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big_boy_1
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Interesting new drug to reduce bloat...
Many bodybuilders, most in fat, think that water retention is mainly caused by estrogen or progesterone.
The reality is that steroids activate aldosterone (water retention) receptors even without converting to estrogens or progestagens.
Spinorolactone is an effective aldosterone receptor antagonist, but unfortunately its also an androgen receptor antagonist, so it may cause gyno.
Eplerenone (Instra) is a much more selective aldosterone receptor antagonist, besides it increases potassium, so it would stack nicely with clen,
read:
# Mechanism
1. Selective Aldosterone Receptor Antagonist
2. More selective for aldosterone than Spironolactone
# Indication
1. Congestive Heart Failure
2. Hypertension
# Contraindications
1. Serum Potassium >5.5 mEq/L
2. Tyep II Diabetes Mellitus with Microalbuminuria
3. Renal insufficiency
1. Serum Creatinine >2.0 in men or >1.8 mg/dl in women
2. Creatinine Clearance <50 ml/min
# Adverse Effects
1. Hyperkalemia
2. Hypertriglyceridemia
3. Hyponatremia
4. Dizziness
5. Fatigue
6. Diarrhea
7. Cough
8. Less Gynecomastia and Impotence than Spironolactone
# Drug Interactions
1. Potassium supplements
2. Potassium sparing Diuretics
3. Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
4. ACE Inhibitors
# References
1. (2003) Lexi-Comp Drug Database
2. (2003) Med Lett Drugs Ther 45(1156):39-40
3. Stier (2003) Heart Dis 5(2):102-18
love karma
Many bodybuilders, most in fat, think that water retention is mainly caused by estrogen or progesterone.
The reality is that steroids activate aldosterone (water retention) receptors even without converting to estrogens or progestagens.
Spinorolactone is an effective aldosterone receptor antagonist, but unfortunately its also an androgen receptor antagonist, so it may cause gyno.
Eplerenone (Instra) is a much more selective aldosterone receptor antagonist, besides it increases potassium, so it would stack nicely with clen,
read:
# Mechanism
1. Selective Aldosterone Receptor Antagonist
2. More selective for aldosterone than Spironolactone
# Indication
1. Congestive Heart Failure
2. Hypertension
# Contraindications
1. Serum Potassium >5.5 mEq/L
2. Tyep II Diabetes Mellitus with Microalbuminuria
3. Renal insufficiency
1. Serum Creatinine >2.0 in men or >1.8 mg/dl in women
2. Creatinine Clearance <50 ml/min
# Adverse Effects
1. Hyperkalemia
2. Hypertriglyceridemia
3. Hyponatremia
4. Dizziness
5. Fatigue
6. Diarrhea
7. Cough
8. Less Gynecomastia and Impotence than Spironolactone
# Drug Interactions
1. Potassium supplements
2. Potassium sparing Diuretics
3. Cytochrome P450 3A4 inhibitors (e.g. Ketoconazole)
4. ACE Inhibitors
# References
1. (2003) Lexi-Comp Drug Database
2. (2003) Med Lett Drugs Ther 45(1156):39-40
3. Stier (2003) Heart Dis 5(2):102-18
love karma
