Interesting abstract showing winstrol/progesterone receptor interaction....

[HUCKLEBERRY FINNaplex]

Hi fellas...Was reading through some of my abstracts and found this interesting one,showing a definite stanozolol/Progesterone receptor interaction,thought you guys might enjoy it as well...

Ellis AJ, Cawston TE, Mackie EJ.

Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK.

The anabolic steroid stanozolol stimulates the production of prostaglandin E2 (PGE2) and the matrix metalloproteinases collagenase and stromelysin in human skin fibroblasts but not in rheumatoid synovial fibroblasts. The basis for these differential responses was investigated at the levels of DNA synthesis and steroid receptor binding. Stanozolol inhibited fibroblast growth factor (FGF)-stimulated DNA synthesis in both the skin and synovial fibroblasts, showing that both cell types were capable of responding to the compound. Competitive binding assays indicated that stanozolol bound specifically to both the skin and synovial fibroblasts. Binding of stanozolol to both cell types could be partially displaced by progesterone, indicating that stanozolol binds to the progesterone receptor. Immunocytochemical studies confirmed the presence of progesterone receptors on skin and synovial fibroblasts. However, progesterone failed to elicit any response with respect to collagenase production in either cell type. Nortestosterone, dexamethasone and 17 beta-oestradiol had no effect on binding of stanozolol to either cell type. These results indicate that the inhibition of DNA synthesis by stanozolol is elicited through the progesterone receptor. The effects of stanozolol on collagenase and PGE2 production are mediated by a different receptor, present on skin but not synovial fibroblasts, and as yet unidentified.

 

[ultragainz]

thats a "ultrapost" and needs a "ultrabump" great post bro..... doesn't get any better then this!

 

[conan69]

Ok that is interesting but what i get from it is that, it causes a conversion to progesterone with i thought everyone knew


i dont know...some of this stuff is so complicated

i just like sticking stuff in my ass to see the results
you can read all you want i will use real life trial and error


so if you come to any conclusions before me. let me know


thanks

btw...Good job

 

[ultragainz]

"ultrabump"

 

[ORGANON CANON]

 

[HUCKLEBERRY FINNaplex]

[email protected] represent the hardcore my man,and there's no shame in that.You walk the walk,where few others dare to go,hehheh...

 

[Ulter]

Hey Huck can I get you to post that where Fukkenshredded can get a look at it. I don't want to steal a great post by you. Just to see what he says. He was telling E2 the other day about paths that winny takes that other AS don't and I wonder if this is what he was talking about.

 

[Big Johnson]

GREAT POST, HUCK. CONFIRMS WHAT WE ALWAYS SUSPECTED: WINNY IS AN ANTI-P, MUCH LIKE NOLVA IS AN ANTI-E.

 

[Ulter]

Thank you my friend.

 

[HUCKLEBERRY FINNaplex]

Anytime,good buddy...

 

[MUSTANG_18]

Great post Huck!

M18

 

[Hugh Gellatts]

When RU-486 becomes available it will be a hard decision between using that or winny (when I use massive amounts of tren). I recently read that RU-486 is not totally harmless in regard to the liver. I wonder which one is the least "toxic?"

 

[HUCKLEBERRY FINNaplex]

Good question.Maybe Fonz will want to chime in,since he's used both products and probably has the bloodwork to confirm his particular reactions to each...

 

[The Iron Game]

Bump for this post.

Although personally I dont believe winstrol is in any way effective for problems arising due to use of deca, fina, anadrol. It may eliminate a certain % of progesterone from binding to the pr, but there IMHO is no fixed law saying that because winny is being used that progesterone arising, say from deca, will not attach to the pr and exert any negative effects. In the case of anadrol binding directly to the pr rather than aromatising and working its neative effects in this way, I believe it is the same as with deca. Winny may have a better binding affinity but the fact that other hormones / steroids may also get to bind to the pr should not be ruled out. If in doubt use another steroid. Eq in case of deca, dbol in case of anadrol (yes I know), winny instead of fina (yes I know again). Although dbol and winny may not be as effective as anadrol and fina, safety before gains, especially where you can successfully eliminate serious sides for sure over speculation.

Comments

 

[Fonz]

Really no comparison

The difference in anti-progesterone activity
between stanozolol and Mifepristone
is VAST.
In my experience its like comparing
Arimidex and Clomid in terms
of anti-estrogenic activity.
Winstrol may/may not work while
RU-486 ALWAYS WORKS.

With RU however you can run into some
problems while with stanozolol they are
pretty rare.

RU has some impact on blood lipid
profiles, decreases cortisol too much
at high doses leading to joint pain
etc..etc..

Bottom line: Don't rely too much on the winny
for anti-p reasons. It works, but not that well.
RU should be available to more BB'ers in the
next 3-4 months or so I have been told.
Just too much demand.

Godspeed

Godspeed

 

[Bubba]

BUMP!!!

 

[HUCKLEBERRY FINNaplex]

One last shameless bump before it slips off into archive never-never-ville....

 

[NYStrip]

<File>--<Save As> for sure. Thanks.

 

[Big Johnson]

Bump

 

[Big Johnson]

anotha bump

 

[MR. BMJ]

Yep, this one is going up too. Very good article by our good friend Huck.

MR. BMJ

 

[Realgains]

good info from Huck!

 

[Texas Ranger]

Huck, how do you all of this stuff??? LOL!

 

[Realgains]

Cause he is HUCK.......he he he UP!!!

 

[nandi12]

Hi fellas...Was reading through some of my abstracts and found this interesting one,showing a definite stanozolol/Progesterone receptor interaction,thought you guys might enjoy it as well...

Virtually all androgens bind to the progesterone receptor to some degree; similarly progestins (and antiprogestins) bind to the androgen receptor. RU 486 binds to the androgen receptor as an antiandrogen, rendering it useless for bodybuilders.

As far as the winstrol article goes, has anyone bothered to actually read the whole study? Presumably we are supposed to believe winstrol has some kind of antiprogestin cabability because it blocked FGF stimulated DNA synthesis.

The effect on DNA synthesis was measured by thymidine uptake. Less thymidine uptake means less DNA synthesis. Quoting from page 38 of the article,

" A significant inhibition of thymidine uptake was seen in response to stanozolol in both cell types. The steroids nortestosterone, oxymetholone, and progesterone itself were also tested for their effect on thymidine uptake to determine whether the effects of stanozolol on DNA synthesis were unique. These other compounds also inhibited DNA synthesis in both cell types"

In other words, winstrol has THE SAME effect as progesterone on progesterone receptor mediated DNA synthesis: they both block it. So rather than acting as an antiprogesterone in this study, winstrol, as well as nandrolone and oxymetholone, act in the same manner as progesterone.

 

[TommyGunns]

bumpity bump.