine mobilizes fatty acids, which can decrease insulin sensitivity, which could cause a greater insulin response to a high carb meal.

But, it certainly is not counterproductive to fat loss.