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MrMakaveli
New member
Belive it was a topic of interest of some on this board a month or two ago. Ran across this while searching for various things...
Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase.
Tian WX, Li LC, Wu XD, Chen CC.
Department of Biology, the Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China. [email protected]
Fatty acid synthase (EC 2. 3. 1. 85, abbr. FAS) is reported as a potential new therapeutic target for the treatment of obesity. Thirty one Chinese medicinal herbs used in weight reducing prescriptions of Traditional Chinese Medicine (TCM) were investigated for FAS inhibition. It was found that 17 of these herbs exhibited FAS inhibitor activity, and 9 were highly potent FAS inhibitors. The inhibitory potencies of the active components of tuber fleeceflower root, parasitic loranthus, green tea leaf and ginkgo leaf were similar to or greater than cerulenin and C75. The first three of these four herbs significantly reduced body weight of rats upon their oral incubation. Moreover, tuber fleeceflower root and parasitic loranthus significantly reduced food intake in rats. These results indicate that many of weight reducing herbs used in TCM do so by inhibiting FAS. They also hold promise for the development of new nontoxic and low cost weight reducing substances from these herbs.
PMID: 14998716 [PubMed - indexed for MEDLINE]
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We arent rats so C75 research in rats isnt expectd to hold but if green tea is close or equal to C75 in inhibition, this drug may not be as great as it seems from some other studies. Just info for anyone interested.
Though on the other hand, I read ECG is responsible for FAS inhibition and NOT ECGC so are there any green tea extracts with known amounts of the former?
Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase.
Tian WX, Li LC, Wu XD, Chen CC.
Department of Biology, the Graduate School of Chinese Academy of Sciences, Beijing 100039, PR China. [email protected]
Fatty acid synthase (EC 2. 3. 1. 85, abbr. FAS) is reported as a potential new therapeutic target for the treatment of obesity. Thirty one Chinese medicinal herbs used in weight reducing prescriptions of Traditional Chinese Medicine (TCM) were investigated for FAS inhibition. It was found that 17 of these herbs exhibited FAS inhibitor activity, and 9 were highly potent FAS inhibitors. The inhibitory potencies of the active components of tuber fleeceflower root, parasitic loranthus, green tea leaf and ginkgo leaf were similar to or greater than cerulenin and C75. The first three of these four herbs significantly reduced body weight of rats upon their oral incubation. Moreover, tuber fleeceflower root and parasitic loranthus significantly reduced food intake in rats. These results indicate that many of weight reducing herbs used in TCM do so by inhibiting FAS. They also hold promise for the development of new nontoxic and low cost weight reducing substances from these herbs.
PMID: 14998716 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
We arent rats so C75 research in rats isnt expectd to hold but if green tea is close or equal to C75 in inhibition, this drug may not be as great as it seems from some other studies. Just info for anyone interested.
Though on the other hand, I read ECG is responsible for FAS inhibition and NOT ECGC so are there any green tea extracts with known amounts of the former?
