Insulin

[Tatyana]

Insulin deals with more than glucose, it is a hormone of nutrient storage,which includes ALL the nutrients including fat and amino acids.

Insulin is an ANABOLIC hormone that stimulates the biosynthetic pathways, with the key tissues being adipose (fat), the liver and MUSCLE.

It promotes glucose uptake into muscle to replenish the largest store of glycogen in the body (and muscle glycogen stays in the muscle, this includes heart muscle, and increases the uptake of amino acids into muscle, which are used to make protein, which is the basic building block of muscle.

Insulin is released in a pulsatile fashion, every 11-15 minutes with a half life of 2-6 minutes NO MATTER WHAT YOU EAT.

Fasting levels of insulin are about 20-100 pmol/l
Postprandial (feeding) ae 350-580 pmol/l

Insulin release is not only triggered by hyperglycaemia (high levels of glucose in the blood), but by certain amino acids and the gut hormones VIP, GIP and CCK.

Insulin also triggers other anabolic hormones to be released.

Insulin promotes CELL GROWTH.


Insulin resistance is usually a disorder of the elderly or obese. It basically means there is too much body for the amount of insulin produced.

Insulin resistance is the pre-syndrome to full blown type II diabetes.

A drop in weight of 10-15% usually corrects this.

Insulin resistance can also occur as a result of the combination of simple carbohydrates and saturated fat. The membranes of all the cells of the body are lipid (fat) membranes, and the membranes, in particular those of muscle, reflect the fatty acids in the diet.

Saturated fat and high GI simple carbs cause the membranes to become 'stiff' so that the receptors for insulin and glucose receptors are no longer able to move through the double layer of phospholipids (google fluid mosaic model if you want more info on cellular membranes).

Insulin triggers transporters to be taken from the inside of the cell (cytoplasm) to the cell surface.

All receptors on the cell surface are very specific, they work with a 'lock and key' mechanism. It is often cell surface receptors, when triggered to be 'open' that induces a number of cancers.

Insulin receptors are a tyrosine kinase receptor, and this is one of the basic cell surfacing signalling pathways (google tyrosine kinase receptor for pictures)

There are 5 categories of glucose receptors, some are tissue specific, called GLUT 1 through to GLUT 5.

GLUT 4 is stored in the cytoplasm of the cell and is transported to the cell surface under the influence of insulin and increases the uptake of glucose by 6-10 x.

GLUT 1 and 3 are always present on the cell surface, (GLUT 1 is on RBCs or red blood cells).

GLUT 5 transports fructose into muscle cells, and does not require the action of insulin.

Triggering of insulin release post workout is simple with a post-workout meal or shake.

The combination of simple sugars and some amino acids (therefore a hydrolysed whey or whey isolate or BCAAs) will trigger a greater insulin response than just simple carbs on their own.

To lose body fat is not only a matter of calories by managing the insulin response. The preferred carbohydrates are high fiber, slow digesting. low GI/GL carbohydrates. Eating carbohydrates in combination with protein and fat also slows their digestion.

 

[busamuscle]

Insulin deals with more than glucose, it is a hormone of nutrient storage,which includes ALL the nutrients including fat and amino acids.

Insulin is an ANABOLIC hormone that stimulates the biosynthetic pathways, with the key tissues being adipose (fat), the liver and MUSCLE.

It promotes glucose uptake into muscle to replenish the largest store of glycogen in the body (and muscle glycogen stays in the muscle, this includes heart muscle, and increases the uptake of amino acids into muscle, which are used to make protein, which is the basic building block of muscle.

Insulin is released in a pulsatile fashion, every 11-15 minutes with a half life of 2-6 minutes NO MATTER WHAT YOU EAT.

Fasting levels of insulin are about 20-100 pmol/l
Postprandial (feeding) ae 350-580 pmol/l

Insulin release is not only triggered by hyperglycaemia (high levels of glucose in the blood), but by certain amino acids and the gut hormones VIP, GIP and CCK.

Insulin also triggers other anabolic hormones to be released.

Insulin promotes CELL GROWTH.


Insulin resistance is usually a disorder of the elderly or obese. It basically means there is too much body for the amount of insulin produced.

Insulin resistance is the pre-syndrome to full blown type II diabetes.

A drop in weight of 10-15% usually corrects this.

Insulin resistance can also occur as a result of the combination of simple carbohydrates and saturated fat. The membranes of all the cells of the body are lipid (fat) membranes, and the membranes, in particular those of muscle, reflect the fatty acids in the diet.

Saturated fat and high GI simple carbs cause the membranes to become 'stiff' so that the receptors for insulin and glucose receptors are no longer able to move through the double layer of phospholipids (google fluid mosaic model if you want more info on cellular membranes).

Insulin triggers transporters to be taken from the inside of the cell (cytoplasm) to the cell surface.

All receptors on the cell surface are very specific, they work with a 'lock and key' mechanism. It is often cell surface receptors, when triggered to be 'open' that induces a number of cancers.

Insulin receptors are a tyrosine kinase receptor, and this is one of the basic cell surfacing signalling pathways (google tyrosine kinase receptor for pictures)

There are 5 categories of glucose receptors, some are tissue specific, called GLUT 1 through to GLUT 5.

GLUT 4 is stored in the cytoplasm of the cell and is transported to the cell surface under the influence of insulin and increases the uptake of glucose by 6-10 x.

GLUT 1 and 3 are always present on the cell surface, (GLUT 1 is on RBCs or red blood cells).

GLUT 5 transports fructose into muscle cells, and does not require the action of insulin.

Triggering of insulin release post workout is simple with a post-workout meal or shake.

The combination of simple sugars and some amino acids (therefore a hydrolysed whey or whey isolate or BCAAs) will trigger a greater insulin response than just simple carbs on their own.

To lose body fat is not only a matter of calories by managing the insulin response. The preferred carbohydrates are high fiber, slow digesting. low GI/GL carbohydrates. Eating carbohydrates in combination with protein and fat also slows their digestion.

Nice! Could you do a follow-up on that wich is in red? This is some of the stuff I refrained from posting in the last insulin thread.

 

[Tatyana]

Here is a start, the effects of insulin are known to be pleiotrophic, or diverse

http://www.biochemsoctrans.org/bst/029/0525/bst0290525.htm

Before all of you go off thinking that insulin is the be all and end all thing, it is lower levels of insulin that are known to result in longevity (or living a much longer life), so taking extra insulin, or causing it to be released too often, AGE much more rapidly.

There is no wonder drug lads, everything is a double edged-sword, it is all about the balance

http://www.supercentenarian.com/archive/insulin-brain.html

http://www.sciencedaily.com/releases/2005/08/050826073745.htm

 

[jumpmaster82]

great post, ive said athousand times that insulin is the most dangerous BB drug out there. anyone whos thinking of taking it should read this thoroughly.

 

[busamuscle]

great post, ive said athousand times that insulin is the most dangerous BB drug out there. anyone whos thinking of taking it should read this thoroughly.

Yes and I think that Tat should put all of these articles into one post and sticky it for awhile!

 

[eddymerckx]

great post, ive said athousand times that insulin is the most dangerous BB drug out there. anyone whos thinking of taking it should read this thoroughly.

i cannot agree more---and the worst part is this is the title of one of ef's reports listed on the larger, public site. Even though it goes into all the risks--the title and blurb is not something that should be for public consumption:

Insulin: The Most Powerful Drug for Muscular Bodybuilding Part 1 | Part 2
Ask any of the truly massive bodybuilders which anabolic substance had the most profound effect upon their physique and the answer from the largest bodybuilders will unanimously be insulin.

 

[Tatyana]

i cannot agree more---and the worst part is this is the title of one of ef's reports listed on the larger, public site. Even though it goes into all the risks--the title and blurb is not something that should be for public consumption:

Insulin: The Most Powerful Drug for Muscular Bodybuilding Part 1 | Part 2
Ask any of the truly massive bodybuilders which anabolic substance had the most profound effect upon their physique and the answer from the largest bodybuilders will unanimously be insulin.

That may be true, but if you look at some of the current physiques, they are not as aesthetic as those before the huge use of insulin and GH.

Both of these drugs will have an effect on the mid-section of the torso.

 

[bottleneckblooz]

That may be true, but if you look at some of the current physiques, they are not as aesthetic as those before the huge use of insulin and gh - growth hormone (somatropin) - .

Both of these drugs will have an effect on the mid-section of the torso.

I agree. Today's bodybuilding physiques don't look good with the big guts. As far as I'm concerned, insulin and gh use doesn't improve physiques at all, it ruins them.

 

[eddymerckx]

That may be true, but if you look at some of the current physiques, they are not as aesthetic as those before the huge use of insulin and gh - growth hormone (somatropin) - .

Both of these drugs will have an effect on the mid-section of the torso.

i agree--i just wish that ef report was a little lower profile--

 

[LiquidPhire]

Can't imagine trying slin anytime soon or ever for that matter. Diabetes? No thanks.

 

[GUARDIAN]

have their ever been any reported insuling resistance or diabetes from any IFBB pros. Mike Matarazzo was pretty open about his use and others. He said a few would spend in upwards of $20,000 to get ready for the Arnold. Using insulin, hgh, and massive amounts other injectibles. You would think somone by now would of been hospitalized by now or developed diabetes.

 

[eddymerckx]

have their ever been any reported insuling resistance or diabetes from any IFBB pros. Mike Matarazzo was pretty open about his use and others. He said a few would spend in upwards of $20,000 to get ready for the Arnold. Using insulin, human growth hormone - somatropin - , and massive amounts other injectibles. You would think somone by now would of been hospitalized by now or developed diabetes.

check out the last paragraph

HGH implicated in bodybuilder's diabetes
Reported here in Newswise, the British Journal of Sports Medicine has published a case of a body builder suffering complications from HGH/steroid/insulin use.
The bodybuilder complained of severe chest pain, apparently from complications of diabetes. Next time it will be from his cardiac hypertrophy.

Newswise — Use of growth hormone to boost athletic performance can lead to diabetes, reports a study published ahead of print in the British Journal of Sports Medicine.

The study reports the case of a 36 year old professional body-builder who required emergency care for chest pain.

He had lost 40 kg in 12 months, during which he had also experienced excessive urination, thirst, and appetite.

He admitted to using anabolic steroids for 15 years and artificial growth hormone for the past three. He had also taken insulin, a year after starting on the growth hormone.

This was done to counter the effects of high blood sugar, but he had stopped taking it after a couple of episodes of acute low blood sugar (hypoglycaemia) while at the gym.

Tests revealed that his liver was inflamed, his kidneys were enlarged and that he had very high blood sugar. He was also dehydrated, and diagnosed with diabetes.

He was given intravenous fluids and gradually increasing amounts of insulin over five days, after which he was discharged. His symptoms completely cleared up, and he was no longer diabetic.

The use of growth hormone has steadily risen among amateur athletes and bodybuilders all round the world, say the authors, because it is easy to buy online and difficult to detect in screening tests—unlike anabolic steroids.

The authors believe that this is the first reported case of diabetes associated with the use of high dose growth hormone, and urge anyone taking high doses to regularly check their blood sugar levels.

Click here to view the paper in full:

 

[lanky]

next time i see a pro BB'er in the ICU on a insulin drip for dka,,i will say hi

generally it is the total opposite of ronnie coleman, they look like the actor from the show from the 70's where he would always say "dynomite"

 

[1tight_tl]

I remember a few years ago when i was cycling on and off constantly and a pro body builder taught me how to take insulin at extremely low levels (2-4iu's)..I read sooo much learning the proper way to take it and how dangerous it could be if abused or incorrectly used...I did put on MASSIVE amounts of size during my cycle but thank god i got my head out my ass and realized i can manipulate this just through diet and get the same effects....No insulin for me b/c i dont want to turn myself diabetic nor am I going to be a pro body builder... ..

great thread, good info